Photo by Michael True

Find hotels in Defiance, MO from 1.842.514 ₫

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Top 10 Defiance hotels and places to stay

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.2 out of 10, Very good, (1011)
"Clean room and staff was great "
The price is 2.240.770 ₫
2.588.221 ₫ total
includes taxes & fees
2 Nov - 3 Nov
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1589)
"We enjoyed our stay!"
The Wildwood Hotel

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
8.0 out of 10, Very good, (1003)
"Very nice place"
The price is 2.293.494 ₫
2.660.178 ₫ total
includes taxes & fees
16 Oct - 17 Oct
Sonesta ES Suites St. Louis - Chesterfield

Baymont by Wyndham Warrenton

2.5 star property
7.4 out of 10, Good, (1004)
"Very friendly staff. Nice place to stay"
The price is 2.253.951 ₫
2.585.849 ₫ total
includes taxes & fees
2 Nov - 3 Nov
Baymont by Wyndham Warrenton

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
7.0 out of 10, Good, (1005)
"Clean room."
The price is 1.581.720 ₫
1.842.514 ₫ total
includes taxes & fees
23 Oct - 24 Oct
Super 8 by Wyndham Eureka/Six Flags Nearby

Best Western Plus St. Louis West-Westport

2.5 star property
8.0 out of 10, Very good, (1005)
"It was a very nice place"
The price is 2.325.128 ₫
2.696.869 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Best Western Plus St. Louis West-Westport

Hollywood Casino & Hotel St. Louis

3.5 star property
8.4 out of 10, Very good, (2160)
"Always our favorite place to stay!"
The price is 2.319.592 ₫
3.087.781 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Hollywood Casino & Hotel St. Louis

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1008)
"Great hotel! "
The price is 2.301.403 ₫
2.714.505 ₫ total
includes taxes & fees
14 Oct - 15 Oct
Sleep Inn & Suites O'Fallon MO - Technology Drive

Days Inn by Wyndham St Peters/St Charles

2.0 star property
6.4 out of 10, (994)
"The carpet felt a little damp but aside from that the room was clean and comfortable. "
The price is 1.770.208 ₫
2.034.854 ₫ total
includes taxes & fees
14 Oct - 15 Oct
Days Inn by Wyndham St Peters/St Charles

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (608)
"Clean and welcoming - great staff"
The price is 3.400.698 ₫
3.871.696 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Best Western Plus Washington Hotel

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
9.4 out of 10, Exceptional, (803)
"The area around the hotel appeared to be safe and well kept. "
The price is 3.564.142 ₫
4.246.612 ₫ total
includes taxes & fees
12 Oct - 13 Oct
Holiday Inn Express & Suites Wentzville St Louis West by IHG

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
9.2 out of 10, Wonderful, (208)
"Loved my stay here "
The price is 3.786.901 ₫
4.392.350 ₫ total
includes taxes & fees
2 Nov - 3 Nov
AC Hotel by Marriott St. Louis Chesterfield

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (794)
"The staff were very nice & the breakfast was enjoyable. The hotel was clean."
The price is 2.504.390 ₫
2.953.929 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Holiday Inn Express St. Louis West - O'Fallon by IHG

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Clean, friendly staff and great amenities"
The price is 2.899.556 ₫
3.361.418 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Drury Plaza Hotel St. Louis St. Charles

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1005)
"And nice hotel at a nice price "
The price is 2.021.702 ₫
2.384.598 ₫ total
includes taxes & fees
26 Oct - 27 Oct
Comfort Inn & Suites St. Louis - O'Fallon

Hampton Inn St. Charles St. Peters

2.5 star property
8.0 out of 10, Very good, (1004)
"All around good hotel"
The price is 2.572.404 ₫
2.956.386 ₫ total
includes taxes & fees
3 Nov - 4 Nov
Hampton Inn St. Charles St. Peters

Super 8 by Wyndham St Charles

2.0 star property
8.0 out of 10, Very good, (1003)
"Was a good stay"
The price is 1.994.285 ₫
2.291.972 ₫ total
includes taxes & fees
16 Oct - 17 Oct
Super 8 by Wyndham St Charles

Elimwood Hotel, a Ramada by Wyndham

3.0 star property
7.4 out of 10, Good, (1005)
"Clean room friendly staff very helpful would definitely stay again "
The price is 2.301.403 ₫
2.669.680 ₫ total
includes taxes & fees
26 Oct - 27 Oct
Elimwood Hotel, a Ramada by Wyndham

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.0 out of 10, Very good, (1040)
"Nice staff "
The price is 2.083.916 ₫
2.406.672 ₫ total
includes taxes & fees
2 Nov - 3 Nov
Wingate by Wyndham St. Louis/Fenton Route 66

La Quinta Inn & Suites by Wyndham St. Louis Westport

3.0 star property
7.2 out of 10, Good, (1063)
"Was a great stay "
The price is 2.372.580 ₫
2.751.907 ₫ total
includes taxes & fees
19 Oct - 20 Oct
La Quinta Inn & Suites by Wyndham St. Louis Westport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

More cheap stays in Defiance

More cheap stays in Defiance

Hotels in Defiance with star rating

Hotels in Defiance with star rating

Frequently asked questions

What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Explore a world of travel with Expedia

Explore a world of travel with Expedia