Find hotels in East Prairie, MO from 1.292.126 ₫

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Check prices for these dates

Tonight
20 Dec - 21 Dec
Tomorrow
21 Dec - 22 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1004)
"Clean room, great location and friendly staff"
United States
Mark
The price is 2.368.087 ₫
2.722.550 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Drury Inn & Suites Sikeston, MO
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1005)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is 1.833.892 ₫
2.090.180 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Best Western Plus Sikeston
Individually decorated, individually furnished, desk, blackout curtains
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (720)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is 1.460.219 ₫
1.664.285 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (548)
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is 1.894.417 ₫
2.249.670 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Country Hearth Inn & Suites Union City
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
"Staff was great! Room was nice. "
United States
Lana
The price is 1.634.161 ₫
1.813.510 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (318)
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is 1.990.730 ₫
2.363.991 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Sleep Inn at Discovery Park of America
Indoor pool, outdoor pool
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Everything was clean, staff was friendly "
United States
Matthew
The price is 1.973.362 ₫
2.268.616 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Pear Tree Inn Sikeston
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (165)
"Clean room, nice breakfast"
United States
STUART
The price is 2.697.288 ₫
3.203.030 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Union City
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (729)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Exterior
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is 2.552.555 ₫
3.031.160 ₫ total
includes taxes & fees
15 Jan - 16 Jan 2026
Holiday Inn Express & Suites Union City by IHG
Soundproofing, free WiFi, bed sheets
Travel Inn

Travel Inn

Travel Inn
2.5 star property
Marston
6.0 out of 10, (116)
"Had a great time loved it "
United States
Shyianne
The price is 1.131.211 ₫
1.292.126 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Travel Inn
Standard Room, 2 Double Beds, Non Smoking | Blackout curtains, iron/ironing board, free WiFi, bed sheets
Reelfoot Lake Inn

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (460)
"Nice and quiet but there were bugs in the room the fridge didn't keep things cold and the A/C didn't keep the room cool. Great place if you're a fisherman."
United States
Carla
The price is 1.834.682 ₫
2.105.298 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Reelfoot Lake Inn
Room, 1 King Bed, Non Smoking | View from room
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (104)
"Middle of nowhere hotel was ok"
United States
David
The price is 1.591.794 ₫
1.766.526 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Eagle Inn Charleston
Free buffet breakfast
Quality Inn Union City US 51

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (487)
"The staff I interacted with were pleasant and helpful. Initially they had me in a 2nd floor room, but accommodated my asking for a first floor due to problems I was having with my knee and back. The bed was comfortable and overall the room was nice except for the bathroom shower, it had mold growing in it. Breakfast the next morning was ok."
United States
Rose
The price is 1.767.052 ₫
2.098.374 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn Union City US 51
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
"Great hotel, great staff"
United States
Dmitry
The price is 1.517.060 ₫
1.732.862 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Super 8 By Wyndham Marston
Property amenity
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is 2.657.815 ₫
3.009.311 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Fairfield Inn & Suites by Marriott Sikeston
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
"Break fast was excellent "
United States
Uma
The price is 1.904.153 ₫
2.113.229 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Quality Inn Cairo I-57
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (448)
"Friendly staff clean rooms "
United States
Christopher
The price is 2.567.818 ₫
2.907.411 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Sikeston
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (120)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is 1.406.274 ₫
1.673.115 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Country Yard Inn and Suite
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is 2.447.295 ₫
2.770.949 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent
"Staff"
April 1-night trip
Posted 13 days ago
Fairfield Inn & Suites by Marriott Sikeston

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is 1.460.219 ₫ per night from 21 Dec to 22 Dec
1.460.219 ₫
1.664.285 ₫ total
21 Dec - 22 Dec
includes taxes & fees
8.4/10 Very Good! (719 reviews)

Hotels in East Prairie with star rating

Frequently asked questions

What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.