Find hotels in East Prairie, MO from 1.666.940 ₫

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Check prices for these dates

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11 Dec - 12 Dec
Tomorrow
12 Dec - 13 Dec
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12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for East Prairie hotels

Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is 2.451.201 ₫
2.775.374 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express & Suites Sikeston Southwest by IHG
Reception
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (547)
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is 1.897.440 ₫
2.253.260 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Country Hearth Inn & Suites Union City
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (442)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is 2.509.186 ₫
2.841.027 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Sikeston
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (315)
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is 2.128.328 ₫
2.527.389 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Sleep Inn at Discovery Park of America
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Everything was clean, staff was friendly "
United States
Matthew
The price is 1.976.511 ₫
2.272.237 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Pear Tree Inn Sikeston
Handicap Room | Blackout curtains, iron/ironing board, free WiFi, bed sheets
Reelfoot Lake Inn

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (459)
"Nice and quiet but there were bugs in the room the fridge didn't keep things cold and the A/C didn't keep the room cool. Great place if you're a fisherman."
United States
Carla
The price is 1.837.610 ₫
2.108.658 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Reelfoot Lake Inn
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (726)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is 2.371.866 ₫
2.726.895 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Drury Inn & Suites Sikeston, MO
Suite, 2 Queen Beds, Non Smoking | Individually furnished, desk, laptop workspace, blackout curtains
MainStay Suites Union City, TN

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
"Perfect, staff was very helpful."
United States
Marcos
The price is 2.477.558 ₫
2.942.232 ₫ total
includes taxes & fees
15 Dec - 16 Dec
MainStay Suites Union City, TN
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1003)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is 1.881.626 ₫
2.144.584 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Sikeston
Free daily buffet breakfast
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (309)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is 2.688.414 ₫
3.192.491 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Holiday Inn Express & Suites Union City by IHG
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (118)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is 1.408.518 ₫
1.675.784 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Country Yard Inn and Suite
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (164)
"Clean room, nice breakfast"
United States
STUART
The price is 2.383.848 ₫
2.830.820 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hampton Inn Union City
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.8 out of 10, (103)
"Middle of nowhere hotel was ok"
United States
David
The price is 1.594.335 ₫
1.769.345 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Eagle Inn Charleston
Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
"Staff was great! Room was nice. "
United States
Lana
The price is 1.636.770 ₫
1.816.261 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (281)
"Room was clean, breakfast was very good. "
United States
Connie
The price is 2.217.942 ₫
2.527.900 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn & Suites Sikeston I-55
Lobby
Quality Inn Union City US 51

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (485)
"The staff I interacted with were pleasant and helpful. Initially they had me in a 2nd floor room, but accommodated my asking for a first floor due to problems I was having with my knee and back. The bed was comfortable and overall the room was nice except for the bathroom shower, it had mold growing in it. Breakfast the next morning was ok."
United States
Rose
The price is 1.769.873 ₫
2.101.724 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn Union City US 51
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (718)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is 1.462.550 ₫
1.666.940 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Desk, laptop workspace, blackout curtains, iron/ironing board
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston
2.5 star property
Charleston
6.8 out of 10, (406)
"The staff was very friendly and accommodating "
United States
Arturo
The price is 1.731.655 ₫
1.921.703 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Quality Inn Charleston - Sikeston
Exterior
Super 8 By Wyndham Marston

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
"Comfortable bed. Quiet. "
Canada
Ronald
The price is 1.519.481 ₫
1.735.626 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Super 8 By Wyndham Marston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent
"Staff"
April 1-night trip
Posted 4 days ago
Fairfield Inn & Suites by Marriott Sikeston

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is 1.462.550 ₫ per night from 14 Dec to 15 Dec
1.462.550 ₫
1.666.940 ₫ total
14 Dec - 15 Dec
includes taxes & fees
8.4/10 Very Good! (716 reviews)

Hotels in East Prairie with star rating

Frequently asked questions

What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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