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Check availability on Grand Center Casino Hotels

Our top choices for Grand Center hotels with a casino

Casino
River City Casino & Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1447)
"Awesome place to stay!!"
United States
Kaitlyn
The price is 2.314.753 ₫
3.076.341 ₫ total
includes taxes & fees
21 Dec - 22 Dec
River City Casino & Hotel
Exterior
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1243)
"Great hospitality"
United States
Alejandro
The price is 2.820.110 ₫
3.353.929 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Embassy Suites by Hilton St. Louis Downtown
Exterior
Best Western Plus St. Louis Airport Hotel

Best Western Plus St. Louis Airport Hotel

Best Western Plus St. Louis Airport Hotel
2.5 star property
Woodson Terrace
9.2 out of 10, Wonderful, (1002)
"Room was nice and comfortable, pool was awesome, and breakfast left us all happy"
United States
Letez
The price is 2.884.563 ₫
3.567.955 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Best Western Plus St. Louis Airport Hotel
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1005)
"The staff were awesome "
United States
Corey
The price is 2.935.861 ₫
3.374.096 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Country Inn & Suites by Radisson, St. Charles Historic District
Casino
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.4 out of 10, Very good, (1004)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is 4.002.610 ₫
5.114.081 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Ameristar Casino Resort and Spa
Lobby
The Great Rivers, an Ascend Collection Hotel

The Great Rivers, an Ascend Collection Hotel

The Great Rivers, an Ascend Collection Hotel
3.0 star property
Alton
7.8 out of 10, Good, (758)
"The hotel is being remodeled, so it's hard to give it a fair review."
United States
Stephen
The price is 2.213.471 ₫
2.522.913 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
The Great Rivers, an Ascend Collection Hotel
Lobby
AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End
4.0 star property
Central West End
9.0 out of 10, Wonderful, (683)
"Clean room, Helpful staff, Easy/cheap parking "
United States
Delaney
The price is 3.340.989 ₫
3.939.995 ₫ total
includes taxes & fees
19 Dec - 20 Dec
AC Hotel St. Louis Central West End
Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1003)
"Nice staff at reception. "
United States
Denise
The price is 2.014.064 ₫
2.314.704 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Comfort Suites St Charles - St Louis
Outdoor pool, open 8:00 AM to 8:30 PM, pool umbrellas, pool loungers
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Clayton
8.8 out of 10, Excellent, (676)
"Small rooms but beautiful lobby. "
United States
Debbie
The price is 3.135.794 ₫
3.692.021 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Le Méridien St. Louis Clayton
Blackout curtains, free WiFi, bed sheets
Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach
2.5 star property
Granite City
7.8 out of 10, Good, (572)
"Room was clean, staff were really nice & helpful!! We will be back!"
United States
Shkaia
The price is 1.709.955 ₫
1.935.932 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Red Lion Inn & Suites Pontoon Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Grand Center Hotel Reviews

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Frequently asked questions

Searching for casino hotels in Grand Center?
Heading to Grand Center for some gaming? Lucky for you, you'll find Horseshoe St. Louis Casino, Casino Queen, and River City Casino in the area, plus much more to see and do. Visitors enjoy the theatres, entertainment venues and art galleries. You might want to visit popular sights in the larger area including St. Louis Union Station and Gateway Arch.
How many hotels that are good for gaming will I find in Grand Center?
Win big at one of Expedia's 31 hotels in Grand Center.
What is there to do in Grand Center?
You can head to Washington Avenue Historic District, Ballpark Village or Soulard Farmer's Market to shop for the perfect souvenir. Grand Center is known for its theatres, entertainment venues and art galleries, and you can visit cultural spots such as Grandel Theater and Powell Hall. For more to see and do, you can plan to visit St. Louis Symphony Orchestra and Fox Theater.