Illinois Medical District Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most. Learn more about Illinois Medical District
A busy city street with tall buildings, a bus, and cars.

Downtown Chicago

5 out of top 10 points of interest in this area

Known for its fascinating museums, stunning river views and gorgeous architecture, there's plenty to explore in Downtown Chicago. Top attractions like Michigan Avenue and Navy Pier are major draws. Catch the metro at State Station or Clark-Lake Station to see more of the city.

Find hotels in Downtown Chicago

Top hotels in Illinois Medical District

The Chicago Hotel Collection Ambassador Gold Coast

The Chicago Hotel Collection Ambassador Gold Coast

4 out of 5
1301 N State Pkwy Chicago IL
Fully refundableReserve now, pay when you stay
The price is 4.046.647 ₫ per night from 27 Jul to 28 Jul
4.046.647 ₫
4.811.277 ₫ total
27 Jul - 28 Jul
includes taxes & fees
8.2/10 Very good! (1,727 reviews)
"Great place in a great location. Restaurant and breakfast buffet were excellent."

Reviewed on 10 Jul 2026

The Chicago Hotel Collection Ambassador Gold Coast
Omni Chicago Hotel

Omni Chicago Hotel

4.5 out of 5
676 N Michigan Ave Chicago IL
Fully refundableReserve now, pay when you stay
The price is 5.448.327 ₫ per night from 9 Aug to 10 Aug
5.448.327 ₫
7.352.844 ₫ total
9 Aug - 10 Aug
includes taxes & fees
9.2/10 Wonderful! (1,895 reviews)
"Unfortunately I didn't have the best experience. I am giving them an okay review because they did attempt to make it right. Without the check out employee in the morning; i probably would have gave this a very poor experience. He did take off the resort fee of $35ish & my $18 breakfast. When I arrived; ..."

Reviewed on 10 Jul 2026

Omni Chicago Hotel
Congress Plaza Hotel

Congress Plaza Hotel

3.5 out of 5
520 South Michigan Avenue Chicago IL
Fully refundableReserve now, pay when you stay
The price is 4.969.566 ₫ per night from 10 Aug to 11 Aug
4.969.566 ₫
5.908.316 ₫ total
10 Aug - 11 Aug
includes taxes & fees
8/10 Very good! (10,218 reviews)
"Our stay was great, best was comfortable and room was clean."

Reviewed on 9 Jul 2026

Congress Plaza Hotel
See all 4,507 properties in Illinois Medical District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Illinois Medical District holiday package cost?
Starting from just , a holiday package is your portal to affordable travel. Custom make your Illinois Medical District trip by picking from our great range of airfares, hotels and rental cars.
How do I get a cheap travel package to Illinois Medical District?
By bundling. Hotels, rental cars and flights — combine whatever you need into an Illinois Medical District holiday package to save loads of cash. Score even more deals when you add extras such as activities or tours to your booking. But that's not the only impressive part. You have the freedom to tailor your holiday your way. We offer more than 550 partner airlines and 1null000null000 hotel options globally, so that everyone has a chance to travel and live out those holiday fantasies.
Where should I stay in Illinois Medical District?
Most travellers who visit Illinois Medical District put both University of Illinois Chicago and United Centre on their sightseeing itineraries. Why not choose a hotel that's close to these great attractions?
What are the top hotels in Illinois Medical District?
Reserve a room at Hyatt Place Chicago Medical/University District. It's one of the area's most in-demand hotels. Another great option in Illinois Medical District is Hyatt House Chicago Medical/University District.
How far in advance should I book my Illinois Medical District holiday?
Browse Expedia to compare international flights as soon as possible. In most cases, you can purchase a seat up to 12 months in advance. If you can't find your preferred air carrier, or you've left things to the last moment, don't worry. The lowest prices to Illinois Medical District sometimes occur just weeks before the date of departure.
What does an Expedia Illinois Medical District travel package include?
That depends on what kind of trip you're contemplating. Illinois Medical District holiday deals can include hotels, car rentals and flights. You can mix and match to create the package that suits your budget and style. You can also add on activities and experiences after you've booked to pick up even bigger discounts.
What should I know before booking an Illinois Medical District travel package?
A travel package can be easier on the wallet than separately booking everything you need for your getaway. For example, combine your hotels, flights and rental cars and save a packet. Whatever type of holiday you have in mind, there's bound to be a package that's perfect for you.
Can I choose my airline with an Illinois Medical District Expedia holiday package?
Most definitely. We offer more than 550 airlines around the world, so you can design your Illinois Medical District trip according to your budget and style.
If I'm not able to travel, can I cancel my Illinois Medical District holiday package?
Certainly, and we're here to help. You may be able to change or cancel your Illinois Medical District holiday package for free if you booked in the last 24 hours. But you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, look up our Customer Service Portal for more information.