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28 Aug - 30 Aug
Next weekend
4 Sep - 6 Sep

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Our top choices for Otay Mesa hotels

A Holiday Inn Express hotel with a modern design, featuring a spacious entrance, palm trees, and a well-lit facade.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,863 reviews)
"Happy with are stay"
United States
Yaril
The price is 3.584.194 ₫
4.077.020 ₫ total
includes taxes & fees
24 Sept - 25 Sept
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A breakfast station with bread, bagels, waffles, and a coffee machine.

2. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,018 reviews)
"Very quiet and friendly staff excellent breakfast"
United States
Mia
The price is 2.806.164 ₫
3.192.011 ₫ total
includes taxes & fees
20 Sept - 21 Sept
Quality Suites San Diego Otay Mesa
An outdoor patio area with seating and a bar.

3. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,089 reviews)
"Love it! Amazing stay! Will book again for our next trip."
United States
Evelyn
The price is 4.559.854 ₫
5.024.719 ₫ total
includes taxes & fees
7 Sept - 8 Sept
Ayres Hotel San Diego South - Chula Vista
A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.

4. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,060 reviews)
"Great stay!"
United States
Samuel
The price is 3.737.461 ₫
4.118.495 ₫ total
includes taxes & fees
7 Sept - 8 Sept
Best Western Plus Marina Gateway Hotel
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

5. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,660 reviews)
"Great hotel to stay."
United States
Katsuya
The price is 2.905.927 ₫
3.202.332 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Comfort Inn Chula Vista San Diego South
A swimming pool with palm trees and a mountain in the background.

6. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,117 reviews)
"The golf courses and hotel were great!"
United States
Tom
The price is 3.240.996 ₫
3.878.488 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Sycuan Casino Resort
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

7. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,737 reviews)
"great STAFF , always helpful , friendly , great place to stay"
United States
Luis
The price is 2.730.428 ₫
3.003.471 ₫ total
includes taxes & fees
7 Sept - 8 Sept
La Quinta Inn by Wyndham San Diego Chula Vista
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

8. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,380 reviews)
"Great stay"
United States
Luis
The price is 2.964.688 ₫
3.372.333 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Best Western Americana Inn
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

9. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,465 reviews)
"Good breakfast, friendly staff and great housekeeping."
United States
Jose
The price is 3.573.975 ₫
3.931.372 ₫ total
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express San Diego South - Chula Vista by IHG
A multi-story hotel with a prominent entrance, a stone facade, and a clear sky.

10. WoodSpring Suites Santee - San Diego Northeast

WoodSpring Suites Santee - San Diego Northeast
2.5 star property
30.9 km from Otay Mesa
8.4 out of 10, Very good, (228 reviews)
"Great place to stay"
United States
Adan
The price is 2.716.064 ₫
2.987.670 ₫ total
includes taxes & fees
26 Aug - 27 Aug
WoodSpring Suites Santee - San Diego Northeast

11. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (746 reviews)
"Fairly new, big, clean rooms and good breakfast"
United Kingdom
Thomas
The price is 5.143.285 ₫
5.667.642 ₫ total
includes taxes & fees
7 Sept - 8 Sept
SpringHill Suites by Marriott Chula Vista Eastlake
A motel sign with a directional arrow and a number '6' indicating the entrance.

12. Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,780 reviews)
"Disgusting hotel with crackheads and homeless people"
United States
Juan
The price is 1.746.116 ₫
2.001.008 ₫ total
includes taxes & fees
31 Aug - 1 Sept
Motel 6 El Cajon, CA - San Diego
A spacious lobby with a large seating area, a wooden ceiling, and large windows offering a view of the outdoor patio area.

13. Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,716 reviews)
"Very happy with the overall stay. Very efficient procedure from check in to check out."
United States
Ivan
The price is 4.261.609 ₫
4.898.507 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Hampton Inn & Suites San Diego Airport Liberty Station
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

14. The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,228 reviews)
"Just a great place to stay!"
United States
Tracy
The price is 2.941.096 ₫
3.637.955 ₫ total
includes taxes & fees
23 Sept - 24 Sept
The Rambler Hotel
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

15. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,499 reviews)
"Great hotel,"
United States
Keane
The price is 2.293.743 ₫
2.527.590 ₫ total
includes taxes & fees
22 Sept - 23 Sept
Hercor Hotel - Urban Boutique
A balcony with wicker furniture overlooking a marina and a coastal cityscape.

16. Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.6 out of 10, Excellent, (3,681 reviews)
"Very close to most restaurants and activities 💪👌"
United States
Morne De
The price is 3.969.632 ₫
5.883.841 ₫ total
includes taxes & fees
3 Sept - 4 Sept
Sheraton San Diego Resort
A modern restaurant with a bar area, dining tables, and chairs.

17. Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
26.3 km from Otay Mesa
9.2 out of 10, Wonderful, (1,003 reviews)
"Updated property, helpful staff, close to quality restaurants. Parking was responsible. Good experience at this property"
United States
Carl
The price is 4.060.516 ₫
4.474.485 ₫ total
includes taxes & fees
7 Sept - 8 Sept
Courtyard by Marriott San Diego El Cajon
A spacious living room with a large arched window, a red sofa, a coffee table, and a chandelier.

18. Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,422 reviews)
"Great stay"
United States
Bernadette
The price is 3.187.719 ₫
3.594.084 ₫ total
includes taxes & fees
21 Sept - 22 Sept
Lamplighter Inn & Suites at SDSU
A reception area with a stone archway, a reception desk, and potted plants.

19. Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,100 reviews)
"Very good hotel at the price with good choice of breakfast."
United States
Tirthankar
The price is 3.682.356 ₫
4.232.683 ₫ total
includes taxes & fees
31 Aug - 1 Sept
Holiday Inn Express San Diego Airport - Old Town by IHG
A modern lobby with a stone wall, blue sofas, a reception desk, and a staircase.

20. Kings Inn San Diego

Kings Inn San Diego
2.5 star property
29.1 km from Otay Mesa
8.8 out of 10, Excellent, (3,760 reviews)
"Great place to stay"
United States
Manuel
The price is 2.403.895 ₫
2.758.469 ₫ total
includes taxes & fees
20 Sept - 21 Sept
Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A beach with surfers and swimmers during sunset.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

10/10 Excellent
"Great time and excellent breakfast!"
Willisha 2-night trip
Posted 1 hour ago
Manchester Grand Hyatt San Diego

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.