Midtown Travel Guide

St. Louis

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.
A sundae with chocolate ice cream and whipped cream.
A cathedral interior with Gothic architecture, including pointed arches and ribbed vaults.
A Gothic-style cathedral with intricate stonework, pointed arches, and statues.
A highway with multiple lanes, vehicles, and a bridge overhead.

Stay near popular Midtown attractions

A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University during your stay in St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
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Top hotels in Midtown

Element by Marriott St. Louis Midtown

Element by Marriott St. Louis Midtown

3 out of 5
3763 Forest Park Avenue St. Louis MO
The price is 3.531.735 ₫ per night from 30 Aug to 31 Aug
3.531.735 ₫
4.129.623 ₫ total
30 Aug - 31 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (803 reviews)
"The staff was amazing!! Always kind and helpful!!"

Reviewed on 10 Aug 2026

Element by Marriott St. Louis Midtown
Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

3 out of 5
525 S Jefferson Ave St. Louis MO
The price is 3.086.998 ₫ per night from 27 Aug to 28 Aug
3.086.998 ₫
3.671.338 ₫ total
27 Aug - 28 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, a 24-hour fitness centre and parking (surcharge). Our guests praise the breakfast and the ...
7.8/10 Good! (1,004 reviews)
"Pull out beds extremely uncomfortable. Bathroom door needed to be lifted in order to close. Smoke detector light blinked constantly. Main room bedding was fine. Expected more space overall."

Reviewed on 9 Aug 2026

Residence Inn by Marriott St Louis Downtown
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
The price is 3.508.190 ₫ per night from 29 Aug to 30 Aug
3.508.190 ₫
4.137.173 ₫ total
29 Aug - 30 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is 2.401.049 ₫ per night from 30 Aug to 31 Aug
2.401.049 ₫
2.802.935 ₫ total
30 Aug - 31 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
9/10 Wonderful! (3,365 reviews)
"Nice place to stay. Staff was kind and professional, and breakfast at the restaurant was excellent. The pool area was spacious and was indoor/outdoor which the kids enjoyed. The game room was closed for renovations and the rooms had dated furniture that probably needs replaced, but overall we enjoyed ..."

Reviewed on 11 Aug 2026

Clayton Plaza Hotel & Extended Stay
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is 2.613.141 ₫ per night from 8 Sept to 9 Sept
2.613.141 ₫
3.826.154 ₫ total
8 Sept - 9 Sept
includes taxes & fees
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
Hollywood Casino & Hotel St. Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
The price is 2.903.871 ₫ per night from 27 Aug to 28 Aug
2.903.871 ₫
3.397.180 ₫ total
27 Aug - 28 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff ...
Renaissance St. Louis Airport Hotel
See all 1,989 properties in Midtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

An ornate hall with arched ceilings and intricate patterns.
Photo by Terry Eaves
Open Photo by Terry Eaves

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

A modern building with a brick facade, parked cars, and a flower bed with tulips.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Midtown Travel Guide

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