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Our top choices for Lewis and Clark Trail Trailhead hotels

Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
3.2 km from Lewis and Clark Trail Trailhead
8.8 out of 10, Excellent, (1003)
"The front desk agent was super nice and the rooms are always clean. They have the best beds in a hotel!"
United States
Jessica
The price is 2.154.543 ₫
2.541.285 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
3.2 km from Lewis and Clark Trail Trailhead
8.6 out of 10, Excellent, (834)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is 2.183.896 ₫
2.575.906 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG
Exterior
Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
3.2 km from Lewis and Clark Trail Trailhead
8.4 out of 10, Very good, (408)
"Nice sized suite, the folks were friendly, the breakfast was better than most. I will stay there again."
United States
Steven
The price is 3.051.612 ₫
3.599.375 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Staybridge Suites O'Fallon Chesterfield by IHG
Property amenity
TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
5.6 km from Lewis and Clark Trail Trailhead
9.0 out of 10, Wonderful, (269)
"Our group comes for the Christmas shopping. It's convenient and close to the Premium outlet stores and is a good base for the additional shopping we do. We stay at the hotel rather than go back and forth from home. Breakfast availability helps save time looking for places to go. Staff has always been friendly and helpful. "
United States
Floyd and Linda
The price is 2.499.165 ₫
2.933.095 ₫ total
includes taxes & fees
25 Dec - 26 Dec
TownePlace Suites by Marriott St. Louis Chesterfield
Lobby sitting area
Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
7.1 km from Lewis and Clark Trail Trailhead
8.8 out of 10, Excellent, (718)
"Clean room, quiet"
United States
Laura
The price is 2.228.626 ₫
2.642.594 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hilton Garden Inn St. Louis/O'Fallon MO
Standard Room, 2 Queen Beds, Non Smoking | Hypo-allergenic bedding, desk, laptop workspace, blackout curtains
Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
6.6 km from Lewis and Clark Trail Trailhead
8.0 out of 10, Very good, (1004)
"Nice and quiet the location is great for softball fields"
United States
James
The price is 2.097.856 ₫
2.533.220 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Comfort Inn & Suites Chesterfield - St. Louis
Free daily full breakfast
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
10.3 km from Lewis and Clark Trail Trailhead
9.0 out of 10, Wonderful, (1004)
"Great hotel!"
United States
Lorelei
The price is 2.762.235 ₫
3.214.220 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
13.6 km from Lewis and Clark Trail Trailhead
9.8 out of 10, Exceptional, (18)
"The room was super clean and tidy. The staff was very friendly and overall a great experience. "
United States
Fred
The price is 1.946.718 ₫
2.237.753 ₫ total
includes taxes & fees
24 Dec - 25 Dec
WoodSpring Suites St Peters-OFallon
Ballroom
The Wildwood Hotel

