Photo by Leonardo De Leon

Search Hotels in Otay Mesa West, San Diego

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
13 Sep - 14 Sep
Tomorrow
14 Sep - 15 Sep
Next weekend
19 Sep - 21 Sep
In two weeks
26 Sep - 28 Sep

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Otay Mesa West, San Diego

Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1076)
"Great hotel! "
The price is 3.828.542 ₫
4.218.862 ₫ total
includes taxes & fees
22 Sept - 23 Sept
Ayres Hotel San Diego South - Chula Vista
Best Western San Diego Pacific Beach/Mission Bay
Outdoor pool

Best Western San Diego Pacific Beach/Mission Bay

2.5 star property
7.2 out of 10, Good, (1289)
"Friendly staff!"
The price is 2.186.837 ₫
2.513.660 ₫ total
includes taxes & fees
21 Sept - 22 Sept
Best Western San Diego Pacific Beach/Mission Bay
Sycuan Casino Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1530)
"Great hotel "
Sycuan Casino Resort
SpringHill Suites by Marriott Chula Vista Eastlake
Outdoor pool

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (442)
"Customer service was wonderful for our short stay"
The price is 3.615.567 ₫
3.984.174 ₫ total
includes taxes & fees
21 Sept - 22 Sept
SpringHill Suites by Marriott Chula Vista Eastlake
Best Western Americana Inn
Pillow-top beds, in-room safe, desk, laptop workspace

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1143)
"Breakfast was amazing! "
The price is 3.228.147 ₫
3.672.017 ₫ total
includes taxes & fees
21 Sept - 22 Sept
Best Western Americana Inn
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3279)
"Good place to stay"
The price is 3.539.297 ₫
3.900.128 ₫ total
includes taxes & fees
28 Sept - 29 Sept
Best Western Plus Marina Gateway Hotel
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1406)
"Great stay. "
The price is 2.897.732 ₫
3.187.505 ₫ total
includes taxes & fees
21 Sept - 22 Sept
La Quinta Inn by Wyndham San Diego Chula Vista
Hampton Inn & Suites San Diego Seaworld
Reception

Hampton Inn & Suites San Diego Seaworld

2.5 star property
8.6 out of 10, Excellent, (52)
"Enjoyed our stay."
The price is 3.342.420 ₫
3.841.945 ₫ total
includes taxes & fees
21 Sept - 22 Sept
Hampton Inn & Suites San Diego Seaworld
SureStay Hotel by Best Western San Diego Pacific Beach
Desk, laptop workspace, blackout curtains, iron/ironing board

SureStay Hotel by Best Western San Diego Pacific Beach

2.5 star property
8.0 out of 10, Very good, (1249)
"It was a great stay for us"
The price is 1.671.922 ₫
1.888.353 ₫ total
includes taxes & fees
21 Sept - 22 Sept
SureStay Hotel by Best Western San Diego Pacific Beach
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Free daily buffet breakfast

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

3.0 star property
8.0 out of 10, Very good, (1360)
"Great location. "
The price is 2.299.184 ₫
2.643.359 ₫ total
includes taxes & fees
30 Sept - 1 Oct
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Best Western Yacht Harbor Hotel
Desk, blackout curtains, iron/ironing board, cots/infant beds

Best Western Yacht Harbor Hotel

2.5 star property
8.6 out of 10, Excellent, (1530)
"The staff were very helpful and friendly telling us about the local area "
The price is 2.874.244 ₫
3.298.194 ₫ total
includes taxes & fees
12 Oct - 13 Oct
Best Western Yacht Harbor Hotel
Pleasant Inn
Desk, laptop workspace, blackout curtains, iron/ironing board

Pleasant Inn

2.5 star property
8.4 out of 10, Very good, (1150)
"Quick check in and friendly staff."
The price is 2.467.558 ₫
2.831.523 ₫ total
includes taxes & fees
28 Sept - 29 Sept
Pleasant Inn
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1493)
"Great hotel"
The price is 2.893.773 ₫
3.183.150 ₫ total
includes taxes & fees
21 Sept - 22 Sept
Best Western Chula Vista/Otay Valley Hotel
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very good, (1005)
"Great location!"
The price is 2.617.987 ₫
2.879.786 ₫ total
includes taxes & fees
28 Sept - 29 Sept
Best Western Plus La Mesa San Diego
Hotel Palmeras Chula Vista
Front of property

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1857)
"Great stay"
The price is 2.008.091 ₫
2.208.927 ₫ total
includes taxes & fees
15 Sept - 16 Sept
Hotel Palmeras Chula Vista
Hercor Hotel - Urban Boutique
Deluxe Room, 1 King Bed | Premium bedding, down duvets, pillow-top beds, in-room safe

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1247)
"We enjoyed our stay and staff was fantastic "
The price is 2.695.116 ₫
2.969.882 ₫ total
includes taxes & fees
12 Oct - 13 Oct
Hercor Hotel - Urban Boutique
Lamplighter Inn & Suites at SDSU
Outdoor pool, pool umbrellas, pool loungers

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1247)
"Family friendly, great pool, great breakfast, staff is fantastic. "
Lamplighter Inn & Suites at SDSU
Valli Hi Motel
Desk, blackout curtains, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very good, (1004)
"Great hotel "
Valli Hi Motel
Super 8 by Wyndham El Cajon/San Diego
Lobby

Super 8 by Wyndham El Cajon/San Diego

2.0 star property
7.8 out of 10, Good, (1001)
"Great place "
The price is 2.063.776 ₫
2.274.178 ₫ total
includes taxes & fees
22 Sept - 23 Sept
Super 8 by Wyndham El Cajon/San Diego
Quality Inn San Diego South - Chula Vista
Coffee service

Quality Inn San Diego South - Chula Vista

2.5 star property
7.6 out of 10, Good, (1002)
"Friendly staff and super clean rooms."
The price is 2.374.398 ₫
2.611.838 ₫ total
includes taxes & fees
22 Sept - 23 Sept
Quality Inn San Diego South - Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa West Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is Otay Mesa West like?

Otay Mesa West is a neighbourhood that travellers like for its cathedral.

If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?

Yes! The majority of room reservations are refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.

What is there to do around this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.

How can I get around Otay Mesa West and the greater San Diego area?

Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.