Otay Mesa Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Seaport Village and Petco Park are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is 3.986.482 ₫ per night from 20 Jul to 21 Jul
3.986.482 ₫
5.381.956 ₫ total
20 Jul - 21 Jul
includes taxes & fees
8.2/10 Very Good! (5,716 reviews)
"we had a bay view which was excellent"

Reviewed on 2 Jul 2025

Wyndham San Diego Bayside
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 5.768.150 ₫ per night from 20 Jul to 21 Jul
5.768.150 ₫
7.879.259 ₫ total
20 Jul - 21 Jul
includes taxes & fees
9/10 Wonderful! (1,723 reviews)
"Excellent"

Reviewed on 3 Jul 2025

Marriott Marquis San Diego Marina
Handlery Hotel
Handlery Hotel
3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 3.277.745 ₫ per night from 21 Jul to 22 Jul
3.277.745 ₫
3.767.605 ₫ total
21 Jul - 22 Jul
includes taxes & fees
8/10 Very Good! (1,839 reviews)
Greed
"Paying 24 dollars a night for parking is a total rip off!! They are making some serious cash charging that. Greedy owners!!"

Reviewed on 29 Jun 2025

Handlery Hotel
See all 4,576 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as , a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1null000null000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package --- it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

4.5/5(47 reviews)

Why not visit the animals who live at San Diego Zoo and see why this is a popular attraction in San Diego? Stroll along the area's seaside or experience its fascinating museums.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4/5(18 reviews)

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.

San Diego Convention Center
Mission Bay featuring a beach

Mission Bay

4.5/5(31 reviews)

Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the seaside in this family-friendly area or visit its top-notch restaurants.

Mission Bay