Search Hotels in Illinois Medical District, Chicago

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
8 Dec - 9 Dec
Tomorrow
9 Dec - 10 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Illinois Medical District, Chicago

Exterior
Hyatt House Chicago Medical/University District

Hyatt House Chicago Medical/University District

3.5 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1234)
"Good place to stay "
United States
Matthew
The price is 2.442.532 ₫
2.867.288 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hyatt House Chicago Medical/University District
Business centre
Hampton Inn & Suites Chicago Medical District UIC

Hampton Inn & Suites Chicago Medical District UIC

2.5 star property
Illinois Medical District
9.6 out of 10, Exceptional, (356)
"Would stay there again...loved it!"
United States
Deborah
The price is 2.298.854 ₫
2.698.625 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hampton Inn & Suites Chicago Medical District UIC
Lobby
Hyatt Place Chicago Medical/University District

Hyatt Place Chicago Medical/University District

3.0 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1410)
"We definitely enjoyed our stay. Very nice clean room comfortable bed we didn’t want to get out of and excellent customer service at check in and out. Definitely recommend staying here 10/10 "
United States
Brenden
The price is 2.330.489 ₫
2.735.761 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Hyatt Place Chicago Medical/University District
Reception
Eurostars Magnificent Mile

Eurostars Magnificent Mile

4.0 star property
River North, 4.8 km from Illinois Medical District
9.0 out of 10, Wonderful, (3153)
"Amazing and will be staying again!"
United States
Angie
The price is 2.467.577 ₫
2.896.687 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Eurostars Magnificent Mile
Terrace/patio
DoubleTree by Hilton Chicago - Magnificent Mile

DoubleTree by Hilton Chicago - Magnificent Mile

4.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.8 out of 10, Excellent, (2184)
"Nice Hotel"
United States
Alan
The price is 2.356.325 ₫
2.766.089 ₫ total
includes taxes & fees
16 Dec - 17 Dec
DoubleTree by Hilton Chicago - Magnificent Mile
Reception
River Hotel

River Hotel

4.0 star property
The Loop, 4.6 km from Illinois Medical District
8.8 out of 10, Excellent, (4850)
"Location of the Hotel is very nice and the hotel is very clean."
United States
Khaing
The price is 2.151.221 ₫
2.525.319 ₫ total
includes taxes & fees
21 Dec - 22 Dec
River Hotel
Ballroom
Hilton Chicago/Magnificent Mile Suites

Hilton Chicago/Magnificent Mile Suites

3.5 star property
Streeterville, 5.6 km from Illinois Medical District
9.0 out of 10, Wonderful, (3450)
"Great place to stay "
United States
RaShawna
The price is 2.788.678 ₫
3.273.627 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hilton Chicago/Magnificent Mile Suites
Cocktail bar
Aloft Chicago Mag Mile

Aloft Chicago Mag Mile

3.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.6 out of 10, Excellent, (2956)
"Great location and great staff!!"
United States
lynne
The price is 2.188.129 ₫
2.568.646 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Aloft Chicago Mag Mile
Terrace/patio
Sable at Navy Pier Chicago, Curio Collection by Hilton

Sable at Navy Pier Chicago, Curio Collection by Hilton

4.0 star property
Streeterville, 6.4 km from Illinois Medical District
9.4 out of 10, Exceptional, (2261)
"Smooth check in and beautiful hotel"
United States
Monique
The price is 2.521.357 ₫
3.857.481 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Sable at Navy Pier Chicago, Curio Collection by Hilton
Bar (on property)
Hilton Garden Inn Chicago Downtown/Magnificent Mile

Hilton Garden Inn Chicago Downtown/Magnificent Mile

3.0 star property
River North, 4.7 km from Illinois Medical District
8.4 out of 10, Very good, (4235)
"Staff were amazing."
United States
Debra
The price is 2.161.766 ₫
2.537.697 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Hilton Garden Inn Chicago Downtown/Magnificent Mile
Exterior
Hilton Chicago

Hilton Chicago

4.0 star property
The Loop, 4.2 km from Illinois Medical District
8.4 out of 10, Very good, (2362)
"We had a great stay and will be back again."
United States
Amber
The price is 3.004.855 ₫
4.301.153 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton Chicago
Property amenity
citizenM Chicago Downtown

citizenM Chicago Downtown

4.0 star property
Theatre District, 4.6 km from Illinois Medical District
9.4 out of 10, Exceptional, (4099)
"I enjoyed my stay with this hotel and would stay here again"
United States
Kim Leticia Terrelle
The price is 2.820.841 ₫
3.311.386 ₫ total
includes taxes & fees
14 Dec - 15 Dec
citizenM Chicago Downtown
Exterior
FOUND Hotel Chicago River North

