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Search Hotels in South San Mateo, San Francisco

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20 Dec - 21 Dec
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21 Dec - 22 Dec
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26 Dec - 28 Dec
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Our top choices for South San Mateo hotels

Terrace/patio
The Catrina Hotel

The Catrina Hotel

The Catrina Hotel
2.5 star property
South San Mateo
8.2 out of 10, Very good, (938)
"Awesome place my go to"
United States
Virginia
The price is 2.226.249 ₫
2.558.962 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
The Catrina Hotel
Exterior
InterContinental San Francisco by IHG

InterContinental San Francisco by IHG

InterContinental San Francisco by IHG
4.0 star property
28.7 km from South San Mateo
9.2 out of 10, Wonderful, (1027)
"Love this hotel in SF."
United States
JONATHAN
The price is 4.105.140 ₫
5.915.722 ₫ total
includes taxes & fees
24 Dec - 25 Dec
InterContinental San Francisco by IHG
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
30 km from South San Mateo
8.8 out of 10, Excellent, (2814)
"Clean and comfortable room, good staff, great location. "
United Kingdom
David
The price is 2.638.868 ₫
3.105.959 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Club Quarters Hotel in San Francisco
Hypo-allergenic bedding, in-room safe, desk, blackout curtains
Hotel 32One

Hotel 32One

Hotel 32One
3.0 star property
29.6 km from South San Mateo
8.8 out of 10, Excellent, (706)
"Simple, extremely clean and felt very safe in the area. "
United States
Martin
The price is 2.581.501 ₫
3.038.297 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hotel 32One
Lobby
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
30.1 km from South San Mateo
8.6 out of 10, Excellent, (2152)
"Great hotel "
United States
Tanya
The price is 2.943.596 ₫
3.464.466 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Hilton San Francisco Financial District
Courtyard
Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
31.7 km from South San Mateo
8.6 out of 10, Excellent, (2333)
"Great decor and really great location"
United States
Jose
The price is 3.514.631 ₫
5.065.728 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Hotel Zephyr San Francisco
Daily buffet breakfast (USD 22 per person)
citizenM San Francisco Union Square

citizenM San Francisco Union Square

citizenM San Francisco Union Square
4.0 star property
29.2 km from South San Mateo
9.4 out of 10, Exceptional, (1426)
"Great location."
United States
Todd
The price is 2.661.762 ₫
3.132.761 ₫ total
includes taxes & fees
25 Dec - 26 Dec
citizenM San Francisco Union Square
Property entrance
Hotel VIA

Hotel VIA

Hotel VIA
4.0 star property
28.1 km from South San Mateo
9.2 out of 10, Wonderful, (1503)
"Smooth check in and check out. Nice room and friendly staff in a great location "
United States
Nancy
The price is 4.239.347 ₫
4.989.499 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hotel VIA
Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
31.7 km from South San Mateo
9.0 out of 10, Wonderful, (3835)
"Excellent stay and great location! "
United States
CHRISTINE
The price is 3.198.366 ₫
4.972.604 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Caza Fisherman's Wharf
Property entrance
Orchard Garden Hotel

Orchard Garden Hotel

Orchard Garden Hotel
4.0 star property
29.7 km from South San Mateo
9.6 out of 10, Exceptional, (1003)
"Great location "
Canada
Jorge
The price is 3.530.048 ₫
4.213.617 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Orchard Garden Hotel
Lobby sitting area
The Marker Union Square San Francisco

The Marker Union Square San Francisco

The Marker Union Square San Francisco
4.0 star property
29.4 km from South San Mateo
9.0 out of 10, Wonderful, (1110)
"Beautiful hotel with very friendly staff!! Location is also very central, walkable to a lot of restaurants. "
United States
Akila
The price is 3.674.100 ₫
4.324.232 ₫ total
includes taxes & fees
25 Dec - 26 Dec
The Marker Union Square San Francisco
Breakfast and dinner served
Hotel Zelos San Francisco

Hotel Zelos San Francisco

Hotel Zelos San Francisco
4.0 star property
29.1 km from South San Mateo
9.0 out of 10, Wonderful, (1104)
"Clean room, friendly staff, convenient location. "
United States
Elizabeth
The price is 3.599.544 ₫
5.320.770 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hotel Zelos San Francisco
Bar (on property)
Hyatt Centric Fisherman's Wharf San Francisco

