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Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

1. Depot Inn and Suites

La Plata

JERROD

2.559.942 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A buffet with various food items, including omelets and other dishes, arranged in metal serving trays.

2. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Jimmy

3.251.188 ₫ total

includes taxes & fees

28 Nov - 29 Nov

A bathroom with a large bathtub, a chair, and a small shelf with plants.

3. Pinemark Inn & Suites

St. Clair

Michael

3.801.990 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

4. Sleep Inn & Suites Hannibal West

Hannibal

ELAINE

3.201.462 ₫ total

includes taxes & fees

25 Nov - 26 Nov

A Comfort Inn hotel with a modern design, featuring a covered entrance and a clear sky in the background.

5. Comfort Inn Sullivan

Sullivan

Sammy

3.206.582 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

6. Best Western On The River

Hannibal

Wei

3.516.008 ₫ total

includes taxes & fees

1 Nov - 2 Nov

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

7. Quality Inn & Suites Hannibal West

Hannibal

Gayle

2.396.512 ₫ total

includes taxes & fees

23 Nov - 24 Nov

A modern kitchen with a dining area, featuring a kitchen island with appliances and a coffee station.

8. Super 8 by Wyndham Kirksville-University Area

Kirksville

Michael

1.828.136 ₫ total

includes taxes & fees

26 Nov - 27 Nov

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

9. Best Western Plus Washington Hotel

Washington

Carl

3.941.209 ₫ total

includes taxes & fees

12 Nov - 13 Nov

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

10. Oak Hill Inn & Suites

Canton

Regina

2.980.971 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a desk, a chair, and a large window.

11. Super 8 by Wyndham Washington

Washington

Kenneth

2.355.902 ₫ total

includes taxes & fees

16 Nov - 17 Nov

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

12. Hampton Inn By Hilton Warrenton I-70

Warrenton

Tammy

4.238.066 ₫ total

includes taxes & fees

3 Nov - 4 Nov

A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.

13. Travelier Motel

Macon

Dovey

2.153.780 ₫ total

includes taxes & fees

29 Oct - 30 Oct

A modern hotel lobby with a high ceiling, a central seating area with sofas and a coffee table, and a flat-screen TV mounted on the wall.

14. Drury Inn & Suites Southwest St. Louis

Valley Park

Michael

3.596.197 ₫ total

includes taxes & fees

11 Nov - 12 Nov

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

15. The Wildwood Hotel

Wildwood

Lori

2.488.918 ₫ total

includes taxes & fees

11 Nov - 12 Nov

A swimming pool with a metal ladder, surrounded by chairs and large windows offering a view of the sunset.

16. La Quinta Inn & Suites by Wyndham St Louis Route 66

St. Louis

Edward

2.960.834 ₫ total

includes taxes & fees

29 Oct - 30 Oct

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

17. Comfort Inn Near Six Flags St. Louis

Pacific

Jade

2.644.504 ₫ total

includes taxes & fees

18 Nov - 19 Nov

A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

18. Holiday Inn Express & Suites St Peters by IHG

St. Peters

Roxanne

3.663.803 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A modern interior with hanging pendant lights, large windows, and a view of the outside.

19. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Fenton

michael

2.662.789 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a central round table, two sofas, and a chandelier.

20. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Stephanie

3.895.065 ₫ total

includes taxes & fees

2 Nov - 3 Nov

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Holiday Rentals in Northeast Missouri

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Cottage

A patio with a fire pit, outdoor furniture, and a wooden deck.

Downtown Hermann Vacation Home Near Wineries!

Hermann

"This is a very cute little house on the end of a quiet street. It's within easy walking distance of all the shops, restaurants, wineries, distilleries, and bars between 1st Street and 5th Street. If you don't mind a longer, hillier walk you could also go further south to City Park or to Stone Hill winery. But there's also easy transportation on the Trolley or local ride services. We were happy to find there were more beds than pictured (3 queen size downstairs between 2 bedrooms, and 2 queens...

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Treehouse

A wooden bridge leading to a two-story house with multiple windows and a covered porch.

The Cottage

Hermann

"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Holiday Home

A two-story building with a balcony, outdoor seating area, and string lights.

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Mount Pleasant

"The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc"

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Cottage

Updated Missouri Cabin Rental on Large Farm

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A wooden dock extending into a calm lake surrounded by lush greenery.

Charming Berger Apt on 42-acre Farm w/ Pool Access

Berger

Apartment

A red building with a sign for 'Catala House' and a 'Massage House' sign.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Apartment

A living room with a sofa, armchair, and coffee table. There is a ceiling fan, a TV mounted on the wall, and a window with blinds.

Walk to Carondelet Park: Quiet Couple's Getaway

Carondelet

"We had a nice stay, close to things we wanted to do"

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

Why not visit the animals who live at St. Louis Zoo and see why this is a favourite attraction in St. Louis? Amble around the area's lush forest or attend a sporting event.

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Learn more about Northeast Missouri

Great live music, sports teams and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theatres.

See all hotels in Northeast Missouri

A large eye sculpture in a park surrounded by trees.

Top Northeast Missouri Hotel Reviews

The Westin St. Louis

10/10 Excellent

"They do valet parking but it ends at a certain hour I guess cause I had to park my own car after 9"

Ameristar Casino Resort and Spa

10/10 Excellent

"I was kind of worried staying here, especially with the deal that was going on but truly no regrets. Upon check in, they had multiple staff members available which is uncommon these days and they were nice. We booked a regular king suite and it was huge and spotless! They have an indoor/outdoor pool and jacuzzi available, they were huge. We did stay during the week so the restaurants were not operating at they do on the weekends but they still have a little “deli” available all night with some quick decent options or you can always doordash. They serve coffee/breakfast as well. I did not know until we went to the casino that people could smoke. The upper level of the casino is non smoking but there was no bar up there, not really any people either so we decided to just be mindful of where we sat down stairs. Bar is reasonably priced as well. The only thing that I found annoying was that the machines would be dirty as in cigarette ashes and ashtrays so I would have to move along to find something clean. They have vending available by the check in desk and in the same hallway as the casino. Definitely would return."