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Top Trending Hotels Near Lake Nona Medical City, Orlando

Lounge
Aloft Orlando Lake Nona

Aloft Orlando Lake Nona

3.0 star property
Lake Nona Medical City
9.8 out of 10, Exceptional, (257)
"Beautiful hotel and excellent location. "
United States
Samue
The price is 3.005.382 ₫
3.381.055 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Aloft Orlando Lake Nona
Outdoor pool
Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona

3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (590)
"Great stay"
United States
Romulo
The price is 3.796.272 ₫
4.313.514 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Courtyard Orlando Lake Nona
Outdoor pool
Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona

3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (324)
"Good hotel "
China
lily
The price is 4.481.710 ₫
5.092.277 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Residence Inn Orlando Lake Nona
Free daily continental breakfast
La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North

3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (798)
"Near the beach , very nice people at the reception. "
United States
Leonie
The price is 2.087.950 ₫
2.348.944 ₫ total
includes taxes & fees
8 Dec - 9 Dec
La Quinta Inn & Suites by Wyndham Orlando Airport North
Outdoor pool, pool loungers
Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport

3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (3991)
"Would stay again! "
United States
Matthew
The price is 2.214.492 ₫
2.491.304 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Wyndham Garden Orlando Airport
Property grounds
Seasons Florida Resort

Seasons Florida Resort

2.0 star property
19.8 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3281)
"Friendly staff, clean, nice area."
United States
Kevin
The price is 1.601.552 ₫
1.817.763 ₫ total
includes taxes & fees
8 Dec - 9 Dec
Seasons Florida Resort
Exterior
Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village

3.0 star property
Airport North, 10.6 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2439)
"Great location to airport and food choices. "
United States
Aliza
The price is 2.615.210 ₫
2.942.111 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Hampton Inn & Suites Orlando Airport @ Gateway Village
Premium bedding, in-room safe, desk, blackout curtains
Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport

3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (5166)
"Great place to stay close to airport "
United States
Rebekah
The price is 2.352.898 ₫
2.647.010 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Ramada by Wyndham Suites Orlando Airport
Outdoor pool
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

4.0 star property
Florida Center, 21.7 km from Lake Nona Medical City
8.4 out of 10, Very good, (6877)
"Wonderful stay. Great location!"
United States
Charmaine
The price is 2.356.325 ₫
2.650.866 ₫ total
includes taxes & fees
15 Dec - 16 Dec
DoubleTree by Hilton at the Entrance to Universal Orlando
Royal Room, 2 Queen Beds, Pool View | Pool | Outdoor pool, a heated pool, open 9 AM to 9:00 PM, free pool cabanas
Magic Moment Resort & Kids Club, Dazzler Select by Wyndham

Magic Moment Resort & Kids Club, Dazzler Select by Wyndham

3.0 star property
21.6 km from Lake Nona Medical City
8.4 out of 10, Very good, (2689)
"The customer service is exceptional, the atmosphere to get the kids going in the mornings is amazing, great coffee, overall great stay with great price."
United States
Ani
The price is 1.044.962 ₫
2.083.429 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Magic Moment Resort & Kids Club, Dazzler Select by Wyndham
2 outdoor pools, a heated pool, pool cabanas (surcharge), pool umbrellas
Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 star property
Florida Center, 22.2 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (5684)
"Great stay!"
Canada
Catherine
The price is 3.506.279 ₫
3.944.564 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Universal's Cabana Bay Beach Resort
Business centre
Spark by Hilton Orlando near Universal

Spark by Hilton Orlando near Universal

2.5 star property
Florida Center, 22.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (403)
"Wonderful staff great location to universal parks. "
United States
Desire
The price is 2.087.950 ₫
2.348.944 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Spark by Hilton Orlando near Universal
6 outdoor pools, free pool cabanas, pool umbrellas
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4.0 star property
22.5 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4044)
"Very clean best resort "
United States
Shatira
The price is 2.931.566 ₫
3.298.011 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
In-room safe, laptop workspace, blackout curtains, iron/ironing board
Palazzo Lakeside Hotel

Palazzo Lakeside Hotel

3.0 star property
20.5 km from Lake Nona Medical City
8.2 out of 10, Very good, (5146)
"Overall good experience would stay again"
United States
Jacquelyn
The price is 873.879 ₫
1.889.250 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Palazzo Lakeside Hotel
Pillow-top beds, in-room safe, desk, blackout curtains
Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport

3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3720)
"Good room, good breakfast and convenient to the airport."
United States
Mark
The price is 2.159.130 ₫
2.428.823 ₫ total
includes taxes & fees
9 Dec - 10 Dec
Wingate by Wyndham - Orlando International Airport
Lobby
Hyatt House Orlando Airport

Hyatt House Orlando Airport

3.5 star property
Airport North, 10.6 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (2766)
"Great stay close to airport and plenty of dining available "
United States
Lonnie
The price is 3.179.378 ₫
3.576.801 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Hyatt House Orlando Airport
4 outdoor pools, open 5:30 AM to midnight, pool cabanas (surcharge)
Rosen Shingle Creek

Rosen Shingle Creek

4.5 star property
16.9 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4324)
"Great resort "
United States
Camille
The price is 2.931.566 ₫
3.298.011 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Rosen Shingle Creek
Exterior
Tru By Hilton Orlando Convention Center Area, FL

Tru By Hilton Orlando Convention Center Area, FL

3.5 star property
International Drive District, 19.8 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (3647)
"Great location clean rooms "
United States
Erika
The price is 2.087.950 ₫
2.348.942 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Tru By Hilton Orlando Convention Center Area, FL
Front of property
Wyndham Lake Buena Vista – Disney Springs® Area

Wyndham Lake Buena Vista – Disney Springs® Area

4.0 star property
23.2 km from Lake Nona Medical City
8.8 out of 10, Excellent, (2772)
"Great location and consistent service, we’ve stayed many times. "
United States
Tracy
The price is 2.733.843 ₫
4.143.276 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Wyndham Lake Buena Vista – Disney Springs® Area
Bar (on property)
SpringHill Suites by Marriott Orlando Theme Parks/Lake Buena Vista

SpringHill Suites by Marriott Orlando Theme Parks/Lake Buena Vista

3.0 star property
21.8 km from Lake Nona Medical City
8.6 out of 10, Excellent, (3446)
"I this hotel is the best place to stay "
United States
Manese
The price is 2.293.581 ₫
2.580.280 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
SpringHill Suites by Marriott Orlando Theme Parks/Lake Buena Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.

International Drive District

Visitors to International Drive District rave about its breathtaking beach views, exciting theme parks and popular shops. You might also want to make some time to see Pointe Orlando or Aquatica while you're exploring the neighbourhood.

Magic Kingdom® Theme Park showing interior views and rides as well as a couple
Photo by ©Disney
Open Photo by ©Disney

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Downtown Orlando

Ample dining options, great live music, and fantastic lake views are just a few top things to explore in Downtown Orlando. A visit to The Social or Orlando City Hall might round out your trip, and you can jump aboard the metro at Church Street Station or Lynx Central Station to get around town.

Universal Studios Florida® featuring night scenes, a city and signage

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Top Lake Nona Medical City Hotel Reviews

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Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.