
La Mesa Holidays
Book a Hotel + Flight or Car together to unlock savings
Photo by trenton.badillo
Top hotels in La Mesa

Handlery Hotel
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
8/10 Very Good! (1,983 reviews)
"It’s a really good hotel off the beach."
Reviewed on 22 Aug 2025

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 4.010.370 ₫ per night from 1 Sept to 2 Sept
4.010.370 ₫
5.308.774 ₫ total
1 Sept - 2 Sept
includes taxes & fees
8.2/10 Very Good! (5,862 reviews)
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Reviewed on 21 Aug 2025

The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 2.931.010 ₫ per night from 2 Sept to 3 Sept
2.931.010 ₫
3.398.359 ₫ total
2 Sept - 3 Sept
includes taxes & fees
7.8/10 Good! (1,123 reviews)
"Great location and easy to get to. Parking is horrible as the spaces are tiny but other than that, no complaints"
Reviewed on 22 Aug 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Computer Museum of America
You can spend an afternoon browsing the exhibits at Computer Museum of America during your trip to La Mesa. Attend a sporting event while in this walkable area or simply enjoy the top-notch restaurants.