Hyatt Centric Fisherman's Wharf San Francisco

Hyatt Centric Fisherman's Wharf San Francisco
4.0 star property
31.6 km from South San Mateo
8.6 out of 10, Excellent, (1470)
"Not so special but nice place to stay "
United States
Claire
The price is 3.474.768 ₫
5.173.915 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Hyatt Centric Fisherman's Wharf San Francisco
Hypo-allergenic bedding, in-room safe, desk, laptop workspace
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG
3.5 star property
30 km from South San Mateo
9.0 out of 10, Wonderful, (5009)
"Rooms were great, staff was great, location was great. "
United States
Jonathan
The price is 3.131.485 ₫
3.685.602 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Golden Gateway by IHG
Lobby
Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel
4.0 star property
29.5 km from South San Mateo
9.2 out of 10, Wonderful, (1812)
"Amazing place"
Australia
David
The price is 3.466.389 ₫
5.163.681 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Beacon Grand, A Union Square Hotel
Suite (Skyline Waterfront Penthouse) | View from room
Harbor Court Hotel

Harbor Court Hotel

Harbor Court Hotel
4.0 star property
29.6 km from South San Mateo
9.0 out of 10, Wonderful, (1001)
"Favorite getaway- great staff, clean rooms very accommodating "
United States
Leticia
The price is 3.658.048 ₫
5.513.519 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Harbor Court Hotel
Indoor pool
Hotel Nikko San Francisco

Hotel Nikko San Francisco

Hotel Nikko San Francisco
4.5 star property
29.2 km from South San Mateo
9.4 out of 10, Exceptional, (2650)
"Clean rooms, great location and welcoming staff"
United Kingdom
Simon
The price is 4.003.827 ₫
5.922.191 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Nikko San Francisco
Lobby lounge
FOUND Hotel, San Francisco

FOUND Hotel, San Francisco

FOUND Hotel, San Francisco
2.0 star property
29.1 km from South San Mateo
8.4 out of 10, Very good, (687)
"Very welcoming, everything was super close by and the room was a perfect size for me."
United States
Anthony
FOUND Hotel, San Francisco
Lobby sitting area
The Andrews Hotel

The Andrews Hotel

The Andrews Hotel
4.0 star property
29.5 km from South San Mateo
8.6 out of 10, Excellent, (1002)
" Charming hotel with a great restaurant."
United States
Robert
The price is 2.125.654 ₫
2.501.789 ₫ total
includes taxes & fees
23 Dec - 24 Dec
The Andrews Hotel
Terrace/patio
White Swan Inn

White Swan Inn

White Swan Inn
3.5 star property
29.7 km from South San Mateo
9.4 out of 10, Exceptional, (1003)
"Great location, friendly staff, and comfortable rooms...great stay!"
United States
LaDonna
White Swan Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in South San Mateo

Find the best South San Mateo areas for the activities you enjoy most.
Union Square featuring a skyscraper and a city

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

Fisherman\'s Wharf featuring a bay or harbour

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

South of Market which includes skyline, a park and cbd

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to San Francisco Bay – discover South of Market, a destination also famous for its shopping.

Nob Hill showing street scenes and a city

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.

Top South San Mateo Hotel Reviews

Mayflower Hotel

Mayflower Hotel

10/10 Excellent
"Good location, blocks from Chinatown. Room was clean. Staff was friendly and very helpful. Breakfast was good. Elevator is vintage. Lobby is beautiful. All in all, very enjoyable. Would definitely recommend and stay again. "
Bell 5-night trip
Posted 4 days ago
Mayflower Hotel

Frequently asked questions

What is South San Mateo like?
Guests are sure to enjoy their time checking out all that San Mateo's South San Mateo neighbourhood has to offer. Make sure that you visit Hillsdale Shopping Center and San Mateo County Event Center as part of your South San Mateo travel plans.
How many hotels will I be able to find in the South San Mateo area?
Expedia has 29 hotels and other accommodation options in South San Mateo to choose from, making this an ideal home base for exploring the greater San Mateo area.
If I need to cancel my hotel reservation in South San Mateo, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in South San Mateo.
What can I see and do in this San Mateo neighbourhood?
Spend some time exploring the great outdoors at Sugarloaf Mountain, Paddock Park and Bay Meadows Park. Hillsdale Shopping Center and San Mateo County Event Center are also a couple of places to visit in the neighbourhood. A few places to visit in the area around South San Mateo include Lakeshore Park Beach, The San Mateo Japanese Garden and Peninsula Museum of Art. While you're out sightseeing, Oceanic Foot Spa and Cinemark Century San Mateo 12 are a couple of additional sights to visit in San Mateo.
How can I get around South San Mateo and the greater San Mateo area?
To venture out of town, take a train from Hillsdale Station.