FOUND Hotel Chicago River North

2.0 star property
River North, 4.3 km from Illinois Medical District
8.4 out of 10, Very good, (366)
"love this place definitely coming back !"
United States
Dayanara
The price is 1.555.286 ₫
1.825.750 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
FOUND Hotel Chicago River North
Seasonal outdoor pool, open 8:00 AM to 10:00 PM, pool loungers
Holiday Inn & Suites Chicago - Downtown by IHG

Holiday Inn & Suites Chicago - Downtown by IHG

3.0 star property
West Loop, 3 km from Illinois Medical District
8.4 out of 10, Very good, (1008)
"Amazing staff clean and secure hotel "
United States
Aniyah
The price is 2.662.663 ₫
3.442.058 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Holiday Inn & Suites Chicago - Downtown by IHG
Front of property
Hotel Riu Plaza Chicago

Hotel Riu Plaza Chicago

4.0 star property
Streeterville, 5.1 km from Illinois Medical District
9.4 out of 10, Exceptional, (2945)
"Excellent stay great location and great rooms"
United States
Joseph
The price is 2.610.024 ₫
3.806.817 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Hotel Riu Plaza Chicago
Cocktail bar
Freehand Chicago

Freehand Chicago

4.0 star property
River North, 4.7 km from Illinois Medical District
8.0 out of 10, Very good, (2630)
"The room was spotless and the staff where great!"
United States
Maria
The price is 1.622.906 ₫
2.369.341 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Freehand Chicago
American cuisine
Crowne Plaza Chicago West Loop by IHG

Crowne Plaza Chicago West Loop by IHG

3.5 star property
2.7 km from Illinois Medical District
9.0 out of 10, Wonderful, (1749)
"The location was great!!"
United States
Yvette
The price is 2.254.036 ₫
2.646.013 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Crowne Plaza Chicago West Loop by IHG
Lobby
Silversmith Hotel Chicago Downtown

Silversmith Hotel Chicago Downtown

4.0 star property
Theatre District, 4.3 km from Illinois Medical District
9.2 out of 10, Wonderful, (2117)
"Would stay again. "
United States
Montroy
Silversmith Hotel Chicago Downtown
Rooftop terrace
Best Western River North Hotel

Best Western River North Hotel

2.5 star property
River North, 4.4 km from Illinois Medical District
7.8 out of 10, Good, (1025)
"Staff was very friendly "
United States
david
The price is 2.248.237 ₫
2.639.205 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western River North Hotel
Banquet hall
Congress Plaza Hotel

Congress Plaza Hotel

3.5 star property
The Loop, 4.2 km from Illinois Medical District
8.0 out of 10, Very good, (9645)
"Great stay comfortable bed and great location!"
United States
Kimberly Noel
The price is 3.181.750 ₫
3.735.055 ₫ total
includes taxes & fees
13 Dec - 14 Dec
Congress Plaza Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas for the activities you enjoy most.
Downtown Chicago featuring a city

Downtown Chicago

Known for its fascinating museums, stunning river views and gorgeous architecture, there's plenty to explore in Downtown Chicago. Top attractions like Michigan Avenue and Navy Pier are major draws. Catch the metro at State Station or Clark-Lake Station to see more of the city.

Magnificent Mile - River North

Magnificent Mile

Are you interested in fascinating museums, panoramic lake views and popular shops? A visit to Magnificent Mile might be the perfect thing. You can also explore top sights like Michigan Avenue and Chicago Water Tower.

The Loop - Downtown featuring a river or creek

The Loop

Michigan Avenue and Lake Michigan are a few top attractions in The Loop. Hop around the city on the metro at Washington Station or Lake Station and check out the area's fascinating museums, popular shops and acclaimed art galleries.

River North

Known for its fantastic nightlife, stunning river views and popular shops, there's plenty to explore in River North. Top attractions like Merchandise Mart and Bally's Casino Chicago are major draws. Catch the metro at Merchandise Mart Station or Chicago Station (Brown Line) to see more of the city.

Chicago which includes rides

Theatre District

While you're in Theatre District, take in top sights like Michigan Avenue or State Street, and hop on the metro to see more of the city at Washington Station or Monroe Station (Blue Line).

Top Illinois Medical District Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Illinois Medical District?
Guests are sure to enjoy their time checking out all that Chicago's Illinois Medical District neighbourhood has to offer.
How many hotels are there in the Illinois Medical District area?
If you're searching for places to stay in Chicago, choose from one of Expedia's 11 hotels and other accommodation options in Illinois Medical District.
If I need to cancel my hotel reservation in Illinois Medical District, will I receive a refund?
Yes, most room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, you might be able to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the top deals on offer in Illinois Medical District.
What can I see and do in this Chicago neighbourhood?
Don't miss favourite places to visit in the surrounding area, such as Michigan Avenue, United Center and Soldier Field. Michael Jordan Statue and National Museum of Mexican Art are also worth a visit when you're out sightseeing in Chicago.
How can I get around Illinois Medical District and the greater Chicago area?
Ready to get out and explore the city? Polk Station (Pink Line) is the closest metro station.