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
14.7 km from Lewis and Clark Trail Trailhead
9.2 out of 10, Wonderful, (1609)
"Great place!"
United States
Biju
The Wildwood Hotel
BBQ/picnic Area
Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
3.0 star property
10.9 km from Lewis and Clark Trail Trailhead
9.0 out of 10, Wonderful, (577)
"Very clean hotel with great staff "
United States
brad
The price is 2.814.849 ₫
3.275.442 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Courtyard by Marriott St. Louis Chesterfield
Front of property – evening/night
Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
10.9 km from Lewis and Clark Trail Trailhead
8.8 out of 10, Excellent, (846)
"It was great, clean, quiet and friendly! "
United States
Lisa
The price is 2.609.654 ₫
3.036.671 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites St. Louis/Chesterfield
Property amenity
Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
3.0 star property
12.4 km from Lewis and Clark Trail Trailhead
9.6 out of 10, Exceptional, (199)
"Very clean and safe place, wonderful location "
United States
Ashley
The price is 4.972.023 ₫
5.816.671 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Residence Inn by Marriott St. Louis Chesterfield
Standard Room, 2 Queen Beds | Desk, iron/ironing board, free WiFi, bed sheets
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
12.5 km from Lewis and Clark Trail Trailhead
6.8 out of 10, (997)
"Very run down and trash around the property, but the room was clean and comfortable for our one night stop. Convenience of the location"
United States
Natalie
The price is 1.677.071 ₫
1.978.104 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Exterior
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
14.8 km from Lewis and Clark Trail Trailhead
9.6 out of 10, Exceptional, (1039)
"Absolutely amazing stay very nice play our family stays there every time very kid friendly"
United States
Matthew
The price is 3.419.647 ₫
3.966.306 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Drury Plaza Hotel St. Louis Chesterfield
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
13.7 km from Lewis and Clark Trail Trailhead
6.4 out of 10, (1000)
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is 1.699.432 ₫
1.953.496 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Days Inn by Wyndham St Peters/St Charles
Property amenity
Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
15 km from Lewis and Clark Trail Trailhead
9.4 out of 10, Exceptional, (1004)
"Great hotel! Clean, friendly staff, wonderful amenities!"
United States
Susan
The price is 2.893.507 ₫
3.326.257 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites St. Louis St. Peters
Lobby
Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
13.4 km from Lewis and Clark Trail Trailhead
9.2 out of 10, Wonderful, (371)
"Room was very clean and great amenities. Breakfast was decent. Great value"
United States
Marcus
The price is 2.657.007 ₫
3.212.335 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express & Suites St Peters by IHG
Lobby
Relax Inn Saint Charles

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
18.2 km from Lewis and Clark Trail Trailhead
6.6 out of 10, (1000)
"Great place to stay "
United States
Askar
The price is 1.657.341 ₫
1.904.627 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Relax Inn Saint Charles
Lobby
AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield
3.5 star property
13.8 km from Lewis and Clark Trail Trailhead
9.2 out of 10, Wonderful, (241)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is 3.131.128 ₫
3.631.732 ₫ total
includes taxes & fees
25 Dec - 26 Dec
AC Hotel by Marriott St. Louis Chesterfield
Lobby
Economy Inn Wentzville

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
16.1 km from Lewis and Clark Trail Trailhead
6.4 out of 10, (506)
"Parking field safe just off the side of the highway wentzville police is always patrolling actually I was here on Thanksgiving and guess what they had Thanksgiving Day plates they were handing out to people"
United States
Christopher
The price is 1.578.420 ₫
1.790.718 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Economy Inn Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lewis and Clark Trail Trailhead Hotel Reviews

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent
"Clean lobby, super friendly staff, effortless check in. There’s even a small market with food and essentials right next to the check in desk. "
Jen 1-night trip
Posted 7 days ago
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Hotels near other Lewis and Clark Trail Trailhead attractions

Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savour the top-notch restaurants.
See properties
9-11 memorial in New York

9-11 Memorial

3.9/5 (30 reviews)
Learn about the local history of O'Fallon when you spend time at 9-11 Memorial. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Lewis and Clark Trail Trailhead?
Lewis and Clark Trail Trailhead is located in Weldon Spring Heights. You'll find 29 hotels and other accommodations within a few miles for a convenient home base.
How many hotels can I expect to find near Lewis and Clark Trail Trailhead?
Expedia has 29 hotels and other accommodation options a few miles from Lewis and Clark Trail Trailhead.
If I need to cancel the hotel reservation for my stay near Lewis and Clark Trail Trailhead, will I receive a refund?
Yes, most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to get the best options available near Lewis and Clark Trail Trailhead.
What can I see and do near Lewis and Clark Trail Trailhead?
Explore nature at August A. Busch Memorial Conservation Area and Hamburg Trail Trailhead. Missouri Bluffs Golf Course, Golf Headquarters and Babler State Park are worth a stop while you're in the area. St. Louis Premium Outlets and 9-11 Memorial are both worth a visit while you're out exploring.

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