Search Hotels in Otay Mesa, San Diego

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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,002 reviews)
"The only hotel in otay mesa and overall the service was good"
United States
MARIA
The price is 2.478.312 ₫
2.819.080 ₫ total
includes taxes & fees
3 May - 4 May
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,718 reviews)
"Very clean. Staff was very friendly. Breakfast buffet was very complete and with variety of food."
United States
Eliza
The price is 3.267.524 ₫
3.716.809 ₫ total
includes taxes & fees
3 May - 4 May
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Hampton Inn & Suites Imperial Beach San Diego

Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
13.7 km from Otay Mesa
9.4 out of 10, Exceptional, (1,001 reviews)
"Room was great, very clean. Staff was so friendly and helpful. Other visitors were great conversation over breakfast. Tons of places to eat walking distance and super close to the beach. For the price it was incredible. Will be returning soon. "
United States
Isabel
The price is 3.612.195 ₫
4.124.946 ₫ total
includes taxes & fees
3 May - 4 May
Hampton Inn & Suites Imperial Beach San Diego

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,504 reviews)
"The restaurants were amazing. Food was delicious and fresh. The pool was spacious and loved the poolside service. Plenty of seating options. The beds were very comfortable. Great airport shuttle. Loved the location. Close to harbor walk."
United States
Helene
The price is 4.453.319 ₫
6.451.701 ₫ total
includes taxes & fees
25 May - 26 May
Sheraton San Diego Resort

Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay
2.5 star property
Bay Park, 33.6 km from Otay Mesa
8.2 out of 10, Very good, (375 reviews)
"Great room. Staff was friendly. Easy access to trolley and free parking made getting around super easy. "
United States
Jason
The price is 2.295.699 ₫
2.638.792 ₫ total
includes taxes & fees
10 May - 11 May
Best Western San Diego Pacific Beach/Mission Bay

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,882 reviews)
"This is a great hotel and casino. Very fun and clean atmosphere. No need to venture out for food Restaurants are great!!"
United States
Frances
The price is 2.598.209 ₫
3.174.242 ₫ total
includes taxes & fees
4 May - 5 May
Sycuan Casino Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,622 reviews)
"This hotel is one of a kind. The pool area is stunning. Restaurants are great. Hip, busy scene at the bars and restaurants, yet quiet and cozy in your stylish room. The design of everything is over the top-- it was a treat to stay here. We'll be back."
United States
Kelly
The price is 6.561.399 ₫
7.542.000 ₫ total
includes taxes & fees
4 May - 5 May
Lafayette Hotel & Club

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,259 reviews)
"Basic beach motel. Served its purpose. Its old and dingy but it was quiet and safe. Manager was very nice. "
United States
Karin
The price is 2.966.859 ₫
3.345.133 ₫ total
includes taxes & fees
5 May - 6 May
Ocean Villa Inn

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,264 reviews)
"Nice hotel close to Mexican border. Continental breakfast included. "
United States
Martina
The price is 3.223.254 ₫
3.666.451 ₫ total
includes taxes & fees
10 May - 11 May
Best Western Americana Inn

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,430 reviews)
"Nice and clean. Easy. Thanks. "
United States
Nancy
The price is 5.243.849 ₫
7.420.969 ₫ total
includes taxes & fees
10 May - 11 May
San Diego Mission Bay Resort

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (638 reviews)
"Clean and spacious room. Amazing outdoor pool/jacuzzi with outdoor seating and a nice fire pit. The bartender Mico is THEE BEST! "
United States
Shatera
The price is 4.953.988 ₫
5.459.047 ₫ total
includes taxes & fees
12 May - 13 May
SpringHill Suites by Marriott Chula Vista Eastlake

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,625 reviews)
"The price was cheaper on Expedia than walking in. The staff was nice. The room was clean. More than enough room for parking. I would get a room there again."
United States
Hanna
The price is 2.029.027 ₫
2.311.873 ₫ total
includes taxes & fees
3 May - 4 May
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,211 reviews)
"Over all great stay. Close to the arena which is the best perk! Over all clean and safe. On site security. Shopping and food near by."
United States
Kevin
The price is 2.872.259 ₫
3.301.518 ₫ total
includes taxes & fees
3 May - 4 May
Wyndham Garden San Diego Near SeaWorld

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (3,558 reviews)
"Room was very clean, staff was friendly and location was amazing!!"
United States
Erica
The price is 4.009.305 ₫
4.608.495 ₫ total
includes taxes & fees
12 May - 13 May
Bay Club Hotel & Marina

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
30.8 km from Otay Mesa
8.6 out of 10, Excellent, (3,623 reviews)
"Thank you, me and my family enjoy when we stay here. everything so good."
United States
Cuong An
The price is 2.845.908 ₫
3.271.230 ₫ total
includes taxes & fees
10 May - 11 May
Comfort Inn Sea World Area

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,456 reviews)
"Front desk personnel were very friendly. Check process was smooth and fast. Breakfast was ok, the served Mexican "
United States
Mary
The price is 2.898.346 ₫
3.193.977 ₫ total
includes taxes & fees
25 May - 26 May
Comfort Inn Chula Vista San Diego South

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,595 reviews)
"Property is huge. Just enough parking. Location is really nice. Room was clean but the shutters were a little dusty. Very quiet got a good nights rest. Overall enjoyed the stay. "
United States
Gabriel
The price is 3.896.522 ₫
4.478.879 ₫ total
includes taxes & fees
10 May - 11 May
Best Western Plus Island Palms Hotel & Marina

Ocean Beach Hotel

Ocean Beach Hotel
3.0 star property
Ocean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,330 reviews)
"Location Location Location! Super friendly staff! Love this place! Already booked 2 more trips to stay here again! "
United States
Suzie
The price is 4.741.994 ₫
5.346.598 ₫ total
includes taxