Photo by Bill Dillard
Search Hotels by Independent in Southeast Missouri from 1.667.954 ₫
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Top Southeast Missouri Independent Hotels
The Riverview
Cape Girardeau
9.4 out of 10, Exceptional, (464)
"Place was nice and safe"
ryan
The price is 2.539.720 ₫
2.865.159 ₫ total
includes taxes & fees
7 Dec - 8 Dec
The Farmstead Hotel
Caruthersville
8.8 out of 10, Excellent, (460)
"Clean rooms and really comfortable beds!"
Andrea
The price is 2.254.891 ₫
2.564.374 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
8.4 out of 10, Very good, (715)
"Stayed one night. Good rate for the Hotel "
Paul
The price is 1.463.438 ₫
1.667.954 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Century Casino & Hotel Caruthersville
Caruthersville
8.4 out of 10, Very good, (102)
"Room was clean staff was really nice"
Toni
The price is 3.204.319 ₫
3.644.113 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Honeysuckle Inn - Mountain View
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
Joyce
The price is 2.515.720 ₫
2.727.231 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Dexter Inn
Dexter
7.0 out of 10, Good, (332)
"Room was nice and spacious."
Rebecca
The price is 1.708.970 ₫
1.918.968 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
New Orleans Inn Portageville
Portageville
8.0 out of 10, Very good, (724)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
Roger
Echo Bluff State Park
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
William
The price is 4.193.307 ₫
4.433.374 ₫ total
includes taxes & fees
7 Dec - 8 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Top Southeast Missouri Hotel Reviews
Explore a world of travel with Expedia
Search Southeast Missouri Hotel Brands
Areas of Southeast Missouri
Hotels near popular Southeast Missouri Attractions
Choose Your Southeast Missouri Hotel Style
- Cheap Hotels in Southeast Missouri
- Family-Friendly Hotels in Southeast Missouri
- Golf Hotels in Southeast Missouri
- Hotels near Museums in Southeast Missouri
- Hotels with Balcony in Southeast Missouri
- Hotels with Breakfast in Southeast Missouri
- Hotels with Connecting Rooms in Southeast Missouri
- Hotels with Entertainment in Southeast Missouri
- Hotels with Indoor Pools in Southeast Missouri
- Hotels with Laundry Service in Southeast Missouri
- Hotels with Parking in Southeast Missouri
- Hotels with Parking in Southeast Missouri
- Hotels with Pool in Southeast Missouri
- Hotels with Restaurant in Southeast Missouri
- Hotels with Room Service in Southeast Missouri
- Hotels with a Bar in Southeast Missouri
- Hotels with a View in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Mountain Hotels in Southeast Missouri
- Pet-Friendly Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Shopping Hotels in Southeast Missouri
- Spa Hotels in Southeast Missouri
- Sports Hotels in Southeast Missouri
- Wedding Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri