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Check availability on Mission District Boutique Hotels

Our top choices for Mission District boutique hotels

Indoor pool
Berkeley City Club

Berkeley City Club

Berkeley City Club
2.5 star property
Telegraph District
8.8 out of 10, Excellent, (696)
"Wonderful, beautiful, old world hotel, right in the heart of bustling Berkeley. "
United States
Peter
Berkeley City Club
Games room
Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
Fisherman's Wharf
8.6 out of 10, Excellent, (2321)
"Excellent location."
United States
Rena
The price is 3.519.591 ₫
5.073.225 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Zephyr San Francisco
Premium bedding, pillow-top beds, in-room safe, desk
Inn At Union Square

Inn At Union Square

Inn At Union Square
3.5 star property
Union Square
9.2 out of 10, Wonderful, (1002)
"Clean room, welcoming staff, we would stay again. "
United States
Natalie
The price is 2.729.295 ₫
3.871.380 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Inn At Union Square
Lobby sitting area
The Marker Union Square San Francisco

The Marker Union Square San Francisco

The Marker Union Square San Francisco
4.0 star property
Union Square
9.0 out of 10, Wonderful, (1096)
"Very courteous staff, rooms & amenities clean, comfortable bed"
Australia
Inna
The price is 3.539.098 ₫
4.165.342 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
The Marker Union Square San Francisco
Exterior
Hotel Emblem San Francisco

Hotel Emblem San Francisco

Hotel Emblem San Francisco
4.0 star property
Union Square
9.4 out of 10, Exceptional, (1001)
"Nice room, helpful staff and great location. "
United States
Okan
The price is 3.479.784 ₫
5.150.539 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Hotel Emblem San Francisco
Lobby
The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1001)
"cleanliness,good service, convenient location"
United States
Harry
The price is 4.220.029 ₫
6.059.147 ₫ total
includes taxes & fees
29 Dec - 30 Dec
The Clancy, Autograph Collection by Marriott
Exterior
Argonaut Hotel

Argonaut Hotel

Argonaut Hotel
4.5 star property
Fisherman's Wharf
9.4 out of 10, Exceptional, (1199)
"Great location, excellent staff."
United States
Walter
The price is 4.982.348 ₫
6.981.194 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Argonaut Hotel
Meeting facility
The Barnes San Francisco, Tapestry Collection by Hilton

The Barnes San Francisco, Tapestry Collection by Hilton

The Barnes San Francisco, Tapestry Collection by Hilton
4.0 star property
Union Square
8.2 out of 10, Very good, (764)
"Great location, friendly staff."
Canada
Lucy
The price is 3.216.164 ₫
3.785.263 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Barnes San Francisco, Tapestry Collection by Hilton
Suite, Multiple Beds (The Two Bedroom) | Egyptian cotton sheets, premium bedding, pillow-top beds, minibar
Palihotel San Francisco

Palihotel San Francisco

Palihotel San Francisco
3.5 star property
Union Square
8.4 out of 10, Very good, (624)
"Great vibe here and the rooms and so cute . Excellent bar and bar staff . "
United States
Lana
The price is 2.637.000 ₫
3.762.999 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Palihotel San Francisco
City view
Taj Campton Place

Taj Campton Place

Taj Campton Place
5.0 star property
Union Square
9.2 out of 10, Wonderful, (1001)
"Wonderful Staff and hospitality."
United States
Rachel
The price is 4.692.436 ₫
6.433.119 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Taj Campton Place
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mission District Hotel Reviews

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Frequently asked questions

What's there to see and do in Mission District?
The bars is one thing to enjoy while you're in the area. Favorite activities and sights around Mission District include Chase Center, Oracle Park and Pier 39. Some other things you might want to enjoy include SF Armory, SOMA Pilipinas and Marsh Theater.
What's the best way to get to my boutique hotel in Mission District?
You have a few options for getting to Mission District. The closest major airport is San Francisco International Airport (SFO), which is located 10 mi (16.1 km) away. Take advantage of metro transport at 16th Street Mission Station, 24th Street Mission Station and Right Of Way/20th St Stop.