Search Hotels in Downtown South San Francisco, San Francisco

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11 Dec - 12 Dec
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12 Dec - 13 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Downtown South San Francisco hotels

Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.0 out of 10, Very good, (2010)
"Breakfast is great. Staff is great."
United States
Trina
The price is 2.663.178 ₫
3.128.402 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Interior detail
Airport Inn

Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
8.8 out of 10, Excellent, (972)
"Very clean room, friendly staff and secure parking."
United States
Christopher
The price is 2.606.571 ₫
3.056.797 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Airport Inn
Fridge, microwave, coffee/tea maker, dining tables
Miller Apartments

Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.4 out of 10, Good, (15)
"Own bedroom was quiet and tidy, shared bathroom clean and tidy, good communication "
Australia
Kasey
The price is 1.579.740 ₫
3.842.388 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Miller Apartments
Lobby
Inn By The SFO

Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.8 out of 10, Good, (1000)
"Excellent property!!! I would definitely recommend!!! Great stay!!! "
United States
David
Inn By The SFO
Lobby sitting area
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (7184)
"Good location and great hotel to stay, the bed was very comfortable and the breakfast was good with lots of options! "
Canada
Veronica
The price is 3.224.154 ₫
4.879.422 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hotel Riu Plaza Fisherman's Wharf
Breakfast, lunch, dinner served; local cuisine
DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport

DoubleTree by Hilton San Francisco Airport
4.0 star property
9.3 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1357)
"Nice hotel and area "
Canada
Robert
The price is 2.569.184 ₫
2.921.034 ₫ total
includes taxes & fees
14 Dec - 15 Dec
DoubleTree by Hilton San Francisco Airport
Front of property – evening/night
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
15.4 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2116)
"Great stay "
United States
Samantha
The price is 2.461.235 ₫
2.896.751 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton San Francisco Financial District
Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
16.7 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (3826)
"We stay here a lot, great place and safe."
United States
Albert
The price is 3.056.797 ₫
4.806.199 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hotel Caza Fisherman's Wharf
American cuisine
Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront

Hilton San Francisco Airport Bayfront
4.0 star property
9.9 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2725)
"Nice airport hotel…staff was great, breakfast was amazing "
United States
Lynne
The price is 2.461.235 ₫
2.798.301 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton San Francisco Airport Bayfront
Exterior
Hotel Aluxor SFO

Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
3.8 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2562)
"Clean room, close to airport, quiet. "
Canada
Jana
Hotel Aluxor SFO
Free daily buffet breakfast
Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
16.6 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (2216)
"spotless, breakfast, location, all excellent I will come back!"
United States
Oscar
The price is 3.133.151 ₫
4.477.510 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express and Suites Fisherman's Wharf by IHG
Outdoor pool
The Marina Inn on San Francisco Bay

The Marina Inn on San Francisco Bay

The Marina Inn on San Francisco Bay
2.5 star property
20.6 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2285)
"Great place to stay!"
United States
Dixon
The Marina Inn on San Francisco Bay
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
14.7 km from Downtown South San Francisco
9.4 out of 10, Exceptional, (3059)
"Best location, friendly staff, had a wonderful time stayed! "
United States
Kalinda
The price is 1.994.157 ₫
2.356.300 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Chancellor Hotel on Union Square
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
15.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2795)
"Clean and comfortable room, good staff, great location. "
United Kingdom
David
The price is 2.640.272 ₫
3.107.468 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Club Quarters Hotel in San Francisco
Exterior
The Westin San Francisco Airport

The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2032)
"Room great, location and shuttle were excellent Enjoyed 2 restaurants and Starbucks on site. "
United States
Robert
The price is 2.709.781 ₫
3.885.457 ₫ total
includes taxes & fees
22 Dec - 23 Dec
The Westin San Francisco Airport
Exterior
King George Hotel

King George Hotel

King George Hotel
3.0 star property
14.5 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2101)
"What a wonderful stay completely recommend Daya was amazing"
United States
Glenda
The price is 2.299.385 ₫
3.101.429 ₫ total
includes taxes & fees
20 Dec - 21 Dec
King George Hotel
Lobby
Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
3.0 star property
1.8 km from Downtown South San Francisco
8.4 out of 10, Very good, (1695)
"Great place to stay "
United States
Florence
The price is 2.407.448 ₫
2.846.495 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Best Western Plus Grosvenor Airport Hotel
Premium bedding, pillow-top beds, in-room safe, desk
Hotel 1550

Hotel 1550

Hotel 1550
3.5 star property
5.1 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1040)
"Great front desk experience, nice room and very convenient to the airport. "
United States
Elmaz
The price is 2.558.349 ₫
3.031.485 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Hotel 1550
Terrace/patio
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel
3.0 star property
7.8 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (4760)
"Very pleasant experience and decent breakfast. "
Canada
michael
The price is 3.181.596 ₫
3.587.250 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Bay Landing San Francisco Airport Hotel
Lobby
Best Western Inn & Suites San Mateo - San Francisco Airport

Best Western Inn & Suites San Mateo - San Francisco Airport

Best Western Inn & Suites San Mateo - San Francisco Airport
2.5 star property
11.8 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1259)
"Staff was great and check in was perfect."
United States
FLORENCE CARMELA
The price is 2.487.827 ₫
2.859.633 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Best Western Inn & Suites San Mateo - San Francisco Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
Union Square featuring a skyscraper and a city

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

Fisherman\'s Wharf featuring a bay or harbour

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and Hyde Street Pier.

South of Market which includes skyline, a park and cbd

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to Chase Center – discover South of Market, a destination also famous for its shopping.

Nob Hill showing street scenes and a city

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.

Top Downtown South San Francisco Hotel Reviews

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Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.
How many hotels should I expect to find in the Downtown South San Francisco area?
When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 13 Expedia hotels and other accommodation options in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.
What can I see and do in this South San Francisco neighbourhood?
See's Candies, Cinemark Century at Tanforan and K1 Speed are just a few of the places to visit in and around Downtown South San Francisco. K1 Speed San Francisco and The Shops at Tanforan are also worth a visit when you're out sightseeing in South San Francisco.