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Our top choices for Mississippi River hotels

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (361 reviews)
"Staff was really nice and helpful."
United States
rhonda
The price is 2.104.000 ₫
2.388.829 ₫ total
includes taxes & fees
23 Mar - 24 Mar
River's Edge Motel

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (22 reviews)
"Best place to stay in town!"
United States
Kimberly
The price is 3.497.900 ₫
3.971.429 ₫ total
includes taxes & fees
23 Mar - 24 Mar
The Eagles Nest Inn

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
26.3 km from Mississippi River
6.4 out of 10, (746 reviews)
"It was ok as a hotel stay for over night, even tho baymont took it over, it isnt any better. The owner i think lives there, there wasnt any towels in our room. I didnt get a friendly vibe from them at all. "
United States
Michelle
The price is 1.656.900 ₫
1.915.955 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Baymont by Wyndham Hannibal

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1,005 reviews)
"Tony did a great job at front desk answering all our questions about the room and Hannibal."
United States
Steven
The price is 3.182.037 ₫
3.654.385 ₫ total
includes taxes & fees
27 Mar - 28 Mar
Best Western On The River

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (170 reviews)
"Great place to stay!"
United States
Sandy
The price is 3.741.840 ₫
5.203.671 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Riverside Inn Hannibal

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,001 reviews)
"Would highly recommend to anyone needed an excellent hotel"
United States
Elizabeth
The price is 2.883.795 ₫
3.340.876 ₫ total
includes taxes & fees
12 Apr - 13 Apr
Sleep Inn & Suites Hannibal West

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
90.7 km from Mississippi River
6.8 out of 10, (1,001 reviews)
"Staff was awesome and accomodating. Room and price was great. "
United States
Anthony
The price is 1.833.110 ₫
2.162.152 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
86.8 km from Mississippi River
6.4 out of 10, (521 reviews)
"Really cozy place to stay at!"
United States
Yufei
The price is 1.578.000 ₫
1.790.241 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Economy Inn Wentzville

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (25 reviews)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is 4.440.965 ₫
5.100.448 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Lighthouse Inn & Suites

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (679 reviews)
"The front desk woman was so helpful and kind. The location was extremely clean, the breakfast was honestly one of the best I have had for a free continental breakfast, and I loved the hot tub. I felt very safe. Beds were comfortable. Great location. "
United States
Kayleigh
The price is 2.248.650 ₫
2.661.475 ₫ total
includes taxes & fees
29 Mar - 30 Mar
Comfort Inn & Suites - Hannibal

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.4 out of 10, Very good, (39 reviews)
"Great location. Clean rooms, Staff very friendly."
United States
Charles
The price is 2.535.051 ₫
2.911.507 ₫ total
includes taxes & fees
12 Apr - 13 Apr
Garden House Bed and Breakfast

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1,001 reviews)
"Excellent hotel with great bathroom amenities and an excellent breakfast. Our traveling companion said the biscuits and gravy were the best she'd ever had. Highly recommend this hotel and the included breakfast"
United States
Wendy
The price is 2.115.046 ₫
2.450.281 ₫ total
includes taxes & fees
12 Apr - 13 Apr
Quality Inn & Suites Hannibal West

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1,001 reviews)
"Great stay with no issues at all."
Canada
Thomas
The price is 1.472.537 ₫
1.691.353 ₫ total
includes taxes & fees
24 Mar - 25 Mar
Motel 6 Hannibal, MO

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
93.8 km from Mississippi River
6.2 out of 10, (1,002 reviews)
"Everything was good "
United States
Carol
The price is 1.788.400 ₫
2.055.766 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Days Inn by Wyndham St Peters/St Charles

LAKEVIEWINN

LAKEVIEWINN
2.5 star property
89.4 km from Mississippi River
5.8 out of 10, (37 reviews)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
United States
Evelyn
The price is 1.775.250 ₫
2.005.145 ₫ total
includes taxes & fees
23 Mar - 24 Mar
LAKEVIEWINN

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk
2.5 star property
96.1 km from Mississippi River
6.2 out of 10, (498 reviews)
"Loved the staff very friendly and welcoming! Room was amazing! "
United States
Lexys
The price is 1.704.240 ₫
1.908.749 ₫ total
includes taxes & fees
29 Mar - 30 Mar
Baymont by Wyndham Keokuk

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1,002 reviews)
"Clean rooms, easy check in, friendly staff, awesome location "
United States
Rhonda
The price is 1.624.025 ₫
1.865.193 ₫ total
includes taxes & fees
29 Mar - 30 Mar
Super 8 by Wyndham Hannibal

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
3.0 star property
109.6 km from Mississippi River
6.6 out of 10, (1,001 reviews)
"Enjoy our stay very nice clean neat breakfast fresh and staff helpful and pleasant "
United States
Tatiana
The price is 1.833.110 ₫
2.240.756 ₫ total
includes taxes & fees
5 Apr - 6 Apr
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (158 reviews)
"Truth is that this place was a great value. The rooms and inside were very clean and the staff was excellent. Value for price is exceptional. "
United States
James
The price is 1.499.100 ₫
1.733.696 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Howard Johnson BY Wyndham Hannibal

Sleep Inn Saint Charles North

Sleep Inn Saint Charles North
2.5 star property
97.1 km from Mississippi River
5.8 out of 10, (525 reviews)
"Listing was completely false there is no pool that will ever be operational supposed to be a suite that sleeps 4 but hide a bed had no bedding and when I asked for some all they would give me was 2 very old thin blankets no sheet no pillow both the other beds were stained and dirty there was no toilet paper windows were boarded up on building and was just not what they represented online "
United States
Levi
The price is 1.696.087 ₫
1.949.263 ₫ total
includes taxes & fees
4 Apr - 5 Apr
Sleep Inn Saint Charles North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mississippi River

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Property grounds
River's Edge Motel
2.0 star property
9.0
Wonderful
361 reviews
View
Interior
The Eagles Nest Inn
3.0 star property
9.4
Exceptional
22 reviews
View
Indoor pool
Baymont by Wyndham Hannibal
2.5 star property
6.4
746 reviews
View
Desk, iron/ironing board, WiFi, bed sheets
Best Western On The River
2.5 star property
8.6
Excellent
1,005 reviews
View
Honeymoon Room, River View | Egyptian cotton sheets, premium bedding, pillow-top beds
Riverside Inn Hannibal
2.5 star property
9.4
Exceptional
170 reviews
View

Top Mississippi River Hotel Reviews

Hotels near other Mississippi River attractions

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.