North Clayton Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in North Clayton

Find the best North Clayton areas and neighborhoods for the activities you enjoy most. Learn more about North Clayton
Meeting of the Waters Fountain showing a statue or sculpture and a fountain

Downtown St. Louis

4 out of top 10 points of interest in this area
4.5/5(18 area reviews)

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

Find hotels in Downtown St. Louis

Top hotels in North Clayton

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
216 N Meramec Ave St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 3.064.058 ₫ per night from 26 Feb to 27 Feb
3.064.058 ₫
3.607.562 ₫ total
26 Feb - 27 Feb
includes taxes & fees
8.8/10 Excellent! (934 reviews)
Pleasant and professional staff. Updated property and was incredibly clean!

Reviewed on 29 Jan 2026

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 3.295.693 ₫ per night from 23 Feb to 24 Feb
3.295.693 ₫
3.983.721 ₫ total
23 Feb - 24 Feb
includes taxes & fees
9/10 Wonderful! (1,580 reviews)
Very nice and clean

Reviewed on 29 Jan 2026

21C Museum Hotel St Louis
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 2.733.364 ₫ per night from 28 Feb to 1 Mar
2.733.364 ₫
3.190.874 ₫ total
28 Feb - 1 Mar
includes taxes & fees
8.8/10 Excellent! (3,076 reviews)
Room comfortable and clean. Dtaff very polite, professional, and helpful.

Reviewed on 25 Jan 2026

Clayton Plaza Hotel & Extended Stay
See all 1,816 properties in North Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a North Clayton holiday package cost?
From as little as . Yes, you read that correctly. Our North Clayton holiday packages are the best way to make your budget stretch further. Bundle your hotels, flights and car rentals and discover this top destination.
How do I get a cheap travel package to North Clayton?
Our North Clayton holiday packages mean plenty of savings for the savvy explorer. For the best deal, simply bundle your flights, hotels and activities into a neat and tidy package. But bargain prices are only the start of your next memorable adventure. When you book with Expedia, and you'll have over 550 airlines and 1null000null000 hotel options around the globe to select from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in North Clayton?
Urban adventurers come from near and far to experience St. Louis Zoo and Cathedral Basilica of St. Louis in North Clayton. Book a hotel within walking distance of these top attractions to make sightseeing a breeze.
What are the top hotels in North Clayton?
When it comes to comfortable and convenient places to stay in North Clayton, you can't go past Hampton Inn & Suites Clayton/St. Louis-Galleria Area. Be sure to browse our deals and score a great price.
How far in advance should I book my North Clayton holiday?
Your safest bet is to book early. Airlines typically advertise flight tickets around a year prior to departure, and this is an excellent opportunity to land some of the cheapest prices. Boss just told you to take all your holiday days next week? No problem! Expedia are never short of fantastic bargains to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia North Clayton travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle hotels and flights. Bringing the whole crew to North Clayton? A travel package including hotels, flights and rental cars might be a better fit. Expedia gives you the freedom to tailor your travel package.
What should I know before booking a North Clayton travel package?
So many places to visit, so many things to experience. With a travel package, you'll be able to afford more of them. Bundle your hotels, rental cars and flights and land big savings.
Can I choose my airline with a North Clayton Expedia holiday package?
You sure can. We offer more than 550 partner airlines across the globe, so go with the carrier that best suits your budget and travel needs.
If I'm not able to travel, can I cancel my North Clayton holiday package?
Certainly, and we'll help you every step of the way. You may be able to cancel or change your North Clayton holiday package at no cost if you booked in the last 24 hours. But you may be charged a fee by your airline, hotel or car rental company if your booking is older than that. If your circumstances suddenly change, visit our Customer Service Portal for more information.

Popular places to visit

Union Station, St. Louis, MO

St. Louis Union Station

4.5/5(4 reviews)

You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's acclaimed art galleries or attend a baseball game.

St. Louis Union Station
Gateway Arch showing a city, city views and skyline

Gateway Arch

5/5(16 reviews)

Find out about the history of Gateway Arch, one of the top monuments in St. Louis. Experience the area's acclaimed art galleries or attend a baseball game.

Gateway Arch
St. Louis Zoo

St. Louis Zoo

Why not visit the animals who live at St. Louis Zoo during your holiday in St. Louis? Amble around the area's lush forest or attend a sporting event.

St. Louis Zoo