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25 Dec - 26 Dec
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Our top choices for Museum of Life and Science hotels

Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
1.4 km from Museum of Life and Science
9.0 out of 10, Wonderful, (1001)
"Clean rooms and courteous staff."
United States
Katina
The price is 2.783.706 ₫
3.159.506 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.2 km from Museum of Life and Science
8.8 out of 10, Excellent, (957)
"We arrived at 12:25am. We were welcomed warmly and it was a very nice and pleasant check-in. The staff member that checked us in was so great. "
United States
Timothy
The price is 2.552.652 ₫
2.897.392 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Durham by IHG
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.2 km from Museum of Life and Science
8.6 out of 10, Excellent, (1000)
"Friendly staff, clean room, nice breakfast"
United States
Jessica
The price is 2.383.745 ₫
2.705.550 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn & Suites Durham near Duke University
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.2 km from Museum of Life and Science
6.8 out of 10, (1000)
"Good motel...clean, easy acess "
United States
Howard
The price is 1.527.407 ₫
1.778.410 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Red Roof Inn Durham - Duke Univ Medical Center
Reception
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
4.8 km from Museum of Life and Science
9.6 out of 10, Exceptional, (401)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is 2.999.761 ₫
3.404.727 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Hampton Inn & Suites Durham University Medical Center
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 3.4 km from Museum of Life and Science
9.2 out of 10, Wonderful, (1000)
"Just right for an overnight business trip "
United States
Cody
The price is 2.532.915 ₫
2.874.859 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Durham/University Medical Center
Indoor pool
Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
5.9 km from Museum of Life and Science
9.4 out of 10, Exceptional, (1005)
"Beautiful hotel. The staff is fabulous! Went out of their way to make our stay memorable."
United States
Lisa
The price is 4.210.560 ₫
4.778.984 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Washington Duke Inn & Golf Club
Terrace/patio
JB Duke Hotel

JB Duke Hotel

JB Duke Hotel
4.0 star property
5.6 km from Museum of Life and Science
9.4 out of 10, Exceptional, (543)
"Excellent on all levels! Will definitely stay here again!"
United States
Cherie Nan
The price is 3.917.359 ₫
4.446.202 ₫ total
includes taxes & fees
28 Dec - 29 Dec
JB Duke Hotel
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 3.3 km from Museum of Life and Science
9.2 out of 10, Wonderful, (460)
"Hotel was great - very friendly staff."
United States
Lisa
The price is 3.523.502 ₫
3.999.175 ₫ total
includes taxes & fees
25 Jan - 26 Jan 2026
Residence Inn Durham McPherson/Duke University Medical Cntr
Garden
Arrowhead Inn

Arrowhead Inn

Arrowhead Inn
4.5 star property
9.8 km from Museum of Life and Science
9.8 out of 10, Exceptional, (119)
"Bed was very comfortable, breakfast was yummy, and the surroundings were beautiful"
United States
Ronald
The price is 5.163.199 ₫
5.860.047 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Arrowhead Inn
BBQ/picnic Area
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
4.9 km from Museum of Life and Science
9.2 out of 10, Wonderful, (619)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is 3.109.235 ₫
3.528.982 ₫ total
includes taxes & fees
28 Dec - 29 Dec
AC Hotel Durham
Terrace/patio
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
4.6 km from Museum of Life and Science
9.2 out of 10, Wonderful, (455)
"Yess the room was spotless and clean the check in was smooth "
United States
Vonisha
The price is 2.710.548 ₫
3.076.472 ₫ total
includes taxes & fees
28 Dec - 29 Dec
SpringHill Suites by Marriott Durham City View
Premium bedding, desk, blackout curtains, iron/ironing board
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 3.6 km from Museum of Life and Science
9.0 out of 10, Wonderful, (642)
"Great stay. Very nice boutique hotel. "
United States
nadav
The price is 4.895.039 ₫
5.555.870 ₫ total
includes taxes & fees
28 Dec - 29 Dec
The Durham Hotel
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.1 km from Museum of Life and Science
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is 4.894.776 ₫
5.555.571 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Aloft Durham Downtown
Front of property – evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
4 km from Museum of Life and Science
8.8 out of 10, Excellent, (1000)
"Great place"
United States
Chase
The price is 3.000.024 ₫
3.405.290 ₫ total
includes taxes & fees
26 Dec - 27 Dec
University Inn Durham next to Duke University Medical Center
Daily cooked-to-order breakfast (USD 19.95 per person)
Durham Marriott City Center

Durham Marriott City Center

Durham Marriott City Center
3.5 star property
Downtown Durham, 3.6 km from Museum of Life and Science
8.8 out of 10, Excellent, (824)
"The room was clean. The staff was very helpful and the food was good. "
United States
Tia
The price is 3.342.132 ₫
3.793.319 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Durham Marriott City Center
Property grounds
Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel
4.0 star property
16.3 km from Museum of Life and Science
9.6 out of 10, Exceptional, (1001)
"Breakfast was fabulous!"
United States
Cindy
The price is 3.578.976 ₫
4.062.136 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Rizzo Center, a Destination by Hyatt Hotel
Outdoor pool, pool loungers
Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint
3.0 star property
15.3 km from Museum of Life and Science
9.4 out of 10, Exceptional, (1004)
"Beautiful room and very clean. Staff were extremely nice on each shift. Will stay here again!"
United States
Jacoby
The price is 3.210.552 ₫
3.643.977 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hyatt Place Durham Southpoint
Front of property
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

The Lodge at Duke Medical Center
3.0 star property
4 km from Museum of Life and Science
8.4 out of 10, Very good, (1000)
"Room was clean and great customer service. "
United States
Anne
The price is 3.394.764 ₫
3.853.056 ₫ total
includes taxes & fees
26 Dec - 27 Dec
The Lodge at Duke Medical Center
Seasonal outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas
Hilton Durham near Duke University

Hilton Durham near Duke University

Hilton Durham near Duke University
3.5 star property
5.2 km from Museum of Life and Science
8.4 out of 10, Very good, (1001)
"Great stay"
United States
Daniel
The price is 2.567.915 ₫
2.914.583 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Hilton Durham near Duke University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Museum of Life and Science Hotel Reviews

Hotels near other Museum of Life and Science attractions

Brightleaf Square

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
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Vietnam Veterans Living Memorial

You can find out about the history of Durham with a trip to Vietnam Veterans Living Memorial. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
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Frequently asked questions

What's the area like around Museum of Life and Science?
Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 10 hotels and other accommodation options you'll find within a mile.
How many hotels can I expect to find close to Museum of Life and Science?
Expedia has 10 hotels and other accommodation options within a mile from Museum of Life and Science.
If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Museum of Life and Science.
What can I see and do near Museum of Life and Science?
You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.