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Our top choices for Santo Spirito hotels

Mamo Florence - Bice & Krizia Apartments

Mamo Florence - Bice & Krizia Apartments
Santo Spirito
8.0 out of 10, Very good, (5 reviews)
"Very nice apartment and great location. The included parking and laundry facilities were the reason we selected the property, and were very happy with everything. Overall a lovely stay. "
United States
Michele
The price is 3.829.757 ₫
7.368.140 ₫ total
includes taxes & fees
7 Jun - 8 Jun
Mamo Florence - Bice & Krizia Apartments

Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (207 reviews)
"The staff was amazing."
United States
Jason
The price is 3.303.054 ₫
4.004.583 ₫ total
includes taxes & fees
10 May - 11 May
Foresteria Valdese di Firenze - Casa per Ferie

La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (179 reviews)
"The room was beautiful and clean, the staff was pleasant, breakfast was fantastic, 10/10"
United States
Dan
The price is 4.806.452 ₫
5.658.321 ₫ total
includes taxes & fees
12 May - 13 May
La Fonderia Firenze

Le Volte by Mmega

Le Volte by Mmega
Santo Spirito
The price is 3.931.604 ₫
7.170.819 ₫ total
includes taxes & fees
21 May - 22 May
Le Volte by Mmega

Drom Florence Rooms & Apartments

Drom Florence Rooms & Apartments
Santo Spirito
9.8 out of 10, Exceptional, (144 reviews)
"Very cute suite with what we thought was a great location in Florence. Away from the hustle and bustle but very walkable to main sites and lots in the close vicinity as well. Claudia was a great host and very responsive. Beds were comfy’ linens and towels were good. We couldn’t use the AC as it was too early in the season. But the apartment cooled off very well at night. A lovely stay!"
Canada
Denise
The price is 5.049.496 ₫
5.925.670 ₫ total
includes taxes & fees
3 Jun - 4 Jun
Drom Florence Rooms & Apartments

L'Antica Porta Boutique B&B

L'Antica Porta Boutique B&B
Santo Spirito
9.0 out of 10, Wonderful, (22 reviews)
"Very goord place to stay"
United States
Victor
The price is 4.145.902 ₫
4.931.716 ₫ total
includes taxes & fees
18 May - 19 May
L'Antica Porta Boutique B&B

Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (170 reviews)
"Great location and extremely charming!"
United States
Brook
The price is 9.058.716 ₫
10.397.683 ₫ total
includes taxes & fees
4 Jun - 5 Jun
Ottantotto Firenze

La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (253 reviews)
"It was in a great location, we had an excellent view from our room."
United States
Tonya
The price is 5.462.877 ₫
6.442.291 ₫ total
includes taxes & fees
17 May - 18 May
La Torre Del Cestello

Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103 reviews)
"Beautiful property and wonderful staff."
United States
Brad
The price is 15.034.718 ₫
16.969.514 ₫ total
includes taxes & fees
10 May - 11 May
Torre di Bellosguardo

1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (184 reviews)
"Huge room on the outskirts of the city centre. Lovely area with great restaurants. The room was exceptionally clean, the downside was the very hard bed as we prefer a softer bed. We would definitely come back here if we returned to Florence."
United Kingdom
Gillian
The price is 3.463.777 ₫
4.181.379 ₫ total
includes taxes & fees
12 May - 13 May
1900 Artevita

Mamo Florence - Casper Apartment

Mamo Florence - Casper Apartment
Santo Spirito
Mamo Florence - Casper Apartment

Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca
Santo Spirito
9.6 out of 10, Exceptional, (51 reviews)
"Excellent place to stay!"
United States
Diane
The price is 6.262.894 ₫
7.260.407 ₫ total
includes taxes & fees
25 May - 26 May
Palazzo D'Oltrarno - Residenza D'Epoca

Cosimo by MMega

Cosimo by MMega
Santo Spirito
9.2 out of 10, Wonderful, (15 reviews)
"Excellent location, wonderful apartment. Happy wife, happy life."
Canada
Robert
The price is 3.361.522 ₫
7.162.435 ₫ total
includes taxes & fees
6 Jun - 7 Jun
Cosimo by MMega

Hotel Firenze 2000

Hotel Firenze 2000
2.0 star property
Santo Spirito
7.2 out of 10, Good, (194 reviews)
"The staff was very nice!"
Canada
Sergiu
The price is 2.599.415 ₫
3.137.774 ₫ total
includes taxes & fees
10 May - 11 May
Hotel Firenze 2000

Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (117 reviews)
"Beautiful boutique hotel, rooms are large and comfortable. The staff are amazing, breakfast is delicious, the location is the best - close to lots of amazing and authentic eating options. Would highly recommend "
United Kingdom
Elizabeth
The price is 10.605.207 ₫
12.098.823 ₫ total
includes taxes & fees
19 May - 20 May
Oltrarno Splendid

AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (228 reviews)
"Gorgeous room in a beautiful property, very helpful staff, tranquil setting"
United Kingdom
Olivia
The price is 12.514.763 ₫
14.199.335 ₫ total
includes taxes & fees
1 Jun - 2 Jun
AdAstra Suites

SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (25 reviews)
"Easy check in and very helpful and polite "
United States
Remi
The price is 10.326.789 ₫
11.730.692 ₫ total
includes taxes & fees
19 May - 20 May
SPIRIT OF FLORENCE Boutique Rooms

Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
9.0 out of 10, Wonderful, (153 reviews)
"Excellent location and very friendly staff."
Canada
Scott
The price is 5.251.982 ₫
6.210.276 ₫ total
includes taxes & fees
11 May - 12 May
Residenza D'Epoca Al Numero 8

Soggiorno Alessandra

Soggiorno Alessandra
Santo Spirito
8.6 out of 10, Excellent, (87 reviews)
"Great location. Away from the central crowds but only a few steps from riverside and short walk to central tourist locations and train stn. Host was awesome. We had a great room (quiet) that included some breakfast items and provided access to shared kitchen. We would stay here again and recommend this to others. "
Canada
Kayedon
The price is 5.036.841 ₫
5.911.749 ₫ total
includes taxes & fees
12 May - 13 May
Soggiorno Alessandra

Palazzo Oliveto

Palazzo Oliveto
Santo Spirito
7.4 out of 10, Good, (97 reviews)
"The room was smaller than we expected, but clean and comfortable. A bit far from the city centre."
Ireland
Anne
The price is 2.806.457 ₫
3.458.326 ₫ total
includes taxes & fees
25 May - 26 May
Palazzo Oliveto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Uffizi Gallery while you're exploring the neighbourhood.

San Giovanni

If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Piazza Santo Spirito and Arno River as part of your Santo Spirito travel plans.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 496 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.
What can I see and do in this Florence neighbourhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Piazza Santo Spirito and Piazza del Carmine are some other places worth a visit. Favourite places to visit in the surrounding area include Piazza di Santa Maria Novella, Uffizi Gallery and Cathedral of Santa Maria del Fiore. When you're sightseeing in Florence, Santa Maria della Carmine and Brancacci Chapel are also worth a stop.