Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Bella Vista
2 out of top 10 points of interest in this area
Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.
El Cangrejo
The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Luxor Towers might round out your trip.
San Francisco
1 out of top 10 points of interest in this area
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
Punta Paitilla
Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.
Top hotels in Santa Ana
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
1.760.062 ₫
2.718.318 ₫ total
18 Aug - 19 Aug
includes taxes & fees
9/10 Wonderful! (104 reviews)
"The apartment was beautifully decorated, modern, and clean. The staff are friendly, extremely resourceful, and caring. They went above and beyond to ensure my deliveries, including prescriptions and food, were received. The staff also referred me to a wonderful Logistics Manager who drove and accompanied ..."
Reviewed on 12 Aug 2026
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
3.589.001 ₫
3.947.901 ₫ total
13 Sept - 14 Sept
includes taxes & fees
9/10 Wonderful! (5,802 reviews)
"RIu hotel is excellent, they have great rooms, the location is good, breakfast was very good. My only complain and reason for not getting full excellent rating is that the tv set was old and the images ere blurry."
Reviewed on 13 Aug 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
3.289.860 ₫
3.791.172 ₫ total
12 Sept - 13 Sept
includes taxes & fees
8.6/10 Excellent! (2,671 reviews)
"This was the first at stay in many that we were on the first floor and close to the lobby. I definitely prefer being in two or three or higher to separate us from the lobby and pool a little more. The Crowne is definitely our go-to place for overnight between flights at PTY. Great staff and timely ..."
Reviewed on 13 Aug 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Ana holiday package cost?
From as little as . Yes, you read that correctly. Our Santa Ana holiday packages are an easy way to stretch your budget further. Combine your favourite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1null000null000 hotels throughout the world, which lets you customize your Santa Ana holiday.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favourites among lots of travellers.
How far in advance should I book my Santa Ana holiday?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia holiday package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana holiday package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana holiday package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.
Stay near popular Santa Ana attractions
El Machetazo Santa Ana
You can browse for the perfect souvenirs at El Machetazo Santa Ana during your visit to Panama City. Amble around the area's parks or visit its shops.