Search Luxury Hotels in Santa Cruz

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Cruz Luxury Hotels

Our top choices for Santa Cruz luxury hotels

Lobby
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5.0 star property
Historical Center
9.4 out of 10, Exceptional, (1004)
"Amazing and beautiful historic building but with modernised fittings with really helpful staff and great facilities. And all the key historic sites are within an easy walk of the hotel"
United Kingdom
Christopher
The price is 11.078.792 ₫
12.186.671 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
City view from property
EME Catedral Mercer Hotel

EME Catedral Mercer Hotel

5.0 star property
Historical Center
8.8 out of 10, Excellent, (1002)
"A great hotel in a fabulous location. We thoroughly enjoyed our stay. Most of the staff were excellent and very helpful and friendly. A small criticism would be on the breakfast, which is quite moderate in terms of range and quality. But we would certainly stay here again. "
United Kingdom
Leo Roderick
The price is 5.021.865 ₫
5.524.051 ₫ total
includes taxes & fees
10 Dec - 11 Dec
EME Catedral Mercer Hotel
Courtyard
El Rey Moro Hotel Boutique

El Rey Moro Hotel Boutique

4.0 star property
Historical Center
9.4 out of 10, Exceptional, (890)
"Great location, clean, quite and nice restaurant "
United States
Mark
The price is 2.714.876 ₫
2.986.517 ₫ total
includes taxes & fees
17 Dec - 18 Dec
El Rey Moro Hotel Boutique
Courtyard
Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla

4.0 star property
Historical Center
9.8 out of 10, Exceptional, (859)
"Excellent hotel. Beautiful "
United States
Nefer
The price is 5.210.185 ₫
5.731.204 ₫ total
includes taxes & fees
10 Dec - 11 Dec
Hotel Boutique Casa del Poeta Sevilla
Seasonal outdoor pool
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4.0 star property
Historical Center
9.2 out of 10, Wonderful, (1003)
"The property had real historic character - in a great location with helpful and friendly staff "
United Kingdom
Caroline Jane
The price is 3.361.636 ₫
3.697.800 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Las Casas de la Judería, Sevilla Historic City Center
Rooftop terrace
Hotel Fernando III

Hotel Fernando III

4.0 star property
Historical Center
9.6 out of 10, Exceptional, (1532)
"Great location & staff were wonderful!"
United States
Fawn
The price is 8.287.356 ₫
9.116.092 ₫ total
includes taxes & fees
13 Dec - 14 Dec
Hotel Fernando III
Lobby sitting area
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4.0 star property
Historical Center
9.6 out of 10, Exceptional, (1078)
"A great spot with a wonderful staff and breakfast"
Canada
Don
The price is 3.415.395 ₫
3.756.935 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Amadeus Sevilla
Porch
Hotel Boutique Palacio Pinello

Hotel Boutique Palacio Pinello

4.0 star property
Historical Center
9.4 out of 10, Exceptional, (680)
"The hotel is centric"
United States
javier
The price is 2.347.722 ₫
2.582.494 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Hotel Boutique Palacio Pinello
Junior Suite | Minibar, in-room safe, desk, laptop workspace
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4.0 star property
Historical Center
9.6 out of 10, Exceptional, (1111)
"Thoroughly enjoyed our stay and would highly recommend. Staff were very friendly and helpful and the breakfast very tasty! "
United Kingdom
John
The price is 9.208.173 ₫
10.128.990 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hotel Rey Alfonso X
Breakfast buffet
U-Sense Sevilla Centro

U-Sense Sevilla Centro

3.0 star property
Historical Center
9.4 out of 10, Exceptional, (412)
"Nice location and very nice room"
United States
isabella
U-Sense Sevilla Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santa Cruz Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Santa Cruz?
While you're visiting, you might want to think about enjoying the monuments and museums, which Santa Cruz is known for.
What's there to see and do in Santa Cruz?
Take in the sights and attractions that Santa Cruz offers with a visit to Convent of the Incarnation, Giralda Tower and General Archive of the Indies. If you have a little extra time during your trip, you might want to make a stop at Murillo Gardens and Archbishop's Palace.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. Head to Puerta Jerez Tram Stop for metro travel.