Eastern Panama Holidays

Book a Hotel + Flight or Car together to unlock savings

Top hotels in Eastern Panama

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande, Isla Grande, Colon
10/10 Exceptional! (2 reviews)
"The Ordovician Hotel is a hidden gem on the peaceful west side of Isla Grande. From the moment we booked, the service was personal and seamless—thank you, Yohan! We were welcomed by name, greeted with a delicious tropical drink, and felt like cherished guests from start to finish. We stayed in the ..."

Reviewed on 25 Jul 2025

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Ordovician Beach Resort
Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale, Cacique, Provincia de Colón
10/10 Exceptional! (9 reviews)
"All was good"

Reviewed on 14 Jul 2025

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Ciel y Miel
Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

2 out of 5
9.542876, -78.899058, Narganá, San Blas
"Communication was good and highly organized. We felt safe and didn’t need to lock up our bags or valuables at all times. Weather was rough (not their fault) so the stay was a challenge with super high winds and rain. The island was covered in trash nearly all the way around. Our cabin doors were ..."

Reviewed on 16 Feb 2022

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Private Over the Water Cabin on San Blas Island
See all 170 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Isla Diablo

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Isla Diablo

Museum of the Kuna Nation

You can spend an afternoon browsing the exhibits at Museum of the Kuna Nation during your travels in Masargantupo. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

Isla Chichime

Frequently asked questions

How much does an Eastern Panama holiday package cost?
The most affordable Eastern Panama holiday package is , so your dream getaway can become a reality — without breaking the bank. Bundle flights, hotels and car rentals to tailor make a package that matches your travelling style.
How do I get a cheap travel package to Eastern Panama?
Lock in flights that suit your schedule, add a hotel to your booking and watch the savings pile up with an Eastern Panama holiday package. It's as simple as that! From flights and hotels to rental cars and activities, Expedia is where your cheap getaway begins. And with over 550 air carriers and 1null000null000 hotels around the world to choose from, you won't be short of choice.
What are the top hotels in Eastern Panama?
For hotels in San Blas Islands with friendly service and cosy beds, look up Private Over The Water Cabin On San Blas Island and San Blas Private Over - The - Water Cabin. If you plan to explore Narganá as well, you can look forward to a great night's sleep at Paradise Over The Water Cabins In San Blas or San Blas Private Over - The - Water Cabin.
How far in advance should I book my Eastern Panama holiday?
Smart travellers often reserve their seats as early as possible. You can generally look up international fares on Expedia up to 12 months before your intended flight. If you're booking last minute, don't despair. Low prices sometimes occur just weeks prior to departure.
What does an Expedia Eastern Panama travel package include?
Flights, rental cars and hotels, or any combination of the three — it's your choice. Whether you're visiting Eastern Panama with the kids or travelling by yourself, there's a package to fit every style and budget. Once you've made your booking, why not add on a couple of tours or activities?
What should I know before booking an Eastern Panama travel package?
Booking all the parts of your getaway together is an excellent way to save. Combine your car rentals, flights and hotels into a neat little package. But it's not just hotels. Expedia features all types of properties, including holiday rentals like mountain cabins and city apartments. Your choices are almost endless!
Can I choose my airline with an Eastern Panama Expedia holiday package?
Yes — that's the beauty of an Expedia holiday package. You're in charge! We have access to more than 550 airline partners across the globe, so you have loads of choice when planning your Eastern Panama getaway.
If I'm not able to travel, can I cancel my Eastern Panama holiday package?
You can. We realise life doesn't always go to plan, so we're happy to help if you have to make changes to your Eastern Panama holiday package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.