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Mississippi County
Missouri
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A bridge over a muddy river with green trees and hills in the background.

A bridge over a muddy river with green trees and hills in the background.

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Mississippi County Accommodation: Most Popular Cities to Stay

A sunset over a calm lake with tall trees reflected in the water.

A tree-lined landscape with a river and fields.

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28 Oct - 29 Oct

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29 Oct - 30 Oct

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Our top choices for Mississippi County hotels

A building with a fountain and flower beds in front.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

1. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 star property

Charleston

6.8 out of 10, (443 reviews)

6.8/10

(443 reviews)

"Everything was great clean helpful Everything friendly."

"Everything was great clean helpful Everything friendly."

United States

Kathleen

The price is 1.717.703 ₫

1.717.703 ₫

1.923.083 ₫ total

includes taxes & fees

30 Oct - 31 Oct

The Riverstone Hotel Charleston-Sikeston

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property

Charleston

6.8 out of 10, (681 reviews)

6.8/10

(681 reviews)

"Breakfast was light but good"

"Breakfast was light but good"

United States

zandra

The price is 1.537.123 ₫

1.537.123 ₫

1.721.319 ₫ total

includes taxes & fees

2 Nov - 3 Nov

Super 8 by Wyndham Charleston/Sikeston East MO

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

3. Eagle Inn Charleston

Eagle Inn Charleston

2.0 star property

Charleston

6.6 out of 10, (107 reviews)

6.6/10

(107 reviews)

"Great"

"Great"

United States

Jackson

The price is 1.704.786 ₫

1.704.786 ₫

1.908.875 ₫ total

includes taxes & fees

29 Oct - 30 Oct

Eagle Inn Charleston

A hotel lobby with a reception desk, seating area, and a large window.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property

Cairo

6.4 out of 10, (296 reviews)

6.4/10

(296 reviews)

"Good service,nice stuff and no complaints"

"Good service,nice stuff and no complaints"

United States

Santiago

The price is 1.778.671 ₫

1.778.671 ₫

1.973.969 ₫ total

includes taxes & fees

15 Nov - 16 Nov

Quality Inn Cairo I-57

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Hotels recommended for families in Mississippi County

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property

Sikeston

9.6 out of 10, Exceptional, (1,004)

9.6/10

Exceptional

(1,004)

The price is 2.429.266 ₫

2.429.266 ₫

2.793.048 ₫ total

includes taxes & fees

1 Nov - 2 Nov

Drury Inn & Suites Sikeston, MO

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property

Sikeston

9.0 out of 10, Wonderful, (649)

9.0/10

Wonderful

(649)

The price is 2.460.539 ₫

2.460.539 ₫

2.798.249 ₫ total

includes taxes & fees

22 Nov - 23 Nov

Hampton Inn Sikeston

A conference room with a long table, multiple chairs, and a television screen on the wall.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property

Sikeston

8.8 out of 10, Excellent, (519)

8.8/10

Excellent

(519)

The price is 2.507.062 ₫

2.507.062 ₫

2.851.155 ₫ total

includes taxes & fees

1 Nov - 2 Nov

Holiday Inn Express & Suites Sikeston Southwest by IHG

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3.0 star property

Sikeston

9.4 out of 10, Exceptional, (118)

9.4/10

Exceptional

(118)

The price is 2.610.446 ₫

2.610.446 ₫

2.968.730 ₫ total

includes taxes & fees

8 Nov - 9 Nov

Fairfield Inn & Suites by Marriott Sikeston

Property amenity

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3.0 star property

Sikeston

9.2 out of 10, Wonderful, (28)

9.2/10

Wonderful

(28)

The price is 2.817.214 ₫

2.817.214 ₫

3.203.876 ₫ total

includes taxes & fees

5 Nov - 6 Nov

TownePlace Suites by Marriott Sikeston

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

Room

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 star property

Sikeston

8.4 out of 10, Very good, (1,005)

8.4/10

Very good

(1,005)

The price is 2.061.994 ₫

2.061.994 ₫

2.350.157 ₫ total

includes taxes & fees

8 Nov - 9 Nov

Best Western Plus Sikeston I-55

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property

Sikeston

8.4 out of 10, Very good, (829)

8.4/10

Very good

(829)

The price is 1.796.039 ₫

1.796.039 ₫

2.047.262 ₫ total

includes taxes & fees

29 Oct - 30 Oct

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

An outdoor patio area with a blue sectional sofa, an orange ottoman, and black metal chairs.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

A corridor with a vending machine displaying various beverages and a wall with hanging products.

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 star property

Union City

9.2 out of 10, Wonderful, (445)

9.2/10

Wonderful

(445)

The price is 1.860.912 ₫

1.860.912 ₫

2.209.833 ₫ total

includes taxes & fees

22 Nov - 23 Nov

Sleep Inn at Discovery Park of America

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Top Mississippi County Hotel Reviews

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

10/10 Excellent

"has stayed he every time i come to town and have never been disappointed"

joseph 1-night trip

Posted 13 hours ago

Sleep Inn at Discovery Park of America

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

10/10 Excellent

"Ok"

Richard 2-night trip

Posted 2 days ago

Hospitality House Union City I 69 / US 51

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"Room was very clean and staff was kind and helpful"

Marcia 1-night trip

Posted 2 days ago

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"We had a nice overnight stay here. The sleeper/sofa was not comfortable, but very few are. It was a good selection of foods for the breakfast. We especially enjoyed the coffee machine that freshly grinds the coffee beans and brews it immediately. We also liked the style of the luggage carts. They were less bulky and easier to handle."

Michelle 1-night trip

Posted 3 days ago

Holiday Inn Express & Suites Sikeston Southwest by IHG

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

8/10 Good

"It was good for an overnight stay - inexpensive, in a pretty spot - we enjoyed going for a walk."

Thomas 1-night trip

Posted 4 days ago

Super 8 By Wyndham Marston

Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent

"Great hotel, clean spacious room, good breakfast choice"

Deborah 1-night trip

Posted 5 days ago

Hampton Inn Sikeston

Hampton Inn Union City

Hampton Inn Union City

10/10 Excellent

"Very clean Comfy beds Good variety of breakfast items"

Melody 1-night trip

Posted 9 days ago

Hampton Inn Union City

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