Search Hotels in Otay Mesa West, San Diego

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
13 Dec - 14 Dec
Tomorrow
14 Dec - 15 Dec
Next weekend
19 Dec - 21 Dec
In two weeks
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa West hotels

View from room
The Monsaraz San Diego, Tapestry Collection by Hilton

The Monsaraz San Diego, Tapestry Collection by Hilton

The Monsaraz San Diego, Tapestry Collection by Hilton
3.5 star property
23.1 km from Otay Mesa West
8.6 out of 10, Excellent, (617)
"Great staff, was able to get checked in about an hour early…. Very nice property, lots of seating areas , outdoor patios …. Great Stay"
United States
Jude
The price is 3.346.250 ₫
3.846.347 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Monsaraz San Diego, Tapestry Collection by Hilton
Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
10.5 km from Otay Mesa West
9.2 out of 10, Wonderful, (3522)
"Great friendly staff "
United States
mohammed
The price is 2.817.743 ₫
3.105.012 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Marina Gateway Hotel
American cuisine
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter
3.5 star property
Marina District, 17.8 km from Otay Mesa West
9.0 out of 10, Wonderful, (2698)
"Clean facilities and friendly staff!"
United States
EMMA
The Horton Grand, Downtown/Gaslamp Quarter
Restaurant
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1229)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is 3.606.164 ₫
4.181.166 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3 restaurants, breakfast, lunch, dinner served; Regional cuisine
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
19.2 km from Otay Mesa West
8.4 out of 10, Very good, (6060)
"Always an amazing stay"
United States
Jana
The price is 3.555.391 ₫
4.885.201 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Wyndham San Diego Bayside
Poolside bar
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 17.5 km from Otay Mesa West
9.0 out of 10, Wonderful, (3149)
"Great stay"
United States
Laurence
The price is 4.474.821 ₫
6.397.600 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hard Rock Hotel San Diego
Exterior
Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island
2.5 star property
17.3 km from Otay Mesa West
8.8 out of 10, Excellent, (1001)
"Good to spend a night or two-- nice staff-- friendly ad awesome breakfast"
United States
MICHELE
The price is 4.235.953 ₫
4.659.548 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Suites Hotel Coronado Island
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 17.8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is 2.341.323 ₫
3.474.891 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 18.2 km from Otay Mesa West
9.0 out of 10, Wonderful, (1014)
"Yes everything was great I will stay there again."
United States
Sergio
The price is 3.130.533 ₫
3.560.982 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Gaslamp Plaza Suites
Lobby lounge
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
18.5 km from Otay Mesa West
8.6 out of 10, Excellent, (1449)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
Front of property
The Sofia Hotel

The Sofia Hotel

The Sofia Hotel
3.5 star property
18.5 km from Otay Mesa West
8.4 out of 10, Very good, (1657)
"Great location and history to the hotel "
United States
Stephanie
The Sofia Hotel
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
22.1 km from Otay Mesa West
9.2 out of 10, Wonderful, (3183)
"Great stay and location!"
United States
Jason
The price is 3.291.006 ₫
3.782.684 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Bay Club Hotel & Marina
Lobby
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1162)
"Amenities and location were great. "
United States
Julie
The price is 4.001.295 ₫
5.706.840 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay
3.0 star property
North Pacific Beach, 29.8 km from Otay Mesa West
8.0 out of 10, Very good, (1430)
"Friendly staff, clean room"
United States
Janice
The price is 2.430.767 ₫
2.794.641 ₫ total
includes taxes & fees
15 Dec - 16 Dec
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 17.9 km from Otay Mesa West
9.2 out of 10, Wonderful, (1946)
"Great hotel"
United States
Farzana
The price is 4.182.813 ₫
6.233.247 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Marriott Marquis San Diego Marina
Front of property
Heritage Inn La Mesa

Heritage Inn La Mesa

Heritage Inn La Mesa
2.0 star property
21.9 km from Otay Mesa West
7.0 out of 10, Good, (1204)
"room was clean and staff very friendly"
United States
Charles
The price is 1.497.337 ₫
1.652.332 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Heritage Inn La Mesa
Exterior
La Pensione Hotel

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 19.4 km from Otay Mesa West
8.6 out of 10, Excellent, (1910)
"small room, god location, great for the price"
United States
JAIME
La Pensione Hotel
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
19.1 km from Otay Mesa West
8.8 out of 10, Excellent, (732)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is 2.714.882 ₫
3.147.770 ₫ total
includes taxes & fees
28 Dec - 29 Dec
The DEXTRO Little Italy, BW Premier Collection
Street view
Urban Boutique Hotel

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Little Italy, 19.3 km from Otay Mesa West
8.6 out of 10, Excellent, (1269)
"Locations is excellent and the front desk lady was friendly "
Canada
Ju
Urban Boutique Hotel
Single Room, 1 King Bed, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
7.8 km from Otay Mesa West
7.2 out of 10, Good, (1987)
"Great stay"
United States
Eleazar
The price is 1.685.753 ₫
1.854.381 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hotel Palmeras Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa West Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"Breakfast buffet was good. Room was clean. Friendly and helpful staff. San Diego was beautiful! "
Vito N 3-night trip
Posted 23 hours ago
The DEXTRO Little Italy, BW Premier Collection

Explore a world of travel with Expedia

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.