Find hotels in Defiance, MO from 1.902.238 ₫

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Our top choices for Defiance hotels

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.2 out of 10, Wonderful, (30)
"Super clean , quiet place "
United States
Phoenix
The price is 2.338.386 ₫
2.768.614 ₫ total
includes taxes & fees
9 Jan - 10 Jan
WoodSpring Suites St Peters-OFallon

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1002)
"Great location and friendly staff "
United States
Heather
The price is 2.486.309 ₫
2.857.440 ₫ total
includes taxes & fees
5 Feb - 6 Feb
Hampton Inn St. Charles St. Peters

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (920)
"The staff and breakfast were terrific."
United States
Kevin
The price is 1.942.962 ₫
2.194.575 ₫ total
includes taxes & fees
14 Jan - 15 Jan
Quality Inn Foristell

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1617)
"Clean room, friendly staff and lots of activities in the immediate area."
United States
Anonymous traveller
The Wildwood Hotel

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1002)
"Very good place to stay"
United States
Jasur
The price is 2.057.254 ₫
2.426.531 ₫ total
includes taxes & fees
25 Jan - 26 Jan
Sleep Inn & Suites O'Fallon MO - Technology Drive

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1063)
"Rooms were good qnd clean, beds were comfortable and staff was very nice and accommodating "
United States
Daniel
The price is 2.233.290 ₫
2.579.581 ₫ total
includes taxes & fees
1 Feb - 2 Feb
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1005)
"The menu at breakfast was good. Pillows and bed are great! This is an older hotel. I love staying here. The staff is excellent!"
United States
Glenda
The price is 1.951.370 ₫
2.301.640 ₫ total
includes taxes & fees
24 Jan - 25 Jan
Comfort Inn & Suites St. Louis - O'Fallon

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (856)
"A very nice stay with very pleasant staff"
United States
Clifford
The price is 2.496.030 ₫
2.944.067 ₫ total
includes taxes & fees
11 Jan - 12 Jan
Holiday Inn Express St. Louis West - O'Fallon by IHG

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (640)
"Easy check in accessible room, comfortable bed and chairs"
United States
Maurine
The price is 3.131.861 ₫
3.584.415 ₫ total
includes taxes & fees
23 Jan - 24 Jan
Hampton Inn St. Louis Wentzville

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1002)
"Nice place and nice people "
United States
Columbus
The price is 1.920.629 ₫
2.193.838 ₫ total
includes taxes & fees
21 Jan - 22 Jan
Baymont by Wyndham Warrenton

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (623)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is 1.518.637 ₫
1.734.663 ₫ total
includes taxes & fees
14 Jan - 15 Jan
Super 8 by Wyndham Warrenton

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
Maryland Heights
7.4 out of 10, Good, (1003)
"The room was wonderful I was very impressed. The staff was very friendly and polite."
United States
Karen
The price is 1.872.811 ₫
2.172.235 ₫ total
includes taxes & fees
15 Jan - 16 Jan
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1048)
"Absolutely amazing stay very nice play our family stays there every time very kid friendly"
United States
Matthew
The price is 3.415.357 ₫
3.961.331 ₫ total
includes taxes & fees
13 Jan - 14 Jan
Drury Plaza Hotel St. Louis Chesterfield

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1030)
"Breakfast was very good, with a good variety of options, and great service/upkeep. The only downside was the appearance of the eggs, but they also had good taste."
United States
Stephen
The price is 1.987.628 ₫
2.305.410 ₫ total
includes taxes & fees
1 Feb - 2 Feb
Best Western Plus St. Louis West-Westport

Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (722)
"Easy check in, decent stay. Not quite the cleanest, there were hairs in the bathroom "
United States
Devin
The price is 2.468.180 ₫
2.926.644 ₫ total
includes taxes & fees
23 Jan - 24 Jan
Hilton Garden Inn St. Louis/O'Fallon MO

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1000)
"Great hotel for the money"
United States
Jere
The price is 1.986.314 ₫
2.282.812 ₫ total
includes taxes & fees
11 Jan - 12 Jan
Comfort Suites St Charles - St Louis

Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (882)
"The room was impeccable and the front desk and custodial staff incredibly hospitable."
United States
Scott
The price is 2.388.569 ₫
2.734.314 ₫ total
includes taxes & fees
30 Jan - 31 Jan
Comfort Inn Near Six Flags St. Louis

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (857)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is 2.890.140 ₫
3.468.036 ₫ total
includes taxes & fees
18 Jan - 19 Jan
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1000)
"Great hotel! Clean, friendly staff, wonderful amenities!"
United States
Susan
The price is 2.889.877 ₫
3.322.084 ₫ total
includes taxes & fees
15 Jan - 16 Jan
Drury Inn & Suites St. Louis St. Peters

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1135)
"Room was clean, air worked good, staff was super nice."
United States
Jessica
The price is 2.076.960 ₫
2.398.639 ₫ total
includes taxes & fees
11 Jan - 12 Jan
Wingate by Wyndham St. Louis/Fenton Route 66
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Frequently asked questions

What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.