Boat Ride on Lake Hartwell

Search Hotels in Downtown, Seneca

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Downtown hotels

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (713 reviews)
"Clean room comfortable beds"
United States
Cheryl
The price is 2.224.511 ₫
2.612.584 ₫ total
includes taxes & fees
21 Jun - 22 Jun
Quality Inn Seneca Clemson Area US-123

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
2 km from Downtown
9.4 out of 10, Exceptional, (235 reviews)
"Excellent in every way … staff, room, amenities and very comfortable bed!"
United States
Sarah
The price is 3.393.990 ₫
3.733.390 ₫ total
includes taxes & fees
18 Jun - 19 Jun
Fairfield Inn & Suites Seneca Clemson Univ Area

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
15.2 km from Downtown
9.8 out of 10, Exceptional, (863 reviews)
"Terrific place to stay and the staff was very helpful too."
United States
Anne
The price is 3.920.190 ₫
4.351.412 ₫ total
includes taxes & fees
15 Jun - 16 Jun
The Inn at Patrick Square

Hampton Inn & Suites Lavonia

Hampton Inn & Suites Lavonia
2.5 star property
30.7 km from Downtown
9.0 out of 10, Wonderful, (408 reviews)
"The breakfast was great, the staff was very friendly and the hotel very clean. We highly recommend."
United States
Russell
The price is 3.565.531 ₫
4.231.911 ₫ total
includes taxes & fees
20 Jun - 21 Jun
Hampton Inn & Suites Lavonia

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
2.5 star property
25 km from Downtown
9.2 out of 10, Wonderful, (624 reviews)
"Room was clean and customer service was excellent, check in was smooth "
United States
Gina
The price is 2.894.100 ₫
3.212.451 ₫ total
includes taxes & fees
20 Jun - 21 Jun
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
11.8 km from Downtown
8.2 out of 10, Very good, (1,005 reviews)
"We always stay here when in Clemson. It's convenient and the breakfast and restaurant are great."
United States
Greg
The price is 2.504.712 ₫
2.779.915 ₫ total
includes taxes & fees
17 Jun - 18 Jun
Best Western Plus Clemson Hotel & Conference Center

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
11.7 km from Downtown
8.4 out of 10, Very good, (1,005 reviews)
"Great breakfast and friendly staff made our stay enjoyable."
United States
Lon
The price is 2.817.801 ₫
3.127.759 ₫ total
includes taxes & fees
30 Jun - 1 Jul
Comfort Inn & Suites Clemson - University Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
3.1 km from Downtown
6.8 out of 10, (753 reviews)
"Clean and comfortable "
United States
Robyn
The price is 1.967.988 ₫
2.164.788 ₫ total
includes taxes & fees
18 Jun - 19 Jun
Days Inn by Wyndham Seneca / Clemson Area

Hilton Garden Inn Anderson

Hilton Garden Inn Anderson
3.0 star property
25.7 km from Downtown
9.0 out of 10, Wonderful, (734 reviews)
"Great place to stay"
United States
Maureen
The price is 2.613.372 ₫
2.900.841 ₫ total
includes taxes & fees
20 Jun - 21 Jun
Hilton Garden Inn Anderson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
8.6 km from Downtown
9.0 out of 10, Wonderful, (1,014 reviews)
"I enjoyed my stay and all the amenities were excellent! I can’t wait to return!"
United States
Renata
The price is 2.867.790 ₫
3.560.006 ₫ total
includes taxes & fees
16 Jun - 17 Jun
Lakeside Lodge Clemson

Budget Inn Express

Budget Inn Express
2.0 star property
19.9 km from Downtown
5.8 out of 10, (252 reviews)
"Facilities and entertainment surround the Hotel in short trips!"
United States
Stephen
The price is 1.736.460 ₫
1.927.471 ₫ total
includes taxes & fees
15 Jun - 16 Jun
Budget Inn Express

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
10.3 km from Downtown
9.4 out of 10, Exceptional, (1,005 reviews)
"This was such a great hotel! The staff were so nice and friendly, the hotel and room were clean and comfy. I would definitely stay again and recommend to others. "
United States
Melissa
The price is 3.657.090 ₫
4.059.370 ₫ total
includes taxes & fees
1 Jul - 2 Jul
Clemson University's James F. Martin Inn

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
10.1 km from Downtown
9.6 out of 10, Exceptional, (611 reviews)
"Great location - wonderful hotel!"
United States
Samuel
The price is 3.528.171 ₫
3.916.270 ₫ total
includes taxes & fees
1 Jul - 2 Jul
The Abernathy of Clemson

