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Our top choices for Texas Medical Center hotels with a spa

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3593)
"Everything about our stay was excellent. "
United States
Clarence
The price is 3.237.957 ₫
3.788.409 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Blossom Hotel Houston, Curio Collection by Hilton

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1596)
"Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. "
United States
Thomas
The price is 3.562.149 ₫
4.229.244 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hilton Americas-Houston

The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection
4.5 star property
Downtown Houston
9.0 out of 10, Wonderful, (1038)
"The Laura is a great hotel. The amenities, restaurants and bar are top notch. The staff was friendly, helpful and knowledgable about the services offered by the hotel and offered great suggestions for nearby restaurants and entertainment. I enjoyed my stay. No complaints. "
United States
Seleta
The price is 4.085.335 ₫
5.606.705 ₫ total
includes taxes & fees
12 Dec - 13 Dec
The Laura Hotel, Houston Downtown, Autograph Collection

JW Marriott Houston Downtown

JW Marriott Houston Downtown
5.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1006)
"Love the room very kind personal at the check in. "
United States
Antonia
The price is 5.039.458 ₫
6.080.930 ₫ total
includes taxes & fees
19 Dec - 20 Dec
JW Marriott Houston Downtown

Omni Houston Hotel

Omni Houston Hotel
4.0 star property
Greater Uptown
9.0 out of 10, Wonderful, (1002)
"Great location! "
United States
Fletcher
The price is 4.196.246 ₫
4.983.253 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Omni Houston Hotel

Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1008)
"Completely loved our stay at this location. "
United States
Miriam
The price is 4.928.759 ₫
6.495.069 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Marriott Marquis Houston

Hotel ZaZa Houston Memorial City

Hotel ZaZa Houston Memorial City
4.0 star property
Memorial
9.4 out of 10, Exceptional, (1002)
"Beautiful hotel, amazing customer service and it was so comfy. "
United States
Amber
Hotel ZaZa Houston Memorial City

Four Seasons Hotel Houston

Four Seasons Hotel Houston
5.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1002)
"Room was clean"
United States
Kimberly
The price is 12.387.790 ₫
14.625.236 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Four Seasons Hotel Houston

The Post Oak Hotel at Uptown Houston

The Post Oak Hotel at Uptown Houston
5.0 star property
The Galleria
9.6 out of 10, Exceptional, (882)
"Beautiful hotel "
United States
nabintou
The price is 13.890.139 ₫
16.251.462 ₫ total
includes taxes & fees
25 Dec - 26 Dec
The Post Oak Hotel at Uptown Houston

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1843)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Texas Medical Center Hotel Reviews

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Frequently asked questions

Looking to holiday at a spa hotel in Texas Medical Center?
Forget the stress of everyday life and book yourself a lush spa hotel. Enjoy the museums and restaurants in Texas Medical Center—your day trip starts here. Make sure you enjoy the shops during your stay. Spa hotels are a great way to break out of your daily routine and add a layer of luxury to your weekend away.
How many spa hotels are there in Texas Medical Center?
Among Expedia's 181 accommodation options in Texas Medical Center, there is 1 spa hotel.
What's there to see and do in Texas Medical Center?
Enjoy all that Texas Medical Center has to offer when you visit Houston Zoo, NRG Stadium and Toyota Center. If you have extra time while you're in the area, you might want to stop by Houston Natural Science Museum and NRG Astrodome.
What is a Texas Medical Center spa hotel?
Spa hotels in Texas Medical Center have full on-site spas offering services including facials and a range of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your holiday.