Find hotels in East Prairie, MO from 1.667.258 ₫

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Check prices for these dates

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10 Dec - 11 Dec
Tomorrow
11 Dec - 12 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for East Prairie hotels

1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
"A great stay in every aspect. "
United States
Gertrude
The price is 1.658.170 ₫
1.889.898 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Days Inn and Suites by Wyndham Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (442)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is 2.510.424 ₫
2.842.428 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is 2.452.410 ₫
2.776.741 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express & Suites Sikeston Southwest by IHG
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1003)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is 1.882.554 ₫
2.145.642 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Sikeston
Individually decorated, individually furnished, desk, blackout curtains
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (718)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is 1.462.827 ₫
1.667.258 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (315)
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is 2.128.732 ₫
2.527.870 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Sleep Inn at Discovery Park of America
Indoor pool, outdoor pool
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Everything was clean, staff was friendly "
United States
Matthew
The price is 1.976.886 ₫
2.272.668 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Pear Tree Inn Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.6 out of 10, (561)
"ALL GREAT"
United States
NELSON
The price is 1.565.903 ₫
1.784.971 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Sikeston/Miner Area
Lobby
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (366)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is 1.434.356 ₫
1.703.512 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Hospitality House Union City I 69 / US 51
Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
The price is 2.372.316 ₫
2.727.412 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Drury Inn & Suites Sikeston, MO
Free buffet breakfast
Quality Inn Union City US 51

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (485)
"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is 1.770.208 ₫
2.102.123 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Quality Inn Union City US 51
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (281)
"Room was clean, breakfast was very good. "
United States
Connie
The price is 2.218.362 ₫
2.528.378 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Comfort Inn & Suites Sikeston I-55
Property amenity
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is 2.663.370 ₫
3.015.601 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Fairfield Inn & Suites by Marriott Sikeston
Property amenity
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is 3.111.660 ₫
3.523.177 ₫ total
includes taxes & fees
18 Dec - 19 Dec
TownePlace Suites by Marriott Sikeston
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (164)
"Clean room, nice breakfast"
United States
STUART
The price is 2.298.766 ₫
2.729.784 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hampton Inn Union City
Lobby
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (547)
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is 1.897.800 ₫
2.253.687 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Country Hearth Inn & Suites Union City
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (725)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Exterior
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (309)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is 2.688.924 ₫
3.193.096 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Holiday Inn Express & Suites Union City by IHG
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
"Break fast was excellent "
United States
Uma
The price is 1.886.774 ₫
2.093.942 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Quality Inn Cairo I-57
Soundproofing, free WiFi, bed sheets
Travel Inn

Travel Inn

Travel Inn
2.5 star property
Marston
6.0 out of 10, (116)
"Had a great time loved it "
United States
Shyianne
Travel Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent
"Staff"
April 1-night trip
Posted 3 days ago
Fairfield Inn & Suites by Marriott Sikeston

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is 1.462.827 ₫ per night from 16 Dec to 17 Dec
1.462.827 ₫
1.667.258 ₫ total
16 Dec - 17 Dec
includes taxes & fees
8.4/10 Very Good! (716 reviews)

Hotels in East Prairie with star rating

Frequently asked questions

What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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