Hampton Inn Anderson

Hampton Inn Anderson
2.5 star property
25 km from Downtown
8.8 out of 10, Excellent, (419 reviews)
"The room did have a funny smell at first, but overall it was clean. The two ladies at the desk was AMAZING. Definitely will book again"
United States
Bernadette
The price is 2.986.711 ₫
3.315.250 ₫ total
includes taxes & fees
21 Jun - 22 Jun
Hampton Inn Anderson

Quality Inn Clemson near University

Quality Inn Clemson near University
2.5 star property
29.6 km from Downtown
7.0 out of 10, Good, (940 reviews)
"Clean room,ac in the middle of a decent size town, overall good hotel"
United States
Roberto
The price is 1.499.407 ₫
1.664.341 ₫ total
includes taxes & fees
5 Jul - 6 Jul
Quality Inn Clemson near University

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
1.7 km from Downtown
8.4 out of 10, Very good, (665 reviews)
"Friendly staff, comfortable bed"
United States
Michelle
The price is 2.549.702 ₫
2.804.671 ₫ total
includes taxes & fees
16 Jun - 17 Jun
Best Western Seneca-Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
10.6 km from Downtown
9.8 out of 10, Exceptional, (816 reviews)
"Great place to stay"
United States
Amy
The price is 4.001.751 ₫
4.441.917 ₫ total
includes taxes & fees
16 Jun - 17 Jun
The Shepherd Hotel Downtown Clemson

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson
2.0 star property
25.6 km from Downtown
8.0 out of 10, Very good, (1,017 reviews)
"Everything about the place was great"
United States
Eli
The price is 1.610.172 ₫
1.787.291 ₫ total
includes taxes & fees
29 Jun - 30 Jun
Days Inn by Wyndham Anderson

Holiday Inn Express Hotel & Suites Lavonia by IHG

Holiday Inn Express Hotel & Suites Lavonia by IHG
2.5 star property
30.7 km from Downtown
8.8 out of 10, Excellent, (421 reviews)
"Very friendly staff. Room was clean and breakfast was good!"
United States
Rebecca
The price is 3.341.370 ₫
3.974.125 ₫ total
includes taxes & fees
28 Jun - 29 Jun
Holiday Inn Express Hotel & Suites Lavonia by IHG

Country Inn & Suites by Radisson, Anderson, SC

Country Inn & Suites by Radisson, Anderson, SC
2.5 star property
25.2 km from Downtown
8.4 out of 10, Very good, (1,009 reviews)
"Room was very clean and the staff super friendly. Kids got to use the pool and great breakfast before checking out. Wonderful stay!"
United States
Makayla
The price is 2.817.801 ₫
3.127.759 ₫ total
includes taxes & fees
21 Jun - 22 Jun
Country Inn & Suites by Radisson, Anderson, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown

Find the best Downtown areas for the activities you enjoy most.

Serenity Bay

When in Serenity Bay, you can plan a visit to Keowee Key Golf Course and Lake Keowee, some noteworthy sights in the nearby area.

Pine Ridge Point

If you're looking for some top things to see and do in Pine Ridge Point and surrounding area, you can visit Lake Keowee and Keowee Key Golf Course.

Indian Oaks

While Indian Oaks may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like The Gauntlet and Seneca Historic District.

Keowee Plantation

While Keowee Plantation isn't home to many top sights, The Gauntlet and Seneca Historic District are some notable places to visit nearby.

Top Downtown Hotel Reviews

Frequently asked questions

What is Downtown like?
Travellers to the Downtown neighbourhood in Seneca will be sure to enjoy their stay. Make sure that you visit The Gauntlet and Seneca Historic District as part of your Downtown travel plans.
How many hotels will I be able to find in Downtown?
If you're searching for places to stay in Seneca, choose from one of Expedia's 13 hotels and other accommodation options in Downtown.
If I need to cancel my hotel reservation in Downtown, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals in Downtown.
What can I see and do in this Seneca neighbourhood?
The Gauntlet, Seneca Historic District and Blue Ridge Arts Center are just a few attractions to check out in Downtown. As you're discovering the neighbourhood, Bertha Lee Strickland Cultural Museum and Oconee County Library Seneca Branch are some other places worth a visit. Seneca City Hall, Golden Corner Plaza and Oconee Community Theatre are just a few of the places to visit in and around Downtown. While you're out sightseeing in Seneca, make sure that you visit other sights such as Applewood Shopping Center or Wyndham Plaza.

Explore a world of travel with Expedia