Otay Mesa Travel Guide

San Diego


Popular places to visit


Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
The price is 3.217.506 ₫ per night from 28 Aug to 29 Aug
3.217.506 ₫
3.659.913 ₫ total
28 Aug - 29 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
7.8/10 Good! (1,433 reviews)
"Staff"

Reviewed on 13 Aug 2025

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the pool and the bar in their ...
8/10 Very Good! (1,979 reviews)
"Nice room with closet (not pictured anywhere i could find) Quiet, dark, good air conditioning. Pillows leave something to be desired but bed was comfortable. Pool was perfect temperature but jacuzzi was over chlorinated. Only issue I had was there was never any water in the container that was located ..."

Reviewed on 19 Aug 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is 4.003.523 ₫ per night from 1 Sept to 2 Sept
4.003.523 ₫
5.299.710 ₫ total
1 Sept - 2 Sept
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,869 reviews)
"Overall a good stay 7/10 no wow factors but still worth the money"

Reviewed on 19 Aug 2025

Wyndham San Diego Bayside
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is 4.446.897 ₫ per night from 26 Aug to 27 Aug
4.446.897 ₫
5.111.486 ₫ total
26 Aug - 27 Aug
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,656 reviews)
"I had a wonderful stay at The Dana on Mission Bay! The location is unbeatable—right on the water and just minutes from SeaWorld and downtown San Diego. My room was clean, spacious, and had beautiful views of the bay. The pools were relaxing, and I loved being able to walk along the waterfront. Firefly ..."

Reviewed on 19 Aug 2025

The Dana on Mission Bay
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
The price is 2.926.006 ₫ per night from 1 Sept to 2 Sept
2.926.006 ₫
3.392.558 ₫ total
1 Sept - 2 Sept
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful ...
7.8/10 Good! (1,110 reviews)
"stayed here for my birthday. staff was really nice. room was smaller than we thought and breakfast was $20 per person, not good either :("

Reviewed on 20 Aug 2025

The DEXTRO Little Italy, BW Premier Collection
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
1500 Orange Ave, Coronado, CA
Fully refundableReserve now, pay when you stay
The price is 7.892.120 ₫ per night from 14 Sept to 15 Sept
7.892.120 ₫
10.226.063 ₫ total
14 Sept - 15 Sept
includes taxes & fees
Stay at this 4-star beach resort in Coronado. Enjoy free Wi-Fi, 6 restaurants and a private beach. Our guests praise the helpful staff and the property condition ...
7.8/10 Good! (1,013 reviews)
"Whats not to like 😊"

Reviewed on 20 Aug 2025

Hotel del Coronado, Curio Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

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Mid-City

While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Gaslamp Quarter
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Downtown San Diego

4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Downtown San Diego
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North Park

North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

North Park
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Little Italy

Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.

Little Italy
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Del Cerro

While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.

Del Cerro


Otay Mesa Travel Guide

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