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24 Dec - 25 Dec
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25 Dec - 26 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Santo Spirito Hospital hotels

Property entrance
San Pietro Boutique Rooms

San Pietro Boutique Rooms

San Pietro Boutique Rooms
Prati, 0.6 km from Santo Spirito Hospital
10.0 out of 10, Exceptional, (915)
"Great place to stay in Rome. Quiet and less crowded. "
United States
Tanya
San Pietro Boutique Rooms
Panoramic Studio Suite, Terrace | Minibar, in-room safe, individually decorated, individually furnished
Passpartout Boutique Palace

Passpartout Boutique Palace

Passpartout Boutique Palace
0.4 km from Santo Spirito Hospital
9.8 out of 10, Exceptional, (246)
"Excellent location, great dining options nearby, modern boutique hotel."
Canada
Matthew
The price is 3.295.999 ₫
4.060.463 ₫ total
includes taxes & fees
13 Jan - 14 Jan 2026
Passpartout Boutique Palace
Free daily continental breakfast
B&B Roma Borgo 91

B&B Roma Borgo 91

B&B Roma Borgo 91
0.5 km from Santo Spirito Hospital
9.8 out of 10, Exceptional, (63)
"Was very clean and wonderful. very much enjoyed our time there."
United States
Joseph
The price is 5.845.246 ₫
6.802.510 ₫ total
includes taxes & fees
23 Jan - 24 Jan 2026
B&B Roma Borgo 91
Standard Double Room | Premium bedding, free minibar, in-room safe, desk
Corso Vittorio 308

Corso Vittorio 308

Corso Vittorio 308
0.3 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (63)
"The staff and property made for a 5 star stay."
United States
Brady
Corso Vittorio 308
Panoramic Triple Room | In-room safe, desk, soundproofing, iron/ironing board
Charme 308

Charme 308

Charme 308
0.3 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (95)
"Great location! The room was spotless. We loved everything about this place."
United States
Heather
The price is 3.761.289 ₫
4.572.282 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Charme 308
Lobby
Navona Street Hotel

Navona Street Hotel

Navona Street Hotel
3.0 star property
0.4 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (269)
"Staff was very friendly and helpful. "
United States
Eli M
The price is 4.160.070 ₫
4.948.817 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Navona Street Hotel
Classic Quadruple Room | Hypo-allergenic bedding, minibar, in-room safe, desk
Hotel Sant' Anna

Hotel Sant' Anna

Hotel Sant' Anna
3.0 star property
0.4 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (323)
"Wonderful location, very helpful service and staff!"
United States
Stephen
Hotel Sant' Anna
Junior Suite | Desk, laptop workspace, soundproofing, free WiFi
Porta Castello Suites

Porta Castello Suites

Porta Castello Suites
0.5 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (181)
"Staff were extremely helpful and the room was amazing"
Australia
Daniel James
The price is 4.352.422 ₫
5.222.529 ₫ total
includes taxes & fees
23 Jan - 24 Jan 2026
Porta Castello Suites
Junior Suite, Balcony | Balcony
Passepartout

Passepartout

Passepartout
Parione, 0.6 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (288)
"Kind and helpful and in a great place. It was in the best spot to see every thing I wanted. Perfect for walking to grocery and shopping and restaurants "
United States
Catriona
Passepartout
Lobby sitting area
Le Suite Del Barone

Le Suite Del Barone

Le Suite Del Barone
0.6 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (417)
"We enjoyed our stay very much. "
Germany
Ulrike
The price is 3.195.294 ₫
3.949.687 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Le Suite Del Barone
Classic Double Room | Hypo-allergenic bedding, minibar, soundproofing, iron/ironing board
Vatican Jubilee

Vatican Jubilee

Vatican Jubilee
Prati, 0.6 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (58)
"Great place!"
United States
Hugo
The price is 1.967.633 ₫
2.536.156 ₫ total
includes taxes & fees
19 Jan - 20 Jan 2026
Vatican Jubilee
Free daily buffet breakfast
Domus Giulia

Domus Giulia

Domus Giulia
0.2 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (140)
"Very nice place next to some great attractions, thank you!"
Canada
Benjamin
Domus Giulia
View from property
Palazzo Medusa

