Search Spa Hotels in San Francisco

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on San Francisco Spa Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top San Francisco Spa Hotels

Couples treatment room(s), sauna, hot tub, steam room
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 star property
San Francisco
8.4 out of 10, Very good, (1246)
"Its a very beautiful hotel with view and very good breakfast "
United States
Patrick
The price is 3.472.646 ₫
3.819.911 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Megapolis Hotel Panamá
Couples treatment room(s), sauna, hot tub, steam room
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4.0 star property
San Francisco
8.6 out of 10, Excellent, (1425)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is 2.091.890 ₫
2.301.079 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Decapolis Hotel Panama City
Executive Suite, 1 King Bed, Partial Ocean View | Bathroom | Separate bathtub and shower, designer toiletries, hair dryer, slippers
JW Marriott Panama

JW Marriott Panama

5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"Spotless, friendly and great food. Great pools a restaurants. "
Canada
David
The price is 6.622.763 ₫
7.285.039 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
JW Marriott Panama
Treatment room
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1032)
"Wonderful stay!"
United States
Martha
The price is 4.248.221 ₫
4.673.122 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Las Americas Golden Tower Panama
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2126)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
The price is 2.229.837 ₫
2.452.953 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Plaza Paitilla Inn Hotel
Couples treatment room(s), sauna, hot tub, Turkish bath/hammam
Sheraton Grand Panama

Sheraton Grand Panama

4.0 star property
San Francisco
8.6 out of 10, Excellent, (988)
"Great staff. Great restaurants and bakery. "
United States
Duncan Eric
The price is 3.560.355 ₫
3.916.391 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Sheraton Grand Panama
Outdoor pool
Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments

4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is 4.219.680 ₫
8.674.080 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Wanders Panama by Boutique Apartments
Outdoor pool
Wanders & Yoo

Wanders & Yoo

4.0 star property
San Francisco
8.8 out of 10, Excellent, (9)
"Cool and modern condos, great location and views."
United States
Jorge
The price is 7.690.367 ₫
8.459.404 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Wanders & Yoo
Exterior
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5.0 star property
Veracruz
8.0 out of 10, Very good, (1000)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is 4.386.357 ₫
4.824.993 ₫ total
includes taxes & fees
16 Dec - 17 Dec
The Westin Playa Bonita Panama
Lobby
Hyatt Regency Panama City

Hyatt Regency Panama City

4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (115)
"Great hotel fair price"
United States
Santiago
The price is 3.322.998 ₫
3.655.298 ₫ total
includes taxes & fees
13 Dec - 14 Dec
Hyatt Regency Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top San Francisco Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in San Francisco?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Make sure you enjoy the many popular restaurants during your stay. Hotels with spas are a great way to take a break from your routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in San Francisco?
Among Expedia's 214 accommodation options in San Francisco, there are 5 spa hotels.
What's there to see and do in San Francisco?
Enjoy San Francisco and visit Multiplaza Pacific Mall, Calle 50 and Avenida Balboa. If you have spare time during your trip, you might want to make a stop at Panama Canal Murals and Pacific Center.
What is a San Francisco spa hotel?
Spa hotels in San Francisco provide lodging and have an on-site spa which offers services such as couples massages and body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.