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Check availability on Grand Center Spa Hotels

Our top choices for Grand Center hotels with a spa

Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 star property
St. Charles
8.4 out of 10, Very good, (1003)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is 4.010.978 ₫
5.124.773 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Ameristar Casino Resort and Spa
Massages
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1489)
"Room was perfect and parking was a breeze. We really enjoyed the art was wonderful. "
United States
London
The price is 3.338.747 ₫
4.035.773 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
21C Museum Hotel St Louis
Couples treatment room(s), hot tub, body treatments, aromatherapy
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1002)
"The staff was amazing. The bed was so comfortable. "
United States
Mary
The price is 10.943.550 ₫
12.796.183 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Four Seasons Hotel St Louis
Body treatments, aromatherapy, hot stone massages, deep-tissue massages
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5.0 star property
Clayton
9.2 out of 10, Wonderful, (553)
"Service is exceptional!!!"
United States
Jorge
The price is 13.154.638 ₫
15.356.392 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Grand Center Hotel Reviews

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Frequently asked questions

Looking to holiday at a spa hotel in Grand Center?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Discover the theatre scene and opera in Grand Center—your cultural tour starts here. Take in the culture at the art galleries and churches during your stay. Spa hotels are a great way to take a break from your daily routine and add a layer of luxury to your holiday.
What's there to see and do in Grand Center?
Experience Grand Center and visit Powell Symphony Hall, St. Louis Symphony Orchestra and Sheldon Concert Hall. If you have spare time during your trip, you might want to make a stop at Fox Theater and Grandel Theater.
What is a Grand Center spa hotel?
Spa hotels in Grand Center have full on-site spas offering services such as couples massages and a range of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on holiday.