Palazzo Medusa

Palazzo Medusa
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (287)
"Great location, friendly and helpful staff, spotless room - I highly recommend!!!"
United Kingdom
James
The price is 2.756.415 ₫
3.342.673 ₫ total
includes taxes & fees
20 Jan - 21 Jan 2026
Palazzo Medusa
Deluxe Double Room, River View (Breakfast at Navona Street Hotel) | View from room
B&B Rome River Inn

B&B Rome River Inn

B&B Rome River Inn
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (506)
"Staff very helpful Good location Enjoyed stay"
Australia
Richard
The price is 3.915.952 ₫
4.680.287 ₫ total
includes taxes & fees
16 Jan - 17 Jan 2026
B&B Rome River Inn
1 bedroom, premium bedding, in-room safe, desk
Capricci Romani

Capricci Romani

Capricci Romani
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (361)
"Really enjoyed the location and staff. Breakfast was amazing. "
United States
Raquel
Capricci Romani
Quadruple Room | Select Comfort beds, in-room safe, desk, blackout curtains
B&B At Your Place

B&B At Your Place

B&B At Your Place
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (421)
"The location was superb. It was very near the Vatican and other tourist places. Luca arranged for our pick up and drop off at the airport. We had fresh towels everyday and croissants, coffee and tea was available everyday."
Canada
Kristina
B&B At Your Place
Superior Double Room, 1 Double Bed | View from room
La Maison dell'Orologio

La Maison dell'Orologio

La Maison dell'Orologio
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (255)
"Room was cleaned well"
United States
Augusta
La Maison dell'Orologio
Staircase
All’Orologio

All’Orologio

All’Orologio
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (169)
"Very happy with my choice… staff were excellent communicators before and during my stay, loved the location. "
Canada
Andrew
All’Orologio
Aerial view
Navona Queen Rooftop

Navona Queen Rooftop

Navona Queen Rooftop
0.5 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (370)
"The staff was wonderful, everything was spotless, bed was comfortable, and the view from the rooftop was great!"
United States
Anne
Navona Queen Rooftop
Suite | Premium bedding, down duvets, in-room safe, desk
The Pope's Window

The Pope's Window

The Pope's Window
0.6 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (412)
"The room was great except you can hear the pkumbing from the other rooms but nothing too bothersome it was very clean and very close to the St. Peters Basilica. A less than 5 min walk."
United States
Zuzell
The price is 2.934.454 ₫
3.599.659 ₫ total
includes taxes & fees
25 Dec - 26 Dec
The Pope's Window
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santo Spirito Hospital Hotel Reviews

Hotels near other Santo Spirito Hospital attractions

Vittorio Emanuele II Bridge

You can learn about the history of Rome when you stop by Vittorio Emanuele II Bridge. Discover the acclaimed theatre scene and notable monuments in this vibrant area.
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Accademia di Storia dell‘Arte Sanitaria

You can study the exhibits at Accademia di Storia dell‘Arte Sanitaria, a museum with a story of its own, during your trip to Rome. Amble around this vibrant area's riverfront or experience its fascinating museums.
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Frequently asked questions

What's the area like around Santo Spirito Hospital?
Santo Spirito Hospital is located in a historic area of Rome known for its stunning cathedral and notable monuments. If you're looking for a convenient place to stay, take a look at the 2032 hotels and other accommodation options you'll find within a mile.
How many hotels can I expect to find close to Santo Spirito Hospital?
Expedia has 2032 hotels and other accommodation options within a mile from Santo Spirito Hospital.
If I need to cancel the hotel reservation for my stay near Santo Spirito Hospital, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view the top deals on offer near Santo Spirito Hospital.
What can I see and do near Santo Spirito Hospital?
You might want to spend some time browsing the exhibits at Vatican Museums, Castel Sant'Angelo or Cloister of Bramante. Piazza Navona, Trevi Fountain and Colosseum are well-known local landmarks worth a visit. You can check out the local talent at Auditorium Conciliazione, Paul VI Audience Hall and Sistina Theater.
How can I get to Santo Spirito Hospital?
With so many transport options, seeing the area around Santo Spirito Hospital is a breeze. Take advantage of metro transport at Venezia Tram Stop, Arenula-Cairoli Tram Station and Barberini Station. If you want to journey outside of the area, hop aboard a train from Rome Piazzale Flaminio Station, Rome Termini Station or Rome (XRJ-Termini Rail Station).