Antofagasta Region Holidays

Book a Hotel + Flight or Car together to unlock savings

Top destinations in Antofagasta Region

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San Pedro de Atacama

San Pedro de Atacama

Top hotels in Antofagasta Region

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460 San Pedro de Atacama Antofagasta
Fully refundableReserve now, pay when you stay
The price is 3.291.375 ₫ per night from 4 May to 5 May
3.291.375 ₫
3.291.375 ₫ total
4 May - 5 May
8.2/10 Very Good! (366 reviews)
Beautiful hotel. Beautiful pool area. Close to everything you need and within the pick up area for most tour companies.

Reviewed on 11 Apr 2026

Diego de Almagro San Pedro de Atacama
Our Habitas Atacama

Our Habitas Atacama

4 out of 5
Domingo Atienza 282 San Pedro de Atacama Antofagasta
Fully refundableReserve now, pay when you stay
The price is 7.109.370 ₫ per night from 11 May to 12 May
7.109.370 ₫
7.109.370 ₫ total
11 May - 12 May
8.6/10 Excellent! (339 reviews)
Es un buen hotel.

Reviewed on 1 Apr 2026

Our Habitas Atacama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18 San Pedro de Atacama
Fully refundableReserve now, pay when you stay
The price is 5.529.510 ₫ per night from 15 Apr to 16 Apr
5.529.510 ₫
5.529.510 ₫ total
15 Apr - 16 Apr
9.2/10 Wonderful! (402 reviews)
todo muy bien

Reviewed on 10 Apr 2026

Hotel La Casa de Don Tomas
See all 308 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Antofagasta Region holiday package cost?
From as low as . Yes, you read that right. Our Antofagasta Region packages are the best way to stretch your budget. Combine your hotels, flights and car rentals and discover this lively destination.
How do I get a cheap travel package to Antofagasta Region?
Our Antofagasta Region holiday packages promise plenty of savings for the savvy traveller. For the best deals, simply bundle your hotel, flights and activities into an affordable package. But impressive bargains are only the start of your next unforgettable adventure. Book with Expedia and you'll have more than 550 airlines and 1null000null000 properties throughout the world to pick from. Whatever your budget, there's a package that's perfect for you.
What are the top hotels in Antofagasta Region?
Have a look at ibis Antofagasta and NH Antofagasta. They're the first choice for lots of travellers to Antofagasta. If San Pedro de Atacama is on your travel itinerary, Park Hotel Calama and Noi Casa Atacama are cosy options.
How far in advance should I book my Antofagasta Region holiday?
It can be tricky to know when is the ideal time to book your trip to Antofagasta Region. But typically the earlier you book, the better the prices. Sometimes, you can reserve your flights and hotels up to a year before your departure date. If you're considering a last-minute getaway, no need to stress! There are fabulous deals featured on Expedia every single day.
What does an Expedia Antofagasta Region travel package include?
From hotels and airfares to rental cars, Expedia can help you shape an Antofagasta Region package that's perfect for you. Holidaying for a week or two? Consider a rental car, hotel and flight bundle. If you're taking a short break, a flight and hotel deal could be more your style. Activities can also be added once you've made your booking. Our holiday packages make it simple to save and plan.
What should I know before booking an Antofagasta Region travel package?
Tailor deals to suit your budget with an Expedia package. Airfares, hotels, rental cars — we're a one-stop shop for all of them. You'll save precious dollars just for bundling your bookings. Whether you're embarking on a skiing adventure or drinking cocktails on a beach, your perfect getaway is just clicks away.
Can I choose my airline with an Antofagasta Region Expedia holiday package?
Expedia has access to more than 550 airline partners worldwide, so you sure can! Simply select your preferred carrier and put together the perfect Antofagasta Region trip.
If I'm not able to travel, can I cancel my Antofagasta Region holiday package?
Whether it's your flight or hotel, you can cancel and rebook it. Locked in your Antofagasta Region holiday package in the last 24 hours? You may be able to make changes at no cost. For bookings older than that, you may be charged a fee by your hotel, airline or car rental company. For further information, visit our Customer Service Portal. We'll help you every step of the way.

Popular places to visit

Valley of the Moon

Valley of the Moon

Explore the great outdoors at Valley of the Moon, a lovely green space in San Pedro de Atacama. You can seek out the local tours in this quaint area.

Valley of the Moon
Pukara de Quitor Archaeological Site

Pukara de Quitor Archaeological Site

You can find out about the history of San Pedro de Atacama with a trip to Pukara de Quitor Archaeological Site. You can seek out the local tours in this quaint area.

Pukara de Quitor Archaeological Site
Arco Iris Valley

Arco Iris Valley

Explore the great outdoors at Arco Iris Valley, a lovely green space in San Pedro de Atacama. You can seek out the local tours while in the area.

Arco Iris Valley

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