Compare and book 5 Star hotels in Texas Medical Center, Houston

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check availability on Texas Medical Center 5 Star Hotels

Tonight
27 Jun - 28 Jun
Tomorrow
28 Jun - 29 Jun
This weekend
27 Jun - 29 Jun
Next weekend
4 Jul - 6 Jul

Top Texas Medical Center 5 Star Hotels

The Post Oak Hotel at Uptown Houston
Outdoor pool, pool cabanas (surcharge), pool umbrellas

The Post Oak Hotel at Uptown Houston

5.0 star property
9.6 out of 10, Exceptional, (760)
"Wonderful classic Hotel, the executive suite was perfect for our stay. "
The price is 14.209.280 ₫
16.624.857 ₫ total
includes taxes & fees
16 Jul - 17 Jul
The Post Oak Hotel at Uptown Houston
JW Marriott Houston Downtown
Meeting facility

JW Marriott Houston Downtown

5.0 star property
9.0 out of 10, Wonderful, (1001)
"Beautiful property, great staff"
The price is 4.785.184 ₫
5.781.766 ₫ total
includes taxes & fees
18 Jul - 19 Jul
JW Marriott Houston Downtown
Four Seasons Hotel Houston
Outdoor pool, pool cabanas (surcharge), pool umbrellas

Four Seasons Hotel Houston

5.0 star property
9.2 out of 10, Wonderful, (1001)
"Great stay"
The price is 11.884.600 ₫
14.034.865 ₫ total
includes taxes & fees
20 Jul - 21 Jul
Four Seasons Hotel Houston
ACP Hotel Houston Westchase, MOD Collection by Sonesta
Reception

ACP Hotel Houston Westchase, MOD Collection by Sonesta

5.0 star property
8.0 out of 10, Very good, (1000)
"Location, clean, and very convenient shopping, variety of food round the area!"
The price is 2.113.695 ₫
2.473.023 ₫ total
includes taxes & fees
9 Jul - 10 Jul
ACP Hotel Houston Westchase, MOD Collection by Sonesta
The St. Regis Houston
Lounge

The St. Regis Houston

5.0 star property
9.2 out of 10, Wonderful, (390)
"Nice place near a venue we attended"
The price is 9.614.772 ₫
11.466.275 ₫ total
includes taxes & fees
13 Jul - 14 Jul
The St. Regis Houston
La Colombe d'Or Hotel
Front of property

La Colombe d'Or Hotel

5.0 star property
9.4 out of 10, Exceptional, (119)
"Amazing stay everything was outstanding"
The price is 10.636.064 ₫
12.443.829 ₫ total
includes taxes & fees
5 Jul - 6 Jul
La Colombe d'Or Hotel
7550 Kirby Dr
Reception

7550 Kirby Dr

5.0 star property
8.2 out of 10, Very good, (43)
"Secured parking and centrally located."
7550 Kirby Dr
TUSCAN VILLA
Front of property

TUSCAN VILLA

5.0 star property
2.0 out of 10, (3)
"Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice. We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer the phone. We couldn’t stay at the property because we had no information on how to get in. We were charged full price and no refund given, I suggest you book somewhere else that has better...
TUSCAN VILLA
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Texas Medical Center.
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

1085 Rusk Street, Houston, TX
The price is 2.664.240 ₫ per night from 1 Jul to 2 Jul
2.664.240 ₫
3.117.161 ₫ total
1 Jul - 2 Jul
includes taxes & fees
8.2/10 Very Good! (3,457 reviews)
Still don't see what you're looking for?
See all properties in Texas Medical Center.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What are the best 5-star hotels in Texas Medical Centre?
Enjoy world-class amenities and superior service at La Colombe d'Or Hotel. Located around the Southwest Houston neighbourhood of Texas Medical Centre, this 5-star hotel is a leading choice based on reviews by our guests.
How much does it cost to stay in a 5-star hotel in Texas Medical Centre?
You can find a range of pricing options for a 5-star hotel in Texas Medical Centre on Expedia. How much you'll pay will depend on your travel dates, trip length and other factors. Compare available accommodation for your desired dates and use our pricing and other filters to find the perfect high-end stay.

  • Search for the lowest price per night from 2.381.622 ₫

What makes a hotel 5 stars in Texas Medical Centre?
In Texas Medical Centre, a hotel is required to offer a specific level of high-end amenities to earn a 5-star rating. These can include gourmet restaurants, on-site gyms, saunas and spas, premium bedding, luxury toiletries and more. What also sets 5-star hotels apart is their exceptional service. You can look forward to things like nightly turn-down services, in-room massages and concierge services. Some may even offer thoughtful touches such as welcome gifts.