Mayo Clinic Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix which includes signage and night scenes

Downtown Phoenix

3 out of top 10 points of interest in this area
4/5(25 area reviews)

Known for its ample dining options and great live music, there's plenty to explore in Downtown Phoenix. You can visit top attractions like Chase Field and Mortgage Matchup Center, and jump on the metro at 12th Street - Jefferson Station or 12th Street - Washington Station to see more of the city.

Find hotels in Downtown Phoenix

Top hotels in Mayo Clinic

Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

4 out of 5
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
The price is 3.845.409 ₫ per night from 12 Apr to 13 Apr
3.845.409 ₫
5.502.048 ₫ total
12 Apr - 13 Apr
includes taxes & fees
8.6/10 Excellent! (2,454 reviews)
The Falls was the kid’s favorite spot during the day. Made good use of the pickleball courts in the evening and the family pool for a later dip in the water. In-room service was great. Everyone was helpful an attentive. Great overall!

Reviewed on 18 Mar 2026

Hilton Phoenix Tapatio Cliffs Resort
Hilton Phoenix Resort at the Peak

Hilton Phoenix Resort at the Peak

4 out of 5
7677 N 16th St Phoenix AZ
Fully refundableReserve now, pay when you stay
The price is 5.410.596 ₫ per night from 5 Apr to 6 Apr
5.410.596 ₫
7.153.507 ₫ total
5 Apr - 6 Apr
includes taxes & fees
7.6/10 Good! (3,222 reviews)
super friendly staff all around! water park was a hit with our daughter. Only downside was parking & construction but other than that was great!

Reviewed on 17 Mar 2026

Hilton Phoenix Resort at the Peak
Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way Scottsdale AZ
Fully refundableReserve now, pay when you stay
The price is 4.471.589 ₫ per night from 12 Apr to 13 Apr
4.471.589 ₫
5.847.977 ₫ total
12 Apr - 13 Apr
includes taxes & fees
9.2/10 Wonderful! (4,486 reviews)
It was horrible. We were bitten by bed bugs and had to be examined my EMTs. They would not compensate us for the room and are making us go through their insurance investigator. They did not even offer an apology and wont let us see a copy of the report unless we subpoena the Tribal Nation. A truly ...

Reviewed on 18 Mar 2026

Talking Stick Resort
See all 13,239 properties in Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mayo Clinic holiday package cost?
Starting from as low as , a package is your gateway to low-priced travel. Customize your Mayo Clinic trip by choosing from our extensive range of hotels, flights and rental cars.
How do I get a cheap travel package to Mayo Clinic?
Our Mayo Clinic holiday packages promise plenty of savings for the savvy globetrotter. For the best deals, simply combine your flights, hotels and activities into an affordable package. But low prices are just the beginning of your next unforgettable adventure. Book with Expedia and and you'll have over 550 airlines and 1null000null000 properties throughout the world to pick from. No matter your budget or style, there's a holiday package that's perfect for you.
Where should I stay in Mayo Clinic?
Cross Tournament Players Club of Scottsdale off your must-see list and then stay right near it. Soak up the exciting vibe around this terrific attraction and drop by whenever the mood strikes!
What are the top hotels in Mayo Clinic?
Whether you plan to stay for a night or a week in Mayo Clinic, you'll get a great night's rest at Sonesta Select Scottsdale at Mayo Clinic Campus. This option is popular with plenty of travellers.
How far in advance should I book my Mayo Clinic holiday?
Search Expedia to compare international flights as early as possible. In most cases, you can purchase a seat up to 12 months prior to departure. If it's too early for your preferred carrier, or you have to book last minute, don't despair. Cheap fares to Mayo Clinic sometimes occur within weeks of departure.
What does an Expedia Mayo Clinic travel package include?
It all depends on what sort of trip you have in the works. Mayo Clinic holiday deals can include car rentals, hotels and flights. You can mix and match to find the travel package that suits your style and budget. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Mayo Clinic travel package?
When you book your flights, hotels and car rentals together, you'll walk away with awesome discounts. Whether you're planning a beach break in a villa or want to stay in a fancy hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Mayo Clinic Expedia holiday package?
You can, and with over 550 airlines to choose from all over the world, you've got lots of choice. Take a look at the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mayo Clinic holiday package?
You sure can, and we'll help you every step of the way. You may be able to cancel and rebook your Mayo Clinic holiday package at no cost if you booked in the last 24 hours. But you may incur a fee from your hotel, airline or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, have a look at our Customer Service Portal for further information.

Popular places to visit

Phoenix Convention Center

Phoenix Convention Center

3.5/5(2 reviews)

During your trip, find out what's happening in Phoenix Convention Center, a top convention centre in Phoenix. Experience the acclaimed art galleries and fascinating museums in this vibrant area.

Phoenix Convention Center
Chase Field

Chase Field

4.5/5(10 reviews)

Catch an event at Chase Field and enjoy other activities in Phoenix such as golfing.In the area, take in the acclaimed art galleries and desert landscapes.

Chase Field
Phoenix_TalkingStickResortCasino_553248621555612463_02

Talking Stick Resort Casino

Why not try your luck with a visit to Talking Stick Resort Casino where you can enjoy the entertainment at this popular casino in Scottsdale? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Talking Stick Resort Casino