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17 Dec - 18 Dec
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18 Dec - 19 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Penrose hotels

Lobby
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis, 7.3 km from Penrose
8.4 out of 10, Very good, (4017)
"Everything was great!"
United States
Kathryn
The price is 2.214.155 ₫
2.611.130 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Hyatt Regency St. Louis at The Arch
Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis, 6.7 km from Penrose
8.8 out of 10, Excellent, (1155)
"Really nice hotel!"
United States
DARIN
The price is 2.297.038 ₫
2.731.844 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Property amenity
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis, 7.3 km from Penrose
9.4 out of 10, Exceptional, (3285)
"Our stay was very enjoyable. Location was great and kids loved the indoor pool!"
United States
Christy
The price is 3.551.857 ₫
4.153.151 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Drury Plaza Hotel St. Louis at the Arch
Standard King Room with Whirlpool - Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis
3.0 star property
26.7 km from Penrose
7.4 out of 10, Good, (1004)
"Bed was comfortable, room was quiet, breakfast had limited options and bathroom was tiny. Overall great value for the price! "
United States
Alison
The price is 1.206.326 ₫
1.387.034 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Quality Inn O'Fallon IL - St. Louis
Free daily buffet breakfast
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown
2.5 star property
Downtown West, 6.3 km from Penrose
7.6 out of 10, Good, (592)
"Breakfast was delicious and room was comfy "
United States
Ronnesha
The price is 2.136.008 ₫
2.497.614 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Tru By Hilton St. Louis Downtown
Breakfast, dinner and brunch served
The Principal Hotel

The Principal Hotel

The Principal Hotel
3.5 star property
26.5 km from Penrose
9.8 out of 10, Exceptional, (191)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is 2.968.257 ₫
3.294.263 ₫ total
includes taxes & fees
23 Dec - 24 Dec
The Principal Hotel
Indoor pool
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
30.5 km from Penrose
8.0 out of 10, Very good, (1010)
"Great staff, clean room. "
United States
Amanda
The price is 2.351.767 ₫
2.702.816 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn St. Charles St. Peters
Exterior
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis, 6.7 km from Penrose
8.8 out of 10, Excellent, (1244)
"Great hospitality"
United States
Alejandro
The price is 2.891.163 ₫
3.438.431 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Embassy Suites by Hilton St. Louis Downtown
Exterior
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
9.1 km from Penrose
8.8 out of 10, Excellent, (3034)
"Clean room, good breakfast and good location "
United States
Martin
The price is 2.390.791 ₫
2.791.144 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Clayton Plaza Hotel & Extended Stay
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
13.3 km from Penrose
9.4 out of 10, Exceptional, (2745)
"Friendly staff.. airport shuttle service excellent!!"
United States
Nancy and Ron
The price is 2.367.817 ₫
2.787.493 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Pear Tree Inn St. Louis Airport
5 restaurants, breakfast, lunch, dinner served; American cuisine
River City Casino & Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
16.6 km from Penrose
9.0 out of 10, Wonderful, (1449)
"Awesome place to stay!!"
United States
Kaitlyn
The price is 2.604.625 ₫
3.414.509 ₫ total
includes taxes & fees
23 Dec - 24 Dec
River City Casino & Hotel
Front of property
Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch
4.0 star property
Downtown St. Louis, 7.1 km from Penrose
8.8 out of 10, Excellent, (1018)
"My second time staying there as always it was lovely "
United States
Nina
The price is 2.715.398 ₫
3.202.242 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Hilton Pennywell St. Louis at the Arch
Lobby
Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO
2.0 star property
16.7 km from Penrose
8.4 out of 10, Very good, (1618)
"great stay."
United States
Allison
The price is 1.504.783 ₫
1.839.472 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Motel 6 Hazelwood, MO
Exterior
Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG
2.5 star property
28.9 km from Penrose
9.4 out of 10, Exceptional, (703)
"Great breakfast ! "
United States
Jeanette
The price is 2.449.527 ₫
2.718.484 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Troy by IHG
Lobby sitting area
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
21.1 km from Penrose
7.4 out of 10, Good, (1003)
"Clean lobby, super friendly staff, effortless check in. There’s even a small market with food and essentials right next to the check in desk. "
United States
Jen
The price is 1.875.519 ₫
2.175.377 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Exterior
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center
3.0 star property
Downtown St. Louis, 6.6 km from Penrose
9.0 out of 10, Wonderful, (1010)
"Was a great stay. "
United States
Lorilyn
The price is 2.661.459 ₫
3.165.245 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Courtyard by Marriott St. Louis Downtown/Convention Center
Indoor pool, open 6:00 AM to 10:00 PM, pool loungers
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 star property
Downtown St. Louis, 7 km from Penrose
8.6 out of 10, Excellent, (1174)
"Breakfast was great and this was my seventh year staying there."
United States
Derick
The price is 2.567.525 ₫
3.002.182 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Exterior
Best Western Plus St. Louis Airport Hotel

Best Western Plus St. Louis Airport Hotel

Best Western Plus St. Louis Airport Hotel
2.5 star property
12 km from Penrose
9.2 out of 10, Wonderful, (1002)
"Room was nice and comfortable, pool was awesome, and breakfast left us all happy"
United States
Letez
Best Western Plus St. Louis Airport Hotel
Property amenity
Moonrise Hotel

Moonrise Hotel

Moonrise Hotel
4.0 star property
5.8 km from Penrose
9.0 out of 10, Wonderful, (1918)
"Clean rooms, good coffee and fresh muffins and friendly service."
United States
Colleen
The price is 3.033.713 ₫
3.607.964 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Moonrise Hotel
Lobby
Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
18.3 km from Penrose
8.0 out of 10, Very good, (1033)
"The room was great and the bed was very comfortable "
United States
Joyce
The price is 2.214.155 ₫
2.568.153 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Best Western Plus St. Louis West-Westport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Penrose

Find the best Penrose areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Central West End

Central West End

If you're looking for things to see and do in Central West End, ample dining options and lush forests are highlights. You might also check out World Chess Hall of Fame while you're visiting, and jump aboard the metro at Central West End Station to get around town.

Top Penrose Hotel Reviews

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Frequently asked questions

What's it like in Penrose?
Travellers are sure to enjoy a stay in St. Louis's Penrose neighbourhood. Consider a visit to Julia Davis Branch Library as part of your Penrose travel plans.
If I need to cancel my hotel reservation in Penrose, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then filter by "fully refundable" to get top deals in Penrose.
What is there to do around this St. Louis neighbourhood?
Julia Davis Branch Library is an attraction you might want to check out while you're in Penrose. Shelley House and Bellefontaine Cemetery are also worth a visit when you're out sightseeing in St. Louis.