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Check availability on Colon 4 Star Hotels

Our top choices for Colon 4-star hotels

Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very good, (1278)
"Clean rooms, staff was amazing!!"
United States
Christopher
The price is 3.218.635 ₫
3.540.578 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Megapolis Hotel Panamá
View from property
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1015)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is 4.604.331 ₫
5.064.738 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Las Americas Golden Tower Panama
Outdoor pool, open 7:00 AM to 8:00 PM, pool umbrellas
Marriott Panama Hotel

Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
Panama City
9.0 out of 10, Wonderful, (1004)
"Great hotel and staff!"
United States
Catherine
The price is 3.731.427 ₫
4.104.570 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Marriott Panama Hotel
Exterior
Novotel Panama City

Novotel Panama City

Novotel Panama City
4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1023)
"Great service, big room, solid breakfasts.. all at good price."
Canada
Nicholas
The price is 2.724.534 ₫
2.996.987 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Novotel Panama City
Restaurant
Studio Coliving

Studio Coliving

Studio Coliving
4.5 star property
Bella Vista
7.8 out of 10, Good, (586)
"Staff very helpful "
United States
Jean
Studio Coliving
Front of property
Decapolis Hotel Panama City

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
San Francisco
8.6 out of 10, Excellent, (1451)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is 3.018.407 ₫
3.320.248 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Decapolis Hotel Panama City
Breakfast, lunch, dinner served; international cuisine
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1121)
"Super confortable, clean, Nice personnel!! Love our stay "
United States
Emelyn
The price is 2.864.051 ₫
3.150.456 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Breakfast, lunch served; local and international cuisine, garden views
American Trade Hotel

American Trade Hotel

American Trade Hotel
4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (607)
"Excellent service and great rooms on a beautiful and historical building"
Canada
Manuel
The price is 7.676.078 ₫
8.443.686 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
American Trade Hotel
Daily buffet breakfast (PAB 21 per person)
Sheraton Grand Panama

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (993)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is 3.333.935 ₫
3.667.329 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Sheraton Grand Panama
Outdoor pool
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
Bella Vista
9.0 out of 10, Wonderful, (626)
"Very great hotel and service "
United States
Prakash
The price is 1.930.339 ₫
2.866.554 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Waymore Hotel Spa & Casino
Food and drink
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1006)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
The price is 2.662.673 ₫
2.928.940 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott Panama Metromall
Outdoor pool
Holiday Inn Panama Distrito Financiero by IHG

Holiday Inn Panama Distrito Financiero by IHG

Holiday Inn Panama Distrito Financiero by IHG
4.0 star property
Bella Vista
8.8 out of 10, Excellent, (1004)
"Clean room , friendly staff "
United States
Junique
The price is 2.105.920 ₫
2.461.294 ₫ total
includes taxes & fees
16 Jan - 17 Jan 2026
Holiday Inn Panama Distrito Financiero by IHG
Front of property
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1005)
"Excellent hotel , good breakfast, great location, would highly recommend "
United States
Glen
The price is 6.853.951 ₫
7.539.346 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Central Hotel Panama Casco Viejo
Exterior
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"Staff was very helpful. Great location."
United States
John
The price is 2.438.919 ₫
2.682.811 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Courtyard by Marriott Panama Multiplaza Mall
Outdoor pool, open 6:00 AM to 11:00 PM, pool umbrellas, pool loungers
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (538)
"It's location is close to everything. "
United States
Sharon
The price is 4.006.262 ₫
4.406.888 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Residence Inn by Marriott Panama City
Lobby
Hyatt Regency Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (125)
"Great hotel fair price"
United States
Santiago
The price is 3.553.740 ₫
3.909.114 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Hyatt Regency Panama City
Terrace/patio
Hotel San Felipe

Hotel San Felipe

Hotel San Felipe
4.0 star property
Casco Viejo
9.4 out of 10, Exceptional, (249)
"Nice hotel, perfect area in the old quarter. Clean, comfortable, great staff. Highly recommend!"
Canada
Neil
The price is 3.070.432 ₫
3.377.475 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel San Felipe
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is 8.482.532 ₫
9.330.785 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hotel La Compañía Casco Antiguo
Garden
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador
8.4 out of 10, Very good, (1003)
"Wonderful staff and easy checkin!"
United States
Kristin
The price is 2.192.789 ₫
2.412.068 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Radisson Hotel Panama Canal
Beach/ocean view
Radisson Colon 2,000 Hotel & Casino

Radisson Colon 2,000 Hotel & Casino

Radisson Colon 2,000 Hotel & Casino
4.0 star property
Barrio Sur
8.2 out of 10, Very good, (824)
"Staff was great room was clean"
United States
Bridgett
The price is 2.378.900 ₫
2.616.790 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Radisson Colon 2,000 Hotel & Casino
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Colon.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
The price is 3.012.457 ₫ per night from 20 Dec to 21 Dec
3.012.457 ₫
3.313.703 ₫ total
20 Dec - 21 Dec
includes taxes & fees
9/10 Wonderful! (4,668 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Colon

Explore the colourful Zona Libre free trade zone for duty-free shopping and visit the historic Colon 2000 cruise port. Discover Panama's colonial history at Fort San Lorenzo, located on the Caribbean coast outside the city.

See all hotels in Colon
Adobe

Top Colon Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Colon?
If you're looking for upscale comfort and loads of amenities on your Colon getaway, check out Radisson Colon 2,000 Hotel & Casino. This popular 4-star hotel offers proposal/romance packages and premium bedding. Melia Panama Canal also gets top reviews from Expedia customers. A terrace and a swimming pool are among its conveniences.
How much does it cost to stay in a 4-star hotel in Colon?
To lock in a 4-star hotel in Colon that's within your budget, take advantage of Expedia's filter tool. Take a look at what's available during your preferred dates and use our pricing filter to set your maximum rate. You can also list your results by the cheapest escape first.

  • Search for the lowest price from 3.313.703 ₫

What's the difference between 5-star and 4-star hotels in Colon?
Offering a welcoming traveller experience and upscale décor, 4-star hotels are a fantastic option for your Colon holiday. These types of stays generally feature lots of handy amenities that make it simple to unpack and recharge — think pillowtop mattresses, gyms and restaurants. Or live in the lap of luxury at a 5-star hotel designed to spoil you with luxury perks and amenities. On-site health clubs, complimentary toiletries and gourmet dining are typically featured at these swanky retreats.