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Check availability on Clayton Spa Hotels

Our top choices for Clayton hotels with a spa

Body treatments, aromatherapy, hot stone massages, deep-tissue massages
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is 13.152.143 ₫
15.353.550 ₫ total
includes taxes & fees
23 Dec - 24 Dec
The Ritz-Carlton, St. Louis
Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very good, (1003)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is 4.010.218 ₫
5.123.802 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Ameristar Casino Resort and Spa
Massages
21C Museum Hotel St Louis

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1490)
"Room was perfect and parking was a breeze. We really enjoyed the art was wonderful. "
United States
London
The price is 3.534.474 ₫
4.264.609 ₫ total
includes taxes & fees
18 Dec - 19 Dec
21C Museum Hotel St Louis
Couples treatment room(s), hot tub, body treatments, aromatherapy
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1001)
"The staff was amazing. The bed was so comfortable. "
United States
Mary
The price is 10.938.155 ₫
12.789.875 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Four Seasons Hotel St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Clayton?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travellers highly recommend the restaurants in Clayton. Make sure you pay a visit to the museums during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your stay.
What's there to see and do in Clayton?
Enjoy all that Clayton has to offer when you visit Chapel of St. Timothy And St. Titus, Concordia Seminary, St. Louis Union Station and Gateway Arch. If you have some spare time during your trip, you might want to check out Saint Louis Galleria Mall and St. Louis Art Museum.
What is a Clayton spa hotel?
Spa hotels in Clayton provide lodging and have an on-site spa offering services including facials and body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.