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16 Dec - 17 Dec
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17 Dec - 18 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Medi Center hotels

Sanctuary 4 Bedroom Historic Church | In-room dining
Good Life Vacation Rental Resort

Good Life Vacation Rental Resort

Good Life Vacation Rental Resort
2.0 star property
1.7 km from Medi Center
9.4 out of 10, Exceptional, (31)
"The area around the property is old, but felt totally safe inside the property. Inside was very nice! Would stay again!"
United States
Jamie
Good Life Vacation Rental Resort
Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Lodge at 32nd

Lodge at 32nd

Lodge at 32nd
2.5 star property
1.8 km from Medi Center
7.6 out of 10, Good, (800)
"Great place for the money "
United States
Isabel
The price is 1.565.301 ₫
2.061.545 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Lodge at 32nd
Free daily continental breakfast
Quality Inn San Diego I-5 Naval Base

Quality Inn San Diego I-5 Naval Base

Quality Inn San Diego I-5 Naval Base
2.5 star property
3.2 km from Medi Center
7.8 out of 10, Good, (875)
"Everything was really fine!"
United States
Sebastian Alejandro
The price is 2.462.803 ₫
2.781.613 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Quality Inn San Diego I-5 Naval Base
Memory-foam beds, blackout curtains, iron/ironing board, free WiFi
Stay Classy Hostel

Stay Classy Hostel

Stay Classy Hostel
2.0 star property
East Village, 4.2 km from Medi Center
9.6 out of 10, Exceptional, (786)
"Good place to stay "
United States
sai
Stay Classy Hostel
Premium bedding, pillow-top beds, desk, laptop workspace
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

Sentral Gaslamp Quarter
4.0 star property
East Village, 4.6 km from Medi Center
9.2 out of 10, Wonderful, (598)
"It was nice stay! "
United States
Chashawna
The price is 3.108.763 ₫
4.367.003 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Sentral Gaslamp Quarter
Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board
Rodeway Inn National City San Diego South

Rodeway Inn National City San Diego South

Rodeway Inn National City San Diego South
2.0 star property
3.8 km from Medi Center
6.6 out of 10, (224)
"staff was kind, free parking, only thing was the room I got smelled really bad "
United States
Sofia
The price is 1.722.120 ₫
1.894.332 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Rodeway Inn National City San Diego South
Rooftop terrace
Porto Vista Hotel Downtown

Porto Vista Hotel Downtown

Porto Vista Hotel Downtown
3.5 star property
Little Italy, 5.9 km from Medi Center
6.8 out of 10, (1202)
"Nice stay, staff excellent, friendly, helpful and great customer service. Hotel ok older"
United States
Mizael
Porto Vista Hotel Downtown
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.4 out of 10, Exceptional, (1003)
"Great location "
United States
Mohammad
The price is 2.344.399 ₫
3.478.630 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Lobby sitting area
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.2 out of 10, Wonderful, (2058)
"Very comfortable, nice location and good service "
United States
ALEXANDER
The price is 4.898.202 ₫
6.869.049 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Omni San Diego Hotel at the Ballpark
In-room safe, desk, laptop workspace, iron/ironing board
Holiday Inn Express San Diego South - National City by IHG

Holiday Inn Express San Diego South - National City by IHG

Holiday Inn Express San Diego South - National City by IHG
2.5 star property
4.2 km from Medi Center
8.4 out of 10, Very good, (1000)
"Fine place "
United States
andrew
The price is 2.789.072 ₫
3.073.418 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express San Diego South - National City by IHG
3 restaurants, breakfast, lunch, dinner served; seafood
Pendry San Diego

