Compare and book 5 Star hotels in Santa Clara, Panama City

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Santa Clara 5 Star Hotels

This weekend
Next weekend

Top Santa Clara 5 Star Hotels

Our top choices for Santa Clara 5-star hotels

Hotel Riu Plaza Panama

5.0 star property
9.0 out of 10, Wonderful, (4215)
"Very convenient location, friendly staff and all around beautiful hotel."
The price is 2.658.440 ₫
2.924.284 ₫ total
includes taxes & fees
30 Aug - 31 Aug
Hotel Riu Plaza Panama

JW Marriott Panama

5.0 star property
8.8 out of 10, Excellent, (1005)
"Always an exceptional stay. "
The price is 6.700.919 ₫
7.371.011 ₫ total
includes taxes & fees
6 Sept - 7 Sept
JW Marriott Panama

The Westin Playa Bonita Panama

5.0 star property
8.0 out of 10, Very good, (1007)
"Excelente hotel. "
The price is 4.151.125 ₫
4.566.237 ₫ total
includes taxes & fees
6 Sept - 7 Sept
The Westin Playa Bonita Panama

Waldorf Astoria Panama

5.0 star property
9.0 out of 10, Wonderful, (1004)
"Great hotel for my recent stay in Panam "
The price is 5.801.613 ₫
6.381.774 ₫ total
includes taxes & fees
20 Sept - 21 Sept
Waldorf Astoria Panama

Sofitel Legend Casco Viejo, Panama City

5.0 star property
9.8 out of 10, Exceptional, (496)
"Very impressive hotel and surrounding area."
The price is 7.708.253 ₫
8.479.078 ₫ total
includes taxes & fees
3 Sept - 4 Sept
Sofitel Legend Casco Viejo, Panama City

W Panama

5.0 star property
8.8 out of 10, Excellent, (1008)
"Great hotel "
The price is 5.460.342 ₫
6.006.377 ₫ total
includes taxes & fees
14 Sept - 15 Sept
W Panama

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
9.6 out of 10, Exceptional, (599)
"The staff was very friendly. "
The price is 5.812.945 ₫
6.394.239 ₫ total
includes taxes & fees
20 Sept - 21 Sept
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Renaissance Panama City Hotel

5.0 star property
8.8 out of 10, Excellent, (49)
"Staff very friendly and accommodating. We extended our stay at this hotel because of the property and the staff. "
The price is 2.714.359 ₫
2.985.795 ₫ total
includes taxes & fees
12 Sept - 13 Sept
Renaissance Panama City Hotel

Hilton Panama

5.0 star property
8.8 out of 10, Excellent, (1003)
"The food was very good at the hotel. Several options to choose from at the hotel. "
The price is 5.577.612 ₫
6.135.373 ₫ total
includes taxes & fees
20 Sept - 21 Sept
Hilton Panama

Bristol Panama, a Registry Collection Hotel

5.0 star property
9.2 out of 10, Wonderful, (1000)
"A lovely hotel and excellent food and rooms and service. "
The price is 5.277.188 ₫
5.805.039 ₫ total
includes taxes & fees
26 Sept - 27 Sept
Bristol Panama, a Registry Collection Hotel

Megapolis Hotel Panamá

5.0 star property
8.4 out of 10, Very good, (1001)
"This is THE place to stay in Panama City... it's location, friendly accommodating staff, and the amenities are fantastic. The rooms were wonderful, clean and bright. We tried Tauro (steakhouse) and the Bazaar - they were both delicious and the service excellent. We literally partied like rock stars at their rooftop restaurant, and at the wonderful outdoor infinity pool as well. We will definitely be returning! "
Megapolis Hotel Panamá

Waymore Hotel Spa and Casino

5.0 star property
6.2 out of 10, (1000)
"Clean and safe. Lot of security."
Waymore Hotel Spa and Casino
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Clara.
Still don't see what you're looking for?
See all properties in Santa Clara.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Santa Clara Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Santa Clara?
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City is a leading option around the Panama City neighbourhood of Santa Clara according to Expedia customer reviews. From its world-class services to its top-of-the-line amenities, this 5-star hotel promises a luxurious and comfortable stay.
How much does it cost to stay in a 5-star hotel in Santa Clara?
How much you pay for a 5-star hotel in Santa Clara can vary according to when you want to travel and how long you plan to be away, among a number of factors. Use our price per night filter and other search tools to find the best deal on a high-end stay.

  • Search for the lowest price per night from 2.134.329 ₫

What makes a hotel 5 stars in Santa Clara?
Exemplary guest service is integral to every 5-star hotel in Santa Clara. From the moment you arrive, staff attend to your every whim, whether recommending activities and tours or providing in-room massage treatments. Also, hotels must feature superior conveniences to be eligible for a 5-star rating. These can include luxury bathrobes, saunas or spas, pools, gourmet kitchens and knowledgeable concierge.