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23 Dec - 24 Dec
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24 Dec - 25 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Sikeston Depot Museum hotels

Property amenity
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
2.4 km from Sikeston Depot Museum
9.2 out of 10, Wonderful, (41)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is 2.657.815 ₫
3.009.311 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Fairfield Inn & Suites by Marriott Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
2.2 km from Sikeston Depot Museum
9.0 out of 10, Wonderful, (449)
"Friendly staff clean rooms "
United States
Christopher
The price is 2.567.818 ₫
2.907.413 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Sikeston
Property amenity
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
2.4 km from Sikeston Depot Museum
9.0 out of 10, Wonderful, (8)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is 3.105.170 ₫
3.515.828 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
TownePlace Suites by Marriott Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
2.1 km from Sikeston Depot Museum
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is 2.447.295 ₫
2.770.949 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Indoor pool, outdoor pool
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
5 km from Sikeston Depot Museum
9.4 out of 10, Exceptional, (1002)
"Everything was clean, staff was friendly "
United States
Matthew
The price is 1.973.362 ₫
2.268.616 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Pear Tree Inn Sikeston
Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
5.1 km from Sikeston Depot Museum
9.4 out of 10, Exceptional, (1009)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is 2.368.087 ₫
2.722.550 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Drury Inn & Suites Sikeston, MO
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
4.9 km from Sikeston Depot Museum
8.4 out of 10, Very good, (282)
"Room was clean, breakfast was very good. "
United States
Connie
The price is 2.326.246 ₫
2.651.340 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Comfort Inn & Suites Sikeston I-55
Individually decorated, individually furnished, desk, blackout curtains
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
5 km from Sikeston Depot Museum
8.4 out of 10, Very good, (722)
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is 1.460.219 ₫
1.664.285 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
5.4 km from Sikeston Depot Museum
8.4 out of 10, Very good, (1007)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is 1.990.467 ₫
2.268.635 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Best Western Plus Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
4.7 km from Sikeston Depot Museum
6.8 out of 10, (568)
"Awesomeness "
United States
Rick
The price is 1.563.111 ₫
1.781.789 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Sikeston/Miner Area
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
5.5 km from Sikeston Depot Museum
6.8 out of 10, (120)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is 1.406.274 ₫
1.673.115 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Country Yard Inn and Suite
1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
5.4 km from Sikeston Depot Museum
7.2 out of 10, Good, (1002)
"A great stay in every aspect. "
United States
Gertrude
The price is 1.655.214 ₫
1.886.529 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Days Inn and Suites by Wyndham Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Depot Museum Hotel Reviews

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent
"Staff"
April 1-night trip
Posted 2 weeks ago
Fairfield Inn & Suites by Marriott Sikeston
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

10/10 Excellent
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
Jason 3-night trip
Posted 1 month ago
TownePlace Suites by Marriott Sikeston

Hotels near other Sikeston Depot Museum attractions

Central Park

3.8/5 (36 reviews)
Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savour the top-notch restaurants.
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City of Miner Convention Center

Learn about the events happening in City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savour the top-notch restaurants.
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Frequently asked questions

What's the area like around Sikeston Depot Museum?
Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. You'll find 15 hotels and other accommodations within a few miles for a convenient home base.
How many hotels will I find close to Sikeston Depot Museum?
Expedia has 15 hotels and other accommodation options a few miles from Sikeston Depot Museum.
If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and get a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best options available near Sikeston Depot Museum.