Pendry San Diego

Pendry San Diego
5.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.2 out of 10, Wonderful, (1005)
"Excellent Stay at Pendry - will definitely return when visiting San Diego"
Canada
Bobbi Jo
The price is 6.709.560 ₫
9.161.305 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Pendry San Diego
Exterior
Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG
4.0 star property
East Village, 4.7 km from Medi Center
8.8 out of 10, Excellent, (1005)
"Large, comfy room, good service, good location"
United States
Thanapong
The price is 3.341.624 ₫
4.850.622 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hotel Indigo San Diego-Gaslamp Quarter by IHG
Standard Quadruple Room, Mixed Dorm | Shared kitchen facilities | Fridge, microwave, stovetop, toaster
Gaslamp Hostel

Gaslamp Hostel

Gaslamp Hostel
2.0 star property
Gaslamp Quarter, 5.1 km from Medi Center
9.2 out of 10, Wonderful, (537)
"Never had this much fun in time of a simple night stay! Great accessibility as well. "
United States
Dulce de la
Gaslamp Hostel
Exterior
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
4.0 star property
Gaslamp Quarter, 5.1 km from Medi Center
9.2 out of 10, Wonderful, (620)
"Great stay"
United States
Angelica
The price is 3.657.368 ₫
4.240.534 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
View from property
San Diego Downtown Lodge

San Diego Downtown Lodge

San Diego Downtown Lodge
2.0 star property
4.7 km from Medi Center
6.2 out of 10, (1002)
"The staff are really nice here. A convenient location. "
United States
Emmanuel
San Diego Downtown Lodge
View from property
Moxy San Diego Downtown/Gaslamp Quarter

Moxy San Diego Downtown/Gaslamp Quarter

Moxy San Diego Downtown/Gaslamp Quarter
3.5 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.0 out of 10, Wonderful, (1005)
"The room was clean and comfortable, the staff courteous. A lot of nice places to eat close by."
United States
Keyur Dhananjay
The price is 2.986.938 ₫
3.700.013 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Moxy San Diego Downtown/Gaslamp Quarter
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.0 out of 10, Wonderful, (1165)
"Amenities and location were great. "
United States
Julie
The price is 4.002.055 ₫
5.707.924 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.0 out of 10, Wonderful, (1230)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is 3.606.849 ₫
4.181.962 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.0 out of 10, Wonderful, (3156)
"the staff was very accommodating and the food options nearby were all very delicious!"
United States
Maerene
The price is 4.475.671 ₫
6.398.815 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hard Rock Hotel San Diego
Terrace/patio
Hostel on 3rd

Hostel on 3rd

Hostel on 3rd
1.0 star property
Marina District, 5.2 km from Medi Center
6.2 out of 10, (231)
"It is a great spot the location couldn’t have been better. Staff were helpful and I had no issues with the room. It was quiet enough with the other guests present. Awesome bang for your buck!"
Canada
Scott
Hostel on 3rd
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Medi Center Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Clean rooms, friendly staff"
Marie 1-night trip
Posted 2 days ago
Courtyard by Marriott San Diego Downtown Little Italy

Hotels near other Medi Center attractions

Nu-Way Christian Ministries

Find out about the history of San Diego with a stop at Nu-Way Christian Ministries.
See properties

Pilgrim Progressive Baptist Church

Pilgrim Progressive Baptist Church is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels?
See properties

Frequently asked questions

What's the area like around Medi Center?
Medi Center is located in San Diego. If you're looking for a convenient place to stay, take a look at the 24 hotels and other accommodation options you'll find within a mile.
How many hotels should I expect to find near Medi Center?
Expedia has 24 hotels and other accommodation options within a mile from Medi Center.
If I need to cancel the hotel reservation for my stay near Medi Center, will I receive a refund?
Yes, most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view top deals close to Medi Center.
What can I see and do near Medi Center?
San Diego Natural History Museum, San Diego Museum of Art and San Diego Air and Space Museum feature a variety of fascinating exhibits to see while you're in town. Hotel del Coronado, California Tower and Star of India are some of the notable landmarks to see in the area. You can watch performances at Old Globe Theater, San Diego Civic Theatre and The Rady Shell at Jacobs Park if you're interested in local theatre.

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