Mark Twain Holidays
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Where to stay in Mark Twain
Find the best Mark Twain areas and neighborhoods for the activities you enjoy most. Learn more about Mark Twain
Downtown St. Louis
4 out of top 10 points of interest in this area
4.5/5(18 area reviews)
Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.
Top hotels in Mark Twain
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 3.482.041 ₫ per night from 22 Feb to 23 Feb
3.482.041 ₫
4.201.345 ₫ total
22 Feb - 23 Feb
includes taxes & fees
9/10 Wonderful! (1,592 reviews)
Hotel was very quiet and staff helpful and courteous. The coffee shop was great for coffee and breakfast and the rooms were clean with hot water and great water pressure. The only thing I would change was the mattress - bed was very firm, kind of felt like lying on a table. Gallery was a fun feature ...
Reviewed on 3 Feb 2026
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 2.735.155 ₫ per night from 28 Feb to 1 Mar
2.735.155 ₫
3.192.965 ₫ total
28 Feb - 1 Mar
includes taxes & fees
8.8/10 Excellent! (3,089 reviews)
Only place I will stay in st louis- clean, nice facility, pleasant staff
Reviewed on 8 Feb 2026
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
The price is 2.336.680 ₫ per night from 16 Feb to 17 Feb
2.336.680 ₫
2.751.161 ₫ total
16 Feb - 17 Feb
includes taxes & fees
9.2/10 Wonderful! (2,808 reviews)
Staff was incredibly kind and helpful. They sent a shuttle to pick me up at the car rental place! The room was clean, the beds were comfortable, and the breakfast buffet had great options, even for our gluten-free family member.
Reviewed on 5 Feb 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
St. Louis Union Station
4.5/5(4 reviews)
You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Gateway Arch
5/5(16 reviews)
Find out about the history of Gateway Arch, one of the top monuments in St. Louis. Experience the area's great live music or attend a baseball game.
St. Louis Zoo
Why not visit the animals who live at St. Louis Zoo during your holiday in St. Louis? Amble around the area's lush forest or attend a sporting event.