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Our top choices for Lake Nona Medical City hotels

Exterior
Aloft Orlando Lake Nona

Aloft Orlando Lake Nona

Aloft Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.8 out of 10, Exceptional, (271)
"Great staff and nice amenities. "
United States
David
The price is 3.109.117 ₫
3.497.756 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Aloft Orlando Lake Nona
Outdoor pool
Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (593)
"Great stay"
United States
Romulo
The price is 3.920.935 ₫
4.455.392 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Courtyard Orlando Lake Nona
Outdoor pool
Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (326)
"Very clean hotel and spacious room with comfortable seating and kitchen area. The location was great for me as I was there visiting someone in an area hospital. There are also restaurants and coffee shops right outside the entrance. "
United States
Sharon
The price is 4.184.085 ₫
4.754.200 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Residence Inn Orlando Lake Nona
Reception
Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks
3.0 star property
30.8 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2031)
"Very nice place to stay in, we love it!!"
United States
Basim
The price is 1.293.119 ₫
2.512.754 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Kompose Boutique Resort at Theme Parks
Reception
Seasons Florida Resort

Seasons Florida Resort

Seasons Florida Resort
2.0 star property
19.8 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3299)
"Excellent location and value, very clean and friendly check in"
United States
Jason
The price is 2.131.515 ₫
2.419.270 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Seasons Florida Resort
Restaurant
Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3728)
"Beautiful property, excellent staff and love the shuttle service to the airport!"
United States
Robert
The price is 2.107.831 ₫
2.371.310 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Wingate by Wyndham - Orlando International Airport
Lobby
Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
Airport North, 11 km from Lake Nona Medical City
7.8 out of 10, Good, (4318)
"Always enjoy my stay here. "
United States
David
The price is 2.252.183 ₫
2.533.706 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Country Inn & Suites by Radisson, Orlando Airport, FL
Exterior
La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (881)
"nice and clean staff was great also"
United States
sumatran
The price is 2.505.188 ₫
2.818.336 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
La Quinta Inn & Suites by Wyndham Orlando Airport North
Outdoor banquet area
Rosen Shingle Creek

Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
16.9 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4367)
"Room, facilities and staff were great. "
United States
Gary E
The price is 3.557.788 ₫
4.002.512 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Rosen Shingle Creek
Exterior
Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village
3.0 star property
Airport North, 10.6 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2457)
"Great stay "
United States
Nancy
The price is 2.567.818 ₫
2.888.796 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Hampton Inn & Suites Orlando Airport @ Gateway Village
Lobby
Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
11.1 km from Lake Nona Medical City
8.8 out of 10, Excellent, (1933)
"Clean room and pleasant staff. "
United States
Mariama Velinique
The price is 2.394.672 ₫
2.694.005 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Cambria Hotel Orlando Airport
Lobby
Hyatt House Orlando International Drive

Hyatt House Orlando International Drive

Hyatt House Orlando International Drive
4.0 star property
International Drive District, 20.2 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (1381)
"The staff was really friendly and the property was nice and cozy "
United States
curtis
The price is 3.105.170 ₫
3.493.316 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hyatt House Orlando International Drive
Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility/Hearing Accessible) | Premium bedding, in-room safe, desk, blackout curtains
Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport
3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (5216)
"Excellent place"
United States
Leonard
The price is 2.581.501 ₫
2.904.189 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Ramada by Wyndham Suites Orlando Airport
Fitness facility
Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport
3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (4037)
"Very clean hotel and easy experience checking in and out "
United States
Arielle
The price is 2.510.451 ₫
2.824.257 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Wyndham Garden Orlando Airport
Property amenity
DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel

DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel
3.0 star property
International Drive District, 21.3 km from Lake Nona Medical City
8.6 out of 10, Excellent, (715)
"What a wonderful stay! "
United States
Lucia
The price is 1.990.730 ₫
2.239.570 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
DASKK Orlando Hotel near Universal Blvd, an Ascend Collection Hotel
Exterior
avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG
2.5 star property
11.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2018)
"Easy check in, great people service, clean room, great location. "
United States
Tiffany
The price is 2.894.650 ₫
3.256.481 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
avid hotel Orlando International Airport by IHG
Interior detail
Holiday Inn Orlando International Airport by IHG

Holiday Inn Orlando International Airport by IHG

Holiday Inn Orlando International Airport by IHG
3.5 star property
Airport North, 10.8 km from Lake Nona Medical City
8.6 out of 10, Excellent, (1282)
"Clean room, friendly staff"
United States
Joyce
The price is 2.394.665 ₫
2.693.997 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Holiday Inn Orlando International Airport by IHG
Business centre
Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal
2.5 star property
Florida Center, 22.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (455)
"The rooms and breakfast were lovely"
United States
MacKenzie Rose
The price is 2.255.985 ₫
2.537.984 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Spark by Hilton Orlando near Universal
Courtyard
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
Florida Center, 21.7 km from Lake Nona Medical City
8.4 out of 10, Very good, (6892)
"Great hotel great food"
United States
Malika
The price is 2.568.696 ₫
2.889.784 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
DoubleTree by Hilton at the Entrance to Universal Orlando
Free daily buffet breakfast
Hampton Inn Orlando-International Airport

Hampton Inn Orlando-International Airport

Hampton Inn Orlando-International Airport
2.5 star property
Airport North, 10.8 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (1741)
"clean room, great location for restaurants and taking walks around the small lake."
United States
Walter
The price is 2.352.035 ₫
2.646.038 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Hampton Inn Orlando-International Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.

International Drive District

Visitors to International Drive District rave about its breathtaking beach views, exciting theme parks and popular shops. You might also want to make some time to see Pointe Orlando or Aquatica while you're exploring the neighbourhood.

Magic Kingdom® Theme Park showing interior views and rides as well as a couple
Photo by ©Disney
Open Photo by ©Disney

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Universal Studios Florida® featuring night scenes, a city and signage

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Downtown Orlando

Ample dining options, great live music, and fantastic lake views are just a few top things to explore in Downtown Orlando. A visit to The Social or Orlando City Hall might round out your trip, and you can jump aboard the metro at Church Street Station or Lynx Central Station to get around town.

Top Lake Nona Medical City Hotel Reviews

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.