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16 Dec - 17 Dec
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17 Dec - 18 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Sant' Ambrogio hotels

View from property
Hotel Cardinal Of Florence

Hotel Cardinal Of Florence

Hotel Cardinal Of Florence
3.0 star property
Sant' Ambrogio
8.6 out of 10, Excellent, (313)
"Booked this hotel for the view on the rooftop and it did not disappoint. Also great loccation."
Canada
Ed
The price is 1.890.102 ₫
2.449.720 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel Cardinal Of Florence
Restaurant
Hotel Bodoni

Hotel Bodoni

Hotel Bodoni
2.0 star property
Sant' Ambrogio
8.2 out of 10, Very good, (792)
"Nice people and convenient location!!!!"
United States
julio
The price is 1.973.653 ₫
2.449.354 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Hotel Bodoni
View from property
B&B di Piazza del Duomo

B&B di Piazza del Duomo

B&B di Piazza del Duomo
Sant' Ambrogio
9.2 out of 10, Wonderful, (245)
"great location."
Australia
Ankur
The price is 2.633.480 ₫
3.267.529 ₫ total
includes taxes & fees
22 Dec - 23 Dec
B&B di Piazza del Duomo
Interior entrance
Hotel D'Azeglio

Hotel D'Azeglio

Hotel D'Azeglio
2.0 star property
Sant' Ambrogio
7.8 out of 10, Good, (340)
"The place was walking distance very clean and quiet stuff very friendly a plus including breakfast "
United States
Beatriz
The price is 1.361.656 ₫
1.775.778 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hotel D'Azeglio
Interior entrance
Hotel Bavaria

Hotel Bavaria

Hotel Bavaria
1.0 star property
Sant' Ambrogio
8.2 out of 10, Very good, (408)
"Hermes was very helpful on how to get around the city. He recommended a place to eat. We loved it so much that we went twice. "
United States
Juan
The price is 1.602.539 ₫
1.979.276 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Hotel Bavaria
Property entrance
Residenza D'Epoca Sant'Egidio

Residenza D'Epoca Sant'Egidio

Residenza D'Epoca Sant'Egidio
Sant' Ambrogio
7.2 out of 10, Good, (102)
"It is beautiful! A few stairs to get there but well worth it!!!!! "
United Kingdom
Daniella
The price is 1.589.908 ₫
2.119.507 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Residenza D'Epoca Sant'Egidio
Interior
Wine Apartments Florence Ansonica

Wine Apartments Florence Ansonica

Wine Apartments Florence Ansonica
Sant' Ambrogio
8.6 out of 10, Excellent, (4)
"Pros: Exactly like the pictures. Friendly and responsive staff. Everything works. Washer in apartment. Market nearby. Cons: bed bugs (totally unacceptable!), noisy district, drunks roaming streeets."
Canada
Robert
Wine Apartments Florence Ansonica
Deluxe Villa | Minibar, individually decorated, individually furnished, desk
Villa Tortorelli

Villa Tortorelli

Villa Tortorelli
Sant' Ambrogio
9.6 out of 10, Exceptional, (66)
"Beautiful property! Loved our stay here! "
United States
Olga
Villa Tortorelli
Interior
Mamo Florence - Dante & Virgilio Apartments

Mamo Florence - Dante & Virgilio Apartments

Mamo Florence - Dante & Virgilio Apartments
Sant' Ambrogio
10.0 out of 10, Exceptional, (8)
"Great little 2 bedroom apartment for our family. Very convenient and nice area. "
Australia
Doan
The price is 2.238.248 ₫
5.921.082 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Mamo Florence - Dante & Virgilio Apartments
Bar (on property)
Hotel Villa Liana

Hotel Villa Liana

Hotel Villa Liana
3.0 star property
Sant' Ambrogio
8.6 out of 10, Excellent, (342)
"Within reasonable walking distance of center of town, beautiful room with on site parking."
United States
Terry
Hotel Villa Liana
Garden
Hotel Regency

Hotel Regency

Hotel Regency
5.0 star property
Sant' Ambrogio
9.4 out of 10, Exceptional, (442)
"Amazing stay as always. Beautiful hotel but the staff make it great. Feels like a home away from home. Perfect location that is easily walkable everywhere in the historic center."
United States
Aaron
The price is 7.580.621 ₫
8.832.827 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Hotel Regency
Restaurant
I Quattro Poeti

