Where to stay in Santo Spirito
Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Historic Centre of Florence
10 out of top 10 points of interest in this area
Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.
Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.
San Giovanni
If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
Santa Croce
Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.
Top hotels in Santo Spirito
Hotel Horto Convento
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
4.456.095 ₫
5.328.769 ₫ total
24 Aug - 25 Aug
includes taxes & fees
9.8/10 Exceptional! (713 reviews)
"Good location, close to main attractions."
Reviewed on 21 Aug 2026
La Torre Del Cestello
Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
2.622.268 ₫
3.311.476 ₫ total
24 Aug - 25 Aug
includes taxes & fees
9.2/10 Wonderful! (295 reviews)
"Lovely residence-style building in a quieter neighborhood that is close to all you need."
Reviewed on 19 Aug 2026
UNA Hotels Vittoria Firenze
Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
2.246.085 ₫
2.897.728 ₫ total
30 Aug - 31 Aug
includes taxes & fees
8.4/10 Very good! (1,005 reviews)
"Very clean, nice rooms, staff and great breakfast / evening food in the restaurant. Location 20min walk to main Santa Maria Station."
Reviewed on 16 Aug 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santo Spirito holiday package cost?
From just . Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favourite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito holiday package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You'll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1null000null000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that's the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It's one of this area's most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Centre Of Florence.
How far in advance should I book my Santo Spirito holiday?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it's totally up to you. Whether you're headed to Santo Spirito with the entire family or enjoying a solo break, there's a bundle to match every budget and style. Once you've made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you're not restricted to hotels. Expedia features all sorts of properties, including holiday rentals like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia holiday package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our holiday packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito holiday package?
If your holiday plans in Santo Spirito have been upended, it's a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.
Stay near popular Santo Spirito attractions
Piazza Santo Spirito
9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art galleries and notable monuments in this vibrant area.
Porta Romana
8.6/10 (29 reviews)
Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the fascinating museums and churches in this vibrant area.
Brancacci Chapel
10.0/10 (1 review)
You can learn about the history of Florence when you stop by Brancacci Chapel. Stroll along the riverfront or visit the notable monuments in this vibrant area.
Santo Spirito Basilica
8.0/10 (3 reviews)
Learn about the local history of Florence when you take a trip to Santo Spirito Basilica. Stroll along the riverfront or visit the notable monuments in this vibrant area.
Piazza del Carmine
10.0/10 (3 reviews)
You can learn about the history of Florence with a trip to Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art galleries.
Santa Maria della Carmine
10.0/10 (1 review)
You can learn about the history of Florence with a visit to Santa Maria della Carmine. Visit the stunning cathedral and notable monuments in this vibrant area.
Church of St Felix
Church of St Felix is just one of the places to see in Florence, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's riverfront or experience its fascinating museums.
Il Nabucco di Matteo Gabellini
You can study the exhibits at Il Nabucco di Matteo Gabellini, a museum with a story of its own, during your travels to Florence. Discover the fascinating museums and stunning cathedral in this vibrant area.