Compare and book 5 Star hotels in Santa Ana, Panama City

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Check availability on Santa Ana 5 Star Hotels

Our top choices for Santa Ana 5-star hotels

Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4641)
"Awesome great place to stay "
United States
Herbert
The price is 3.229.209 ₫
3.552.130 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Hotel Riu Plaza Panama
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1000)
"I loved everything about my stay "
United States
Stephanie
The price is 4.733.190 ₫
5.206.509 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Waldorf Astoria Panama
2 restaurants, local cuisine
W Panama

W Panama

W Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1001)
"It is a hotel with very comfortable and nicely designed rooms in the heart of Panama City. The hotel staff is efficient, attentive and friendly."
United States
SVETLANA
The price is 5.463.864 ₫
6.010.250 ₫ total
includes taxes & fees
20 Dec - 21 Dec
W Panama
4 outdoor pools, free pool cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is 7.092.669 ₫
7.801.936 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
JW Marriott Panama
Exterior
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (555)
"Great hotel and location "
United Kingdom
Russell
The price is 10.086.525 ₫
11.095.178 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Sofitel Legend Casco Viejo, Panama City
Outdoor pool
Hilton Panama

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1000)
"Great place to stay."
United States
Salvador
The price is 4.906.356 ₫
5.396.992 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton Panama
3 outdoor pools, pool umbrellas, pool loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very good, (1001)
"Our stay was very nice, the service the hotel provides is wonderful, I highly recommend it"
United States
Mayra Alexandra Montes
The price is 5.245.043 ₫
5.769.548 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The Westin Playa Bonita Panama
40-inch Smart TV with cable channels, TV
Renaissance Panama City Hotel

Renaissance Panama City Hotel

Renaissance Panama City Hotel
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (94)
"Great location and amazing staff"
United States
Aziz
The price is 3.057.412 ₫
3.363.153 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Renaissance Panama City Hotel
Couples treatment room(s), sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is 5.263.915 ₫
5.790.306 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Bristol Panama, a Registry Collection Hotel
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (637)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is 6.108.235 ₫
6.719.059 ₫ total
includes taxes & fees
12 Dec - 13 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
View from property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
5.0 star property
San Francisco
8.4 out of 10, Very good, (1000)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá
Outdoor pool
Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
5.0 star property
Bella Vista
6.2 out of 10, (1000)
"It has a nice casino and it's very conveniently located. Breakfast was very good as well. Staff very helpful and attention oriented. Good experience "
United States
Aldo
Waymore Hotel Spa and Casino
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Ana.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
The price is 2.899.270 ₫ per night from 23 Dec to 24 Dec
2.899.270 ₫
3.189.197 ₫ total
23 Dec - 24 Dec
includes taxes & fees
8.4/10 Very Good! (2,315 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Santa Ana Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Santa Ana?
Villa Palma Boutique Hotel is one of the best options around the Panama City neighbourhood of Santa Ana according to Expedia customers. Sofitel Legend Casco Viejo, Panama City and Waldorf Astoria Panama are other 5-star hotels in this area that rank highest with guests.
How much does it cost to stay in a 5-star hotel in Santa Ana?
You can find many different pricing options for 5-star hotels in Santa Ana on Expedia. How much you'll pay will depend on when you travel, length of stay and other factors. Compare all of the available properties for your preferred dates and make use of our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from 3.189.197 ₫

What makes a hotel 5 stars in Santa Ana?
From gourmet dining venues and 24/7 fitness centres to pools and the finest bedding, the 5-star experience in Santa Ana is all about luxury and comfort. But it requires more than just top-notch amenities to get a 5-star rating. Stays also have to deliver remarkable services like beauty treatments, on-site laundry and dry cleaning and room service any time night or day.

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