Compare and book 5 Star hotels in Texas Medical Center, Houston
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Texas Medical Center 5 Star Hotels
Our top choices for Texas Medical Center 5-star hotels
9.6 out of 10, Exceptional, (882)
"Beautiful hotel "
nabintou
The price is 13.875.383 ₫
16.234.198 ₫ total
includes taxes & fees
30 Dec - 31 Dec
ACP Hotel Houston Westchase, MOD Collection by Sonesta
ACP Hotel Houston Westchase, MOD Collection by SonestaSharpstown
8.0 out of 10, Very good, (1002)
"Clean nice staff’s convenient close to many restaurant markets love it "
johnny
The price is 1.889.823 ₫
2.211.093 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
9.2 out of 10, Wonderful, (1002)
"Room was clean"
Kimberly
The price is 13.164.500 ₫
15.533.847 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
9.0 out of 10, Wonderful, (1000)
"Love the room very kind personal at the check in. "
Antonia
The price is 5.034.105 ₫
6.074.468 ₫ total
includes taxes & fees
19 Dec - 20 Dec
9.2 out of 10, Wonderful, (403)
"Clean room and good service "
JAIME A CHAPA
The price is 9.702.012 ₫
11.570.315 ₫ total
includes taxes & fees
21 Dec - 22 Dec
9.4 out of 10, Exceptional, (145)
"Staff were so friendly & accommodating. Thoroughly enjoyed our stay!"
Elaine
The price is 11.391.242 ₫
13.327.752 ₫ total
includes taxes & fees
22 Dec - 23 Dec
8.2 out of 10, Very good, (45)
"I enjoyed my stay it was worth it"
Yontee
2.0 out of 10, (3)
"Would not recommend . We booked on the same day as check in, no one would answer the phone or let you into the property without 72 hours notice.
We purchased the Villa for one night due to a flight cancellation, tried phoning multiple times and messaging before check in closed but no one would answer the phone.
We couldn’t stay at the property because we had no information on how to get in.
We were charged full price and no refund given, I suggest you book somewhere else that has better...
James
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Texas Medical Center.
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
The price is 3.024.609 ₫ per night from 10 Jan to 11 Jan
3.024.609 ₫
3.563.541 ₫ total
10 Jan - 11 Jan 2026
includes taxes & fees
8.2/10 Very Good! (3,051 reviews)
Still don't see what you're looking for?
See all properties in Texas Medical Center.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Texas Medical Center Hotel Reviews
Frequently asked questions
Explore a world of travel with Expedia
Hotels in Texas Medical Center by Star Rating
Accommodation near Texas Medical Center attractions
- Hotels near MD Anderson Cancer Center
- Hotels near George R. Brown Convention Center
- Hotels near Rice University
- Hotels near Daikin Park
- Hotels near Toyota Center
- Hotels near Houston Zoo
- Hotels near CityCentre
- Hotels near Memorial City Mall
- Hotels near Downtown Aquarium
- Hotels near NRG Park
- Hotels near Smart Financial Centre at Sugar Land
Choose Your Texas Medical Center Hotel Style
- Business Hotels in Texas Medical Center
- Golf Hotels in Texas Medical Center
- Hotels near Museums in Texas Medical Center
- Hotels with Air Conditioning in Texas Medical Center
- Hotels with Babysitting Services in Texas Medical Center
- Hotels with Balcony in Texas Medical Center
- Hotels with Breakfast in Texas Medical Center
- Hotels with Connecting Rooms in Texas Medical Center
- Hotels with Gym in Texas Medical Center
- Hotels with Hot Tubs in Texas Medical Center
- Hotels with Laundry Service in Texas Medical Center
- Hotels with Parking in Texas Medical Center
- Hotels with Pool in Texas Medical Center
- Hotels with Restaurant in Texas Medical Center
- Hotels with Room Service in Texas Medical Center
- Hotels with a Bar in Texas Medical Center
- Hotels with a View in Texas Medical Center
- Shopping Hotels in Texas Medical Center
- Spa Hotels in Texas Medical Center
- Sports Hotels in Texas Medical Center
Recommended cities for you
Explore more hotels
More ways to book
Expedia's Latest Trends
Hotels
General