Find hotels in Defiance, MO from 1.906.002 ₫

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Our top choices for Defiance hotels

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,001 reviews)
"The room was clean. The parking was easy."
United States
Chris
The price is 1.947.071 ₫
2.224.041 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Baymont by Wyndham Warrenton

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,195 reviews)
"Everything was great for overnight stay. "
United States
Regina
The price is 2.350.042 ₫
2.714.200 ₫ total
includes taxes & fees
12 Apr - 13 Apr
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (966 reviews)
"Comfy beds, but the trim, doors, and other finishings look pretty rough and in need of replacement. Simple enough breakfast and was just there for a night to sleep so it did the job."
United States
Laura
The price is 2.394.350 ₫
2.704.418 ₫ total
includes taxes & fees
14 Apr - 15 Apr
Quality Inn Foristell

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (688 reviews)
"Very pet friendly. "
United States
Sara
The price is 3.561.118 ₫
4.075.699 ₫ total
includes taxes & fees
29 Apr - 30 Apr
Hampton Inn St. Louis Wentzville

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.2 out of 10, Wonderful, (400 reviews)
"Kelly & the other staff were wonderful. You breakfast options are great!"
United States
Cynthia
The price is 3.001.734 ₫
3.612.350 ₫ total
includes taxes & fees
3 May - 4 May
Holiday Inn Express & Suites St Peters by IHG

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (640 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is 1.387.644 ₫
1.585.037 ₫ total
includes taxes & fees
22 Apr - 23 Apr
Super 8 by Wyndham Warrenton

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,192 reviews)
"Great location, comfy and clean rooms "
United States
Nestor
The price is 2.237.710 ₫
2.584.687 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Wingate by Wyndham St. Louis/Fenton Route 66

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.8 out of 10, Excellent, (76 reviews)
"Nice hotel with good staff."
United States
Michael
The price is 2.343.014 ₫
2.774.093 ₫ total
includes taxes & fees
13 Apr - 14 Apr
WoodSpring Suites St Peters-OFallon

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,013 reviews)
"Very clean place with great food and friendly staff. "
Canada
Kara
The price is 2.922.478 ₫
3.418.949 ₫ total
includes taxes & fees
3 May - 4 May
Drury Inn & Suites Southwest St. Louis

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (672 reviews)
"Great stay and accommodations. The pool was very nice. "
United States
Shane
The price is 3.396.054 ₫
3.866.408 ₫ total
includes taxes & fees
22 Apr - 23 Apr
Best Western Plus Washington Hotel

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,001 reviews)
"This was one of our best stays ever nice hot breakfast. Clean room nice staff will stay again "
United States
Lavania
The price is 2.160.838 ₫
2.548.708 ₫ total
includes taxes & fees
14 Apr - 15 Apr
Sleep Inn & Suites O'Fallon MO - Technology Drive

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,002 reviews)
"Good spot and great location to visit with family "
United States
Ernest
The price is 2.077.253 ₫
2.450.120 ₫ total
includes taxes & fees
6 May - 7 May
Comfort Inn & Suites St. Louis - O'Fallon

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (258 reviews)
"Easy parking, friendly staff, clean and comfy rooms. "
United States
Jan
The price is 2.588.601 ₫
2.989.523 ₫ total
includes taxes & fees
14 Apr - 15 Apr
Best Western Plus Fenton

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,005 reviews)
"Everything was great as always at this location as i have stayed here many times"
United States
Gregory
The price is 3.000.637 ₫
3.448.542 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn St. Charles St. Peters

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (891 reviews)
"Great location, clean, modern, killer shower and good bed! I would definitely recommend!"
United States
John
The price is 3.660.009 ₫
4.357.135 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very good, (1,001 reviews)
"Hotel was clean. Located in a good area, would stay here again. "
United States
Christy
The price is 2.215.754 ₫
2.546.500 ₫ total
includes taxes & fees
26 Apr - 27 Apr
Super 8 by Wyndham St Charles

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (669 reviews)
"Property was nice, easy check-in, nice breakfast, room was clean."
United States
Doris
The price is 3.366.569 ₫
3.853.039 ₫ total
includes taxes & fees
27 Apr - 28 Apr
Fairfield Inn & Suites Wentzville

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,629 reviews)
"Staff was wonderful, location is great for our needs, and it was a quiet stay-which we loved. "
United States
Jessica
The price is 2.321.953 ₫
2.704.797 ₫ total
includes taxes & fees
13 Apr - 14 Apr
The Wildwood Hotel

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,012 reviews)
"Great stay! Very clean and staff was very nice. Definitely will be staying there on my return visit to the area!"
United States
Roxanne
The price is 3.133.126 ₫
3.601.529 ₫ total
includes taxes & fees
27 Apr - 28 Apr
Drury Inn & Suites St. Louis St. Peters

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.8 out of 10, Exceptional, (1,131 reviews)
"It’s a great place very happy!"
United States
Chris
The price is 3.580.073 ₫
4.152.455 ₫ total
includes taxes & fees
19 Apr - 20 Apr
Drury Plaza Hotel St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

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Frequently asked questions

What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.