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10 Dec - 11 Dec
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11 Dec - 12 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for East Seneca hotels

Suite, 1 King Bed with Sofa bed, Non Smoking | Desk, blackout curtains, iron/ironing board, free cots/infant beds
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport
2.5 star property
11.4 km from East Seneca
8.0 out of 10, Very good, (1886)
"Clean facility, friendly staff, convenient location, overall nice stay."
Canada
Kris
The price is 1.885.251 ₫
2.144.472 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Sleep Inn & Suites Buffalo Airport
Reception hall
M Hotel Buffalo

M Hotel Buffalo

M Hotel Buffalo
3.5 star property
9.2 km from East Seneca
7.4 out of 10, Good, (2522)
"Clean rooms, good breakfast, check in process was quick."
United States
Chris
The price is 2.348.409 ₫
2.671.282 ₫ total
includes taxes & fees
17 Dec - 18 Dec
M Hotel Buffalo
2 restaurants, dinner served
The Delavan Hotel & Spa

The Delavan Hotel & Spa

The Delavan Hotel & Spa
4.0 star property
11.4 km from East Seneca
8.8 out of 10, Excellent, (1001)
"Great location. Very spacious hotel, including the bathrooms. Friendly staff. Fun place to stay. "
United States
Michael
The Delavan Hotel & Spa
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG

Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG

Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG
2.5 star property
10.6 km from East Seneca
8.2 out of 10, Very good, (1004)
"It was a short, but nice stay."
United States
Sheila
The price is 2.188.710 ₫
2.489.657 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG
Lunch and dinner served, American cuisine
Buffalo Airport Hotel

Buffalo Airport Hotel

Buffalo Airport Hotel
3.0 star property
11.2 km from East Seneca
8.0 out of 10, Very good, (2764)
"Nice place to stay in "
United States
Dey
The price is 1.735.872 ₫
1.974.554 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Buffalo Airport Hotel
Reception
Garden Place Hotel

Garden Place Hotel

Garden Place Hotel
3.5 star property
12.6 km from East Seneca
7.8 out of 10, Good, (2134)
"A lovely hotel close to the airport. "
United States
Jasmine
Garden Place Hotel
Free daily continental breakfast
Quality Inn Near Walden Galleria Mall

Quality Inn Near Walden Galleria Mall

Quality Inn Near Walden Galleria Mall
2.5 star property
8.4 km from East Seneca
8.0 out of 10, Very good, (1018)
"Friendly staff, easy parking"
United States
Brittany
The price is 2.217.678 ₫
2.522.608 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Quality Inn Near Walden Galleria Mall
Lobby
La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport
3.0 star property
12.7 km from East Seneca
8.0 out of 10, Very good, (1346)
"Rooms were clean… staff was nice… breakfast was good…. Dinner at the anchor bar right next store almost in the same parking lot "
Canada
Chad
The price is 1.950.062 ₫
2.218.196 ₫ total
includes taxes & fees
23 Dec - 24 Dec
La Quinta Inn by Wyndham Buffalo Airport
Free self-parking
Hyatt Place Buffalo/Amherst

Hyatt Place Buffalo/Amherst

Hyatt Place Buffalo/Amherst
3.0 star property
14.7 km from East Seneca
9.0 out of 10, Wonderful, (1097)
"Only place I stay. Always a great experience and clean rooms!"
United States
Linda
The price is 4.012.195 ₫
4.563.872 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Hyatt Place Buffalo/Amherst
Serves dinner and happy hour
Aloft Buffalo Airport

Aloft Buffalo Airport

Aloft Buffalo Airport
3.0 star property
10.7 km from East Seneca
8.0 out of 10, Very good, (1001)
"Excellent, friendly staff!"
United States
Matthew
The price is 2.380.037 ₫
2.799.542 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Aloft Buffalo Airport
Standard Room, 2 Queen Beds, Non Smoking | Premium bedding, desk, laptop workspace, blackout curtains
Days Inn by Wyndham Tonawanda/Buffalo

Days Inn by Wyndham Tonawanda/Buffalo

Days Inn by Wyndham Tonawanda/Buffalo
2.0 star property
19 km from East Seneca
6.0 out of 10, (882)
"Property looks great , rooms are like prison cells."
United States
crystal l.
The price is 1.927.647 ₫
2.192.666 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Days Inn by Wyndham Tonawanda/Buffalo
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Best Western Galleria Inn & Suites

Best Western Galleria Inn & Suites

Best Western Galleria Inn & Suites
2.5 star property
8.2 km from East Seneca
6.6 out of 10, (1001)
"They were fantastic from check-in through our stay right to check out top notch clean friendly it was a great stay"
United States
Philippe
The price is 2.240.081 ₫
2.548.091 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Best Western Galleria Inn & Suites
Lobby
Comfort Inn University

