Find hotels in East Prairie, MO

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Top 10 East Prairie hotels and places to stay

Days Inn and Suites by Wyndham Sikeston

2.0 star property
Sikeston
7.2 out of 10, Good, (1004)
"A great stay in every aspect. "
United States
Gertrude
The price is 1.658.170 ₫
1.889.898 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Days Inn and Suites by Wyndham Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (427)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is 2.509.662 ₫
2.841.564 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
Sikeston
8.6 out of 10, Excellent, (439)
"Well maintained property. We’ll stop again should we need to."
United States
Janet DeJean
The price is 2.509.662 ₫
2.841.565 ₫ total
includes taxes & fees
28 Nov - 29 Nov
Holiday Inn Express & Suites Sikeston Southwest by IHG

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very good, (1004)
"Very convenient and great breakfast "
United States
Duwaine
The price is 2.083.652 ₫
2.374.842 ₫ total
includes taxes & fees
30 Nov - 1 Dec
Best Western Plus Sikeston

Sleep Inn at Discovery Park of America

2.5 star property
Union City
9.2 out of 10, Wonderful, (302)
"Awesome room wonderful breakfast great staff"
United States
Thomas
The price is 2.218.362 ₫
2.634.304 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Sleep Inn at Discovery Park of America

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very good, (710)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is 1.726.447 ₫
1.967.717 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (609)
"Staff was great! Room was nice. "
United States
Lana
The price is 1.411.685 ₫
1.566.617 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
Sikeston
6.6 out of 10, (560)
"The room was good a/c kept it cold "
United States
Mary
The price is 1.523.724 ₫
1.736.729 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Super 8 by Wyndham Sikeston/Miner Area

Pear Tree Inn Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Everything was clean, staff was friendly "
United States
Matthew
The price is 2.029.610 ₫
2.333.037 ₫ total
includes taxes & fees
30 Nov - 1 Dec
Pear Tree Inn Sikeston

Hospitality House Union City I 69 / US 51

2.5 star property
Union City
6.8 out of 10, (358)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is 1.434.356 ₫
1.703.512 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Hospitality House Union City I 69 / US 51

Comfort Inn & Suites Sikeston I-55

2.5 star property
Sikeston
8.4 out of 10, Very good, (277)
"Room was clean, breakfast was very good. "
United States
Connie
The price is 2.218.362 ₫
2.528.378 ₫ total
includes taxes & fees
27 Nov - 28 Nov
Comfort Inn & Suites Sikeston I-55

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
The price is 2.530.488 ₫
2.909.574 ₫ total
includes taxes & fees
27 Nov - 28 Nov
Drury Inn & Suites Sikeston, MO

Quality Inn Union City US 51

2.5 star property
Union City
8.4 out of 10, Very good, (482)
"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is 1.770.208 ₫
2.102.123 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Quality Inn Union City US 51

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
Sikeston
9.2 out of 10, Wonderful, (37)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is 2.662.562 ₫
3.014.686 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Fairfield Inn & Suites by Marriott Sikeston

Country Hearth Inn & Suites Union City

2.5 star property
Union City
8.6 out of 10, Excellent, (547)
"Fantastic "
United States
Michael
The price is 1.897.800 ₫
2.253.687 ₫ total
includes taxes & fees
24 Nov - 25 Nov
Country Hearth Inn & Suites Union City

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (272)
"Break fast was excellent "
United States
Uma
The price is 1.748.591 ₫
1.940.587 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Quality Inn Cairo I-57

Hampton Inn Union City

2.5 star property
Union City
9.4 out of 10, Exceptional, (160)
"Staff was very friendly, room was quiet, easy to get to. Room was clean and comfortable❤️"
United States
Diana
The price is 2.636.200 ₫
3.130.487 ₫ total
includes taxes & fees
30 Nov - 1 Dec
Hampton Inn Union City

TownePlace Suites by Marriott Sikeston

3.0 star property
Sikeston
8.8 out of 10, Excellent, (6)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is 3.189.802 ₫
3.611.653 ₫ total
includes taxes & fees
30 Nov - 1 Dec
TownePlace Suites by Marriott Sikeston

Holiday Inn Express & Suites Union City by IHG

2.5 star property
Union City
9.2 out of 10, Wonderful, (305)
"It was a great hotel! No complaints. Loved the front staff!"
United States
Felicia
The price is 2.509.662 ₫
2.980.223 ₫ total
includes taxes & fees
29 Nov - 30 Nov
Holiday Inn Express & Suites Union City by IHG

Travel Inn

2.5 star property
Marston
5.8 out of 10, (115)
"Had a great time loved it "
United States
Shyianne
Travel Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Hotels in East Prairie with star rating

Frequently asked questions

What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.