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Our top choices for Mark Twain hotels

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
23.5 km from Mark Twain
8.4 out of 10, Very good, (1,006 reviews)
"Great hotel for the money"
United States
Jere
The price is 2.001.719 ₫
2.300.516 ₫ total
includes taxes & fees
22 Feb - 23 Feb
Comfort Suites St Charles - St Louis

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
4.0 star property
15.6 km from Mark Twain
8.8 out of 10, Excellent, (1,003 reviews)
"Great staff"
United States
irene
The price is 3.385.447 ₫
3.943.640 ₫ total
includes taxes & fees
1 Mar - 2 Mar
Hilton St. Louis Frontenac

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
23.4 km from Mark Twain
9.6 out of 10, Exceptional, (1,002 reviews)
"Great hotel "
United States
John Christopher
The price is 3.427.252 ₫
3.973.110 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Drury Plaza Hotel St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
24.4 km from Mark Twain
8.8 out of 10, Excellent, (1,005 reviews)
"A beautiful hotel. "
United States
Jon Michael
The price is 3.385.447 ₫
3.890.793 ₫ total
includes taxes & fees
22 Feb - 23 Feb
Embassy Suites by Hilton St. Louis St. Charles

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
23.8 km from Mark Twain
8.2 out of 10, Very good, (1,003 reviews)
"Amazing experience great staff and nice room "
United States
Kathy
The price is 2.033.657 ₫
2.357.559 ₫ total
includes taxes & fees
10 Feb - 11 Feb
Best Western Plus The Charles Hotel

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
27.8 km from Mark Twain
8.0 out of 10, Very good, (1,000 reviews)
"Great place to stay for the $$$"
United States
Kale
The price is 1.964.328 ₫
2.257.544 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Super 8 by Wyndham St Charles

Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO
2.5 star property
23.6 km from Mark Twain
8.6 out of 10, Excellent, (793 reviews)
"Clean, great breakfast options."
United States
Kristy
The price is 2.746.683 ₫
3.184.147 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Tru by Hilton St. Charles St. Louis, MO

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
23.2 km from Mark Twain
9.4 out of 10, Exceptional, (1,002 reviews)
"Wonderful place staff awesome "
United States
Chad
The price is 2.897.806 ₫
3.330.361 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Country Inn & Suites by Radisson, St. Charles Historic District

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
29.8 km from Mark Twain
8.0 out of 10, Very good, (1,005 reviews)
"Great location and friendly staff "
United States
Heather
The price is 2.533.762 ₫
2.911.977 ₫ total
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn St. Charles St. Peters

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach
2.5 star property
17 km from Mark Twain
8.0 out of 10, Very good, (609 reviews)
"Clean room, friendly staff, good breakfast "
United States
Saulius
The price is 1.565.750 ₫
1.772.699 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Red Lion Inn & Suites Pontoon Beach

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
23 km from Mark Twain
8.4 out of 10, Very good, (1,006 reviews)
"The room was great. I enjoyed my stay. "
United States
Wanda
The price is 5.117.899 ₫
6.412.823 ₫ total
includes taxes & fees
12 Feb - 13 Feb
Ameristar Casino Resort and Spa

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO
2.0 star property
15.8 km from Mark Twain
8.6 out of 10, Excellent, (1,745 reviews)
"Nice Stay!"
United States
Avalynn
The price is 1.370.745 ₫
1.675.586 ₫ total
includes taxes & fees
22 Feb - 23 Feb
Motel 6 Hazelwood, MO

Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66
3.5 star property
20 km from Mark Twain
8.4 out of 10, Very good, (1,417 reviews)
"The staff was amazing every time we interacted with them. "
United States
mary
The price is 2.441.843 ₫
2.856.663 ₫ total
includes taxes & fees
11 Feb - 12 Feb
Best Western St. Louis-Kirkwood Route 66

Hampton Inn & Suites St. Louis/Alton

Hampton Inn & Suites St. Louis/Alton
2.5 star property
26.5 km from Mark Twain
9.0 out of 10, Wonderful, (655 reviews)
"Breakfast menu was good with a variety to please everyone "
United States
Christopher
The price is 2.959.605 ₫
3.373.357 ₫ total
includes taxes & fees
19 Feb - 20 Feb
Hampton Inn & Suites St. Louis/Alton

Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City
2.0 star property
20.1 km from Mark Twain
8.6 out of 10, Excellent, (824 reviews)
"The rooms were spotless and the staff was great would definitley recommend "
United States
Trish
The price is 2.405.750 ₫
2.765.898 ₫ total
includes taxes & fees
1 Mar - 2 Mar
Sonesta Simply Suites St Louis Earth City

The Principal Hotel

The Principal Hotel
3.5 star property
27.7 km from Mark Twain
9.8 out of 10, Exceptional, (206 reviews)
"Great stay and very clean!"
United States
David
The price is 2.929.224 ₫
3.250.943 ₫ total
includes taxes & fees
12 Feb - 13 Feb
The Principal Hotel

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
12.6 km from Mark Twain
9.4 out of 10, Exceptional, (2,824 reviews)
"Great staff, clean, comfortable beds!"
United States
SUSAN
The price is 2.336.680 ₫
2.751.161 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Pear Tree Inn St. Louis Airport

Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
30.2 km from Mark Twain
8.2 out of 10, Very good, (1,003 reviews)
"Convenient spot for stopping through. Hallways smell a bit like cigarettes, room smelled a bit like body odor."
United States
James
The price is 2.196.204 ₫
2.524.536 ₫ total
includes taxes & fees
2 Mar - 3 Mar
Country Inn & Suites by Radisson, St. Peters, MO

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
27.9 km from Mark Twain
9.6 out of 10, Exceptional, (1,006 reviews)
"Great stay"
United States
Maureen
The price is 3.089.694 ₫
3.614.571 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Drury Inn & Suites Southwest St. Louis

Best Western Plus Pontoon Beach

Best Western Plus Pontoon Beach
3.0 star property
15.9 km from Mark Twain
8.6 out of 10, Excellent, (822 reviews)
"Everything was very nice"
United States
Todd
The price is 2.336.680 ₫
2.593.247 ₫ total
includes taxes & fees
15 Feb - 16 Feb
Best Western Plus Pontoon Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Mark Twain

Find the best Mark Twain areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

Central West End

If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Soulard

You'll enjoy the bars and churches in Soulard. You might want to make time for a stop at Anheuser-Busch Brewery or Soulard Farmer's Market.

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

Top Mark Twain Hotel Reviews

Frequently asked questions

What's it like in Mark Twain?
Travellers will be sure to find plenty to entertain them in St. Louis's Mark Twain neighbourhood.
If I need to cancel my hotel reservation in Mark Twain, will I receive a refund?
Yes, the majority of hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to review the best deals available in Mark Twain.
What is there to do around this St. Louis neighbourhood?
Bellefontaine Cemetery, Calvary Cemetery and Julia Davis Branch Library are just a few of the places to visit in and around Mark Twain. Shelley House and The Ville Monument are also worth a visit when you're out sightseeing in St. Louis.

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