Comfort Inn University

Comfort Inn University
2.5 star property
18.5 km from East Seneca
8.0 out of 10, Very good, (1204)
"Good place to stay and rest "
United States
Luis
The price is 2.616.723 ₫
2.976.522 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Comfort Inn University
Indoor pool
Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center
3.5 star property
Buffalo Theater District, 14.5 km from East Seneca
8.2 out of 10, Very good, (1670)
"awesome and great location, staff was great, they really make us feel welcome, i really enjoyed here, "
United States
franklin
The price is 3.338.114 ₫
3.897.249 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hyatt Regency Buffalo / Hotel and Conference Center
Indoor pool
Sleep Inn Amherst - Buffalo North near University

Sleep Inn Amherst - Buffalo North near University

Sleep Inn Amherst - Buffalo North near University
2.5 star property
20.9 km from East Seneca
8.8 out of 10, Excellent, (1136)
"Staff is friendly, stores close.by, and hot tub was bubbly"
United States
Tina
The price is 2.170.778 ₫
2.469.260 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Sleep Inn Amherst - Buffalo North near University
Free daily continental breakfast
Hampton Inn Buffalo - Amherst, NY

Hampton Inn Buffalo - Amherst, NY

Hampton Inn Buffalo - Amherst, NY
2.5 star property
18.7 km from East Seneca
9.4 out of 10, Exceptional, (1990)
"The room was very clean and the location was very convenient."
United States
Lee
The price is 2.720.042 ₫
3.094.047 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hampton Inn Buffalo - Amherst, NY
Exterior
Holiday Inn Express Cheektowaga North East by IHG

Holiday Inn Express Cheektowaga North East by IHG

Holiday Inn Express Cheektowaga North East by IHG
2.5 star property
9.3 km from East Seneca
8.4 out of 10, Very good, (1203)
"The lady at the desk (check-in and check-out) was so nice and friendly."
Canada
Maryam
The price is 2.557.890 ₫
2.909.600 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express Cheektowaga North East by IHG
Exterior
La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst
3.0 star property
20.8 km from East Seneca
8.4 out of 10, Very good, (1960)
"Room was spacious and clean, bed was also super comfortable. Would 100% stay again. "
Canada
Allison
The price is 2.016.311 ₫
2.293.554 ₫ total
includes taxes & fees
30 Dec - 31 Dec
La Quinta Inn & Suites by Wyndham Buffalo Amherst
Hallway
Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham
3.5 star property
Buffalo Theater District, 14.3 km from East Seneca
8.6 out of 10, Excellent, (1005)
"I love the history in the hotel "
United States
Dylan
The price is 2.934.852 ₫
3.426.441 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel at the Lafayette Trademark Collection by Wyndham
Exterior
Holiday Inn Express & Suites Tonawanda - Buffalo Area by IHG

Holiday Inn Express & Suites Tonawanda - Buffalo Area by IHG

Holiday Inn Express & Suites Tonawanda - Buffalo Area by IHG
2.5 star property
22.5 km from East Seneca
8.8 out of 10, Excellent, (636)
"Very friendly and helpful staff!"
United States
Andrew
The price is 2.714.771 ₫
3.088.051 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Holiday Inn Express & Suites Tonawanda - Buffalo Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in East Seneca

Find the best East Seneca areas for the activities you enjoy most.
Buffalo which includes a monument, a skyscraper and a city

Downtown Buffalo

Known for its great bars and great live music, there's plenty to explore in Downtown Buffalo. You can visit top attractions like Chippewa District and Statler Tower, and jump on the metro at Fountain Plaza Station or Lafayette Square Station to see more of the city.

Buffalo Theater District

Theatres, live music and restaurants highlight some notable features of Buffalo Theater District. Make a stop by Shea's Performing Arts Center or Chippewa District while you're visiting, and jump aboard the metro at Fountain Plaza Station or Lafayette Square Station to get around town.

Elmwood Village

Elmwood Village is known for its live music, and you can plan a trip to Blue Sky Mausoleum and Ujima Theatre Company while you're in town.

Delaware Park featuring a lake or waterhole

North Buffalo

North Buffalo is well liked for its live music and zoo. If you're hoping to get in some sightseeing, Buffalo Zoo and Buffalo AKG Art Museum are top spots, and you can jump on the metro at Amherst Street Station or Lasalle Station to get around.

Allentown

Allentown is noteworthy for its restaurants, and you can make a stop at top attractions like Wilcox Mansion - Theodore Roosevelt Inaugural National Historic Site and Theater of Youth.

Top East Seneca Hotel Reviews

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Frequently asked questions

What is East Seneca like?
Travellers will be sure to enjoy their time in West Seneca's East Seneca neighbourhood.
If I need to cancel my hotel reservation in East Seneca, will I receive a refund?
Yes! Most hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you have a reservation that's non-refundable, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to view the best deals in East Seneca.
What is there to do in this West Seneca neighbourhood?
A few places to visit in the area around East Seneca include Southgate Plaza, Harvest Hill Golf Course and Charles E. Burchfield Nature and Art Center. You might also plan a visit to Enjoy The Journey Art Gallery when you're sightseeing in West Seneca.