I Quattro Poeti

I Quattro Poeti
Sant' Ambrogio
8.6 out of 10, Excellent, (158)
"This b&b is fantastic for the right people. To be clear, it is a fourth floor walk up with NO elevator. If this works for you, then the location is great. It’s walking distance to everything and yet not in a main square, so it is quiet at night. It takes some direction following to get in the first time, but everything was very well explained. "
United States
Lori Paige
I Quattro Poeti
Lobby lounge
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
5.0 star property
Sant' Ambrogio
10.0 out of 10, Exceptional, (13)
"This hotel was quite the find! The staff was amazing, attentive, respectful. The amenities, attention to detail, experience was amazing! We will definitely be back."
United States
Nicole
The price is 12.651.594 ₫
14.411.603 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
Presidential Suite, 1 Bedroom, Hot Tub, City View | 1 bedroom, premium bedding, down duvets, desk
Palazzo dei Ciompi Suites

Palazzo dei Ciompi Suites

Palazzo dei Ciompi Suites
Sant' Ambrogio
7.6 out of 10, Good, (392)
"worst customer service and guest support I have had ever experienced "
United States
Eduard
Palazzo dei Ciompi Suites
Interior detail
Alfieri9

Alfieri9

Alfieri9
3.0 star property
Sant' Ambrogio
9.6 out of 10, Exceptional, (158)
"Hotel was in a nice quiet neighborhood, but still only a short walk to main attractions. The breakfast was excellent. Staff interactions were good."
United States
Colin
Alfieri9
City view
Iris Apartments by Mmega

Iris Apartments by Mmega

Iris Apartments by Mmega
Sant' Ambrogio
7.8 out of 10, Good, (12)
"Excellent location bit a bit noisy at night."
United States
Stephen
The price is 2.227.320 ₫
5.295.261 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Iris Apartments by Mmega
Front of property
Florence Central Suites by MMega

Florence Central Suites by MMega

Florence Central Suites by MMega
Sant' Ambrogio
The price is 2.358.338 ₫
5.748.643 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Florence Central Suites by MMega
40-inch flat-screen TV with satellite channels
Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca
Sant' Ambrogio
9.8 out of 10, Exceptional, (56)
"We had an easy check-in. Friendly staff welcomed us and we settled in quickly so we could enjoy the sites. We walked to all tours and restaurants. The restaurant next door was so good, we ate their twice! The property is well located to everything - food, shopping and more!"
United States
Stacey
The price is 2.412.659 ₫
3.024.533 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Dimora del Cardinale - Residenza d'epoca
Apartment | Living area | 24-inch flat-screen TV with digital channels
Mamo Florence - Gilbe One Apartment

Mamo Florence - Gilbe One Apartment

Mamo Florence - Gilbe One Apartment
Sant' Ambrogio
10.0 out of 10, Exceptional, (1)
"El lugar era muy bonito, espacioso y confortable Todo muy limpio y ordenado"
Mexico
Janeth
The price is 2.689.604 ₫
6.726.413 ₫ total
includes taxes & fees
15 Jan - 16 Jan 2026
Mamo Florence - Gilbe One Apartment
Comfort Apartment | Living area
Blue Santa Croce by MMega

Blue Santa Croce by MMega

Blue Santa Croce by MMega
Sant' Ambrogio
The price is 2.620.376 ₫
5.109.098 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Blue Santa Croce by MMega
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Via de' Calzaiuoli and Piazza della Repubblica are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Via de' Calzaiuoli or Giotto's Campanile while you're exploring the neighbourhood.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. The New Florence Opera House is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Sant' Ambrogio Hotel Reviews

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

10/10 Excellent
"Everything was wonderful. If I had a criticism it would be that the breakfast room was too cold. But that would hardly prevent us from visiting again!"
Jade 3-night trip
Posted 13 days ago
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

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Frequently asked questions

What's it like in Sant' Ambrogio?
Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Piazza Massimo D'Azeglio and Mercato di Sant'Ambrogio as part of your Sant' Ambrogio travel plans.
How many hotels can I expect to find in Sant' Ambrogio?
If you're searching for places to stay in Florence, Expedia has something to meet your needs with 515 Sant' Ambrogio hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.
What is there to do around this Florence neighbourhood?
Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Piazza Massimo D'Azeglio and Mercato di Sant'Ambrogio are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Sant' Ambrogio include Jewish Museum, FiesoleBike Day Tours and Galleria d'Arte Civico69. When you're sightseeing in Florence, Teatro della Pergola and Casa Buonarroti are also worth a stop.