What is Santo Spirito like?

Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Porta Romana and Piazza Santo Spirito as part of your Santo Spirito travel plans.

How many hotels can I expect to find in the Santo Spirito area?

Expedia has 466 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.

If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?

Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.

What can I see and do in this Florence neighbourhood?

Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Porta Romana and Piazza Santo Spirito are some other places worth a visit. Uffizi Gallery and Cathedral of Santa Maria del Fiore are some popular places to visit in the area around Santo Spirito. When you're sightseeing in Florence, Piazza del Carmine and Santa Maria della Carmine are also worth a stop.

The Best Hotels in Santo Spirito, Florence - 2025 Updated Prices

Top Trending Hotels Near Santo Spirito, Florence

Premium Double Room, Annex Building (in the garden) | Down duvets, in-room safe, individually decorated, desk

"Had a lovely 3 day stay here with my daughter. Lovely staff and great breakfast . Hope to come again with family in September "

8.729.750 ₫ total

includes taxes & fees

6 Jul - 7 Jul

Junior Suite | Egyptian cotton sheets, premium bedding, memory-foam beds, minibar

"Gulia & Guissepe were so friendly and accommodating during our check in and stay. Great hidden gem as the property asked all to keep silence; great to have a quiet sanctuary away from the hubbub of city life! Nice view from our #5."

Royal Double Room | Minibar, in-room safe, soundproofing, free WiFi

"Great that it was completely separate and quiet - an oasis in a hot and bustling city yet very close to sights, restaurants etc."

7.059.448 ₫ total

includes taxes & fees

9 Jul - 10 Jul

Panoramic Triple Room, 1 Bedroom, Air conditioning, City View | 1 bedroom, hypo-allergenic bedding, minibar, blackout curtains

"My husband and I enjoyed our stay here! Large rooms and bathrooms, wonderful location, and great staff! "

6.392.361 ₫ total

includes taxes & fees

23 Jul - 24 Jul

Comfort Condo, 4 Bedrooms | Private kitchen | Full-sized fridge, microwave, oven, stovetop

"This property accommodated our family of 7 very nicely. We would stay there again if we returned to Florence. There are a few things people should know in booking this property. The location was very nice but it is a 20-25 minute walk to many of the primary attractions of Florence. Also, the adjacent plaza can get quite noisy on the weekends or holidays as people congregate there. The windows/shutters blocked most of the noise in most of the rooms but there were was a room or two where the noise...

"Great location, wonderful staff, awesome room. Will definely stay again! "

3.367.957 ₫ total

includes taxes & fees

27 Jul - 28 Jul

"Good hotel"

Suite | 1 bedroom, down duvets, individually decorated, individually furnished

"Soggiorno Alessandra is a great value! Very close to everything in Florence, and with room for our entire family in one room with a loft space!"

Apartment | Private kitchenette | Fridge, microwave, oven, dishwasher

"Fantastic top floor apartment in medieval building just beyond the Palazzo Pitti on the quieter side of the Arno. There's a cafe and a supermarket nearby, a very popular pizzeria and Santo Spirito 5 minutes away and the heart of the city is just 10 to 15 minutes walk away. The apartment had everything we needed for a family of 5, great cooking facilities and a neat and tidy bathroom. We'd definitely stay there again if we return to Florence. "

7.051.640 ₫ total

includes taxes & fees

18 Jul - 19 Jul

22-inch flat-screen TV with digital channels, TV

"Excellent stay - easy walk to centre - highly recommended"

3.900.677 ₫ total

includes taxes & fees

9 Jul - 10 Jul

"Amazing hotel and Staff! Definitely coming here again during our next trip to Italy!"

16.408.365 ₫ total

includes taxes & fees

6 Jul - 7 Jul

"Beautiful rooms and friendly staff "

7.040.961 ₫ total

includes taxes & fees

20 Jul - 21 Jul

"Very clean (room and shared bath), quiet area in general. Definitely recommend "

Comfort Double Room, Private Bathroom, Courtyard View | Courtyard view

"I loved this place and made me want to go back and stay for a while!!! The host was so nice and accommodating. This is a must book place if you are looking for Florence charm and don’t mind a 20 "

Design Apartment | Private kitchen | Fridge, oven, stovetop, coffee grinder

"Close to train station and most of the places you will be visiting. Checkin was easy and fast. Will definitely stay again!"

5.706.721 ₫ total

includes taxes & fees

7 Jul - 8 Jul

Romantic Apartment, 2 Bedrooms | Living area | Flat-screen TV

"Wonderful place! Spacious and close to everything. The beds were very comfortable. We loved staying here."

"Perfect place, super friendly owners, really helpful. "

"The innkeepers are incredibly helpful, the room was lovely, and in a great location. They helped us celebrate our anniversary! We would stay again and again. "

3.843.958 ₫ total

includes taxes & fees

5 Aug - 6 Aug

"This very hip hotel features a stylish rooftop bar—the hottest spot in the city—along with cool and friendly front desk staff, amazing rooms adorned with antique furniture and beautiful wall paintings, and stunning views throughout."

6.794.265 ₫ total

includes taxes & fees

6 Jul - 7 Jul

"It was average really. Needs to be updated in the rooms blobby area and outside was very nice "

3.652.979 ₫ total

includes taxes & fees

6 Jul - 7 Jul

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.

Historic Centre of Florence

9 out of top 10 points of interest in this area

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

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Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Uffizi Gallery while you're exploring the neighbourhood.

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Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

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