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21 Dec - 22 Dec
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Our top choices for Medi Center hotels

Sanctuary 4 Bedroom Historic Church | In-room dining
Good Life Vacation Rental Resort

Good Life Vacation Rental Resort

Good Life Vacation Rental Resort
2.0 star property
1.7 km from Medi Center
9.4 out of 10, Exceptional, (32)
"The area around the property is old, but felt totally safe inside the property. Inside was very nice! Would stay again!"
United States
Jamie
Good Life Vacation Rental Resort
Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Lodge at 32nd

Lodge at 32nd

Lodge at 32nd
2.5 star property
1.8 km from Medi Center
7.6 out of 10, Good, (801)
"Great place for the money "
United States
Isabel
The price is 1.828.629 ₫
2.358.350 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Lodge at 32nd
Free daily continental breakfast
Quality Inn San Diego I-5 Naval Base

Quality Inn San Diego I-5 Naval Base

Quality Inn San Diego I-5 Naval Base
2.5 star property
3.2 km from Medi Center
7.8 out of 10, Good, (876)
"Everything was really fine!"
United States
Sebastian Alejandro
The price is 2.463.084 ₫
2.781.929 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Quality Inn San Diego I-5 Naval Base
Memory-foam beds, blackout curtains, iron/ironing board, free WiFi
Stay Classy Hostel

Stay Classy Hostel

Stay Classy Hostel
2.0 star property
East Village, 4.2 km from Medi Center
9.6 out of 10, Exceptional, (786)
"Good place to stay "
United States
sai
Stay Classy Hostel
Premium bedding, pillow-top beds, desk, laptop workspace
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

Sentral Gaslamp Quarter
4.0 star property
East Village, 4.6 km from Medi Center
9.2 out of 10, Wonderful, (605)
"It was nice stay! "
United States
Chashawna
The price is 2.885.440 ₫
4.108.035 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Sentral Gaslamp Quarter
Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board
Rodeway Inn National City San Diego South

Rodeway Inn National City San Diego South

Rodeway Inn National City San Diego South
2.0 star property
3.8 km from Medi Center
6.6 out of 10, (224)
"staff was kind, free parking, only thing was the room I got smelled really bad "
United States
Sofia
The price is 1.744.685 ₫
1.919.153 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Rodeway Inn National City San Diego South
Suite, 1 King Bed with Sofa bed, City View | View from room
Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
4.9 km from Medi Center
9.4 out of 10, Exceptional, (1009)
"Room was spacious! Best hotel I’ve ever been to! "
United States
Liyah
The price is 3.552.525 ₫
4.118.975 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Marriott Vacation Club®, San Diego
Rooftop terrace
Porto Vista Hotel Downtown

Porto Vista Hotel Downtown

Porto Vista Hotel Downtown
3.5 star property
Little Italy, 5.9 km from Medi Center
6.8 out of 10, (1202)
"Nice stay, staff excellent, friendly, helpful and great customer service. Hotel ok older"
United States
Mizael
Porto Vista Hotel Downtown
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.4 out of 10, Exceptional, (1004)
"Great location "
United States
Mohammad
The price is 2.344.666 ₫
3.479.028 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Classic Studio | In-room dining
The Artifact Hotel

The Artifact Hotel

The Artifact Hotel
2.0 star property
East Village, 4.7 km from Medi Center
9.2 out of 10, Wonderful, (45)
"Room was great, the hosts were fantastic and communicative. Absolutely will plan to stay here again in the future! "
United States
Aulani
The price is 2.294.668 ₫
5.997.452 ₫ total
includes taxes & fees
23 Dec - 24 Dec
The Artifact Hotel
In-room safe, desk, laptop workspace, iron/ironing board
Holiday Inn Express San Diego South - National City by IHG

Holiday Inn Express San Diego South - National City by IHG

Holiday Inn Express San Diego South - National City by IHG
2.5 star property
4.2 km from Medi Center
8.4 out of 10, Very good, (1002)
"Fine place "
United States
andrew
The price is 3.078.855 ₫
3.392.744 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express San Diego South - National City by IHG
Lobby sitting area
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.2 out of 10, Wonderful, (2049)
"Very comfortable, nice location and good service "
United States
ALEXANDER
The price is 5.122.438 ₫
7.129.174 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Omni San Diego Hotel at the Ballpark
3 restaurants, breakfast, lunch, dinner served; seafood
Pendry San Diego

Pendry San Diego

Pendry San Diego
5.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.2 out of 10, Wonderful, (1002)
"Excellent Stay at Pendry - will definitely return when visiting San Diego"
Canada
Bobbi Jo
The price is 7.236.625 ₫
9.773.358 ₫ total
includes taxes & fees
15 Jan - 16 Jan 2026
Pendry San Diego
Exterior
Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG
4.0 star property
East Village, 4.7 km from Medi Center
8.8 out of 10, Excellent, (1005)
"Large, comfy room, good service, good location"
United States
Thanapong
The price is 3.789.360 ₫
5.369.839 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Indigo San Diego-Gaslamp Quarter by IHG
Standard Quadruple Room, Mixed Dorm | Shared kitchen facilities | Fridge, microwave, stovetop, toaster
Gaslamp Hostel

Gaslamp Hostel

Gaslamp Hostel
2.0 star property
Gaslamp Quarter, 5.1 km from Medi Center
9.2 out of 10, Wonderful, (539)
"Great location with clean, comfortable rooms. Amazing ambiance and professional staff. I would stay hear again."
United States
Anthony Michael
Gaslamp Hostel
Exterior
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
4.0 star property
Gaslamp Quarter, 5.1 km from Medi Center
9.2 out of 10, Wonderful, (623)
"Great stay"
United States
Angelica
The price is 3.920.935 ₫
4.546.129 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
View from property
Moxy San Diego Downtown/Gaslamp Quarter

Moxy San Diego Downtown/Gaslamp Quarter

Moxy San Diego Downtown/Gaslamp Quarter
3.5 star property
Gaslamp Quarter, 4.9 km from Medi Center
9.0 out of 10, Wonderful, (1006)
"The staff was amazing, friendly, helpful and attentive. "
United States
Jan
The price is 2.987.279 ₫
3.700.435 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Moxy San Diego Downtown/Gaslamp Quarter
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.0 out of 10, Wonderful, (1238)
"Nice Residence Inn"
United States
Terry
The price is 3.607.260 ₫
4.182.438 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 5 km from Medi Center
9.0 out of 10, Wonderful, (3168)
"Great stay"
United States
Laurence
The price is 4.476.181 ₫
6.399.564 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hard Rock Hotel San Diego
View from property
San Diego Downtown Lodge

San Diego Downtown Lodge

San Diego Downtown Lodge
2.0 star property
4.7 km from Medi Center
6.2 out of 10, (1000)
"The staff are really nice here. A convenient location. "
United States
Emmanuel
San Diego Downtown Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Medi Center Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Clean room and friendly staff. Great views for the city. "
Marco 2-night trip
Posted 23 hours ago
Courtyard by Marriott San Diego Downtown Little Italy

Hotels near other Medi Center attractions

Nu-Way Christian Ministries

Find out about the history of San Diego with a stop at Nu-Way Christian Ministries.
See properties

Pilgrim Progressive Baptist Church

Pilgrim Progressive Baptist Church is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels?
See properties

Frequently asked questions

What's the area like around Medi Center?
Medi Center is located in San Diego. If you're looking for a convenient place to stay, take a look at the 26 hotels and other accommodation options you'll find within a mile.
How many hotels should I expect to find near Medi Center?
Expedia has 26 hotels and other accommodation options within a mile from Medi Center.
If I need to cancel the hotel reservation for my stay near Medi Center, will I receive a refund?
Yes, most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view top deals close to Medi Center.
What can I see and do near Medi Center?
San Diego Natural History Museum, San Diego Museum of Art and San Diego Air and Space Museum feature a variety of fascinating exhibits to see while you're in town. Hotel del Coronado, California Tower and Star of India are some of the notable landmarks to see in the area. You can watch performances at Old Globe Theater, San Diego Civic Theatre and The Rady Shell at Jacobs Park if you're interested in local theatre.