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Our top choices for Museum of Life and Science hotels

Free daily buffet breakfast
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
1.4 km from Museum of Life and Science
9.0 out of 10, Wonderful, (1003)
"Clean rooms and courteous staff."
United States
Katina
The price is 2.785.293 ₫
3.161.309 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.2 km from Museum of Life and Science
8.8 out of 10, Excellent, (957)
"We arrived at 12:25am. We were welcomed warmly and it was a very nice and pleasant check-in. The staff member that checked us in was so great. "
United States
Timothy
The price is 2.554.107 ₫
2.899.043 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Durham by IHG
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.2 km from Museum of Life and Science
8.6 out of 10, Excellent, (1000)
"Friendly staff, clean room, nice breakfast"
United States
Jessica
The price is 2.462.136 ₫
2.794.526 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn & Suites Durham near Duke University
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.2 km from Museum of Life and Science
6.8 out of 10, (1000)
"Good motel...clean, easy acess "
United States
Howard
The price is 1.528.277 ₫
1.779.424 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Red Roof Inn Durham - Duke Univ Medical Center
Carolina Log Cabin | Terrace/patio
Arrowhead Inn

Arrowhead Inn

Arrowhead Inn
4.5 star property
9.8 km from Museum of Life and Science
9.8 out of 10, Exceptional, (119)
"Bed was very comfortable, breakfast was yummy, and the surroundings were beautiful"
United States
Ronald
The price is 5.166.142 ₫
5.863.387 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Arrowhead Inn
Terrace/patio
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
4.8 km from Museum of Life and Science
9.6 out of 10, Exceptional, (400)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is 3.001.471 ₫
3.406.670 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Hampton Inn & Suites Durham University Medical Center
Exterior
JB Duke Hotel

JB Duke Hotel

JB Duke Hotel
4.0 star property
5.6 km from Museum of Life and Science
9.4 out of 10, Exceptional, (543)
"Excellent on all levels! Will definitely stay here again!"
United States
Cherie Nan
The price is 3.919.592 ₫
4.448.736 ₫ total
includes taxes & fees
25 Dec - 26 Dec
JB Duke Hotel
Front of property
Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
5.9 km from Museum of Life and Science
9.4 out of 10, Exceptional, (1003)
"Everything fabulous!"
United States
Terri
The price is 4.212.960 ₫
4.781.710 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Washington Duke Inn & Golf Club
Property grounds
Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel
4.0 star property
16.3 km from Museum of Life and Science
9.6 out of 10, Exceptional, (1001)
"Breakfast was fabulous!"
United States
Cindy
The price is 3.581.016 ₫
4.064.453 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Rizzo Center, a Destination by Hyatt Hotel
Restaurant
The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel
4.0 star property
18.9 km from Museum of Life and Science
9.6 out of 10, Exceptional, (265)
"The room was great. Very clean. The staff was absolutely amazing! 10 out of 10! "
United States
Stuart
The price is 3.536.253 ₫
4.013.649 ₫ total
includes taxes & fees
14 Jan - 15 Jan 2026
The Colonial Inn, an Ascend Collection Hotel
Reception
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 3.4 km from Museum of Life and Science
9.2 out of 10, Wonderful, (1001)
"Just right for an overnight business trip "
United States
Cody
The price is 2.519.541 ₫
2.859.678 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hilton Garden Inn Durham/University Medical Center
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 3.3 km from Museum of Life and Science
9.2 out of 10, Wonderful, (460)
"Hotel was great - very friendly staff."
United States
Lisa
The price is 3.684.234 ₫
4.181.606 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Residence Inn Durham McPherson/Duke University Medical Cntr
Exterior
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
4.6 km from Museum of Life and Science
9.2 out of 10, Wonderful, (455)
"Yess the room was spotless and clean the check in was smooth "
United States
Vonisha
The price is 2.712.299 ₫
3.078.461 ₫ total
includes taxes & fees
28 Dec - 29 Dec
SpringHill Suites by Marriott Durham City View
Lobby
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
4.9 km from Museum of Life and Science
9.2 out of 10, Wonderful, (617)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is 3.111.008 ₫
3.530.993 ₫ total
includes taxes & fees
29 Dec - 30 Dec
AC Hotel Durham
Outdoor pool, pool loungers
Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint

Hyatt Place Durham Southpoint
3.0 star property
15.3 km from Museum of Life and Science
9.4 out of 10, Exceptional, (1003)
"Beautiful room and very clean. Staff were extremely nice on each shift. Will stay here again!"
United States
Jacoby
The price is 3.212.382 ₫
3.646.054 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hyatt Place Durham Southpoint
Lobby
Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek
2.5 star property
17.5 km from Museum of Life and Science
9.4 out of 10, Exceptional, (1000)
"Wonderful hotel "
United States
Robert
The price is 2.893.470 ₫
3.276.856 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek
Seasonal outdoor pool
The Westin Raleigh-Durham Airport

The Westin Raleigh-Durham Airport

The Westin Raleigh-Durham Airport
4.0 star property
17.4 km from Museum of Life and Science
9.4 out of 10, Exceptional, (280)
"Besides the last day of no electricity for the most part good stay"
United States
Chandra
The price is 5.424.186 ₫
6.142.891 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
The Westin Raleigh-Durham Airport
Outdoor dining
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 3.6 km from Museum of Life and Science
9.0 out of 10, Wonderful, (642)
"Great stay. Very nice boutique hotel. "
United States
nadav
The price is 4.897.829 ₫
5.559.035 ₫ total
includes taxes & fees
27 Dec - 28 Dec
The Durham Hotel
Meeting facility
The Carolina Inn, a Destination by Hyatt Hotel

The Carolina Inn, a Destination by Hyatt Hotel

The Carolina Inn, a Destination by Hyatt Hotel
4.5 star property
19.3 km from Museum of Life and Science
9.6 out of 10, Exceptional, (1001)
"Very clean room and the staff was outstanding. One of the better hotel staff that I jave experience in my travels"
United States
Shaun
The price is 6.056.130 ₫
6.873.708 ₫ total
includes taxes & fees
27 Dec - 28 Dec
The Carolina Inn, a Destination by Hyatt Hotel
Front of property
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.1 km from Museum of Life and Science
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is 4.686.918 ₫
5.319.651 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Aloft Durham Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Museum of Life and Science Hotel Reviews

Hotels near other Museum of Life and Science attractions

Brightleaf Square

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
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Vietnam Veterans Living Memorial

You can find out about the history of Durham with a trip to Vietnam Veterans Living Memorial. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
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Frequently asked questions

What's the area like around Museum of Life and Science?
Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 10 hotels and other accommodation options you'll find within a mile.
How many hotels can I expect to find close to Museum of Life and Science?
Expedia has 10 hotels and other accommodation options within a mile from Museum of Life and Science.
If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Museum of Life and Science.
What can I see and do near Museum of Life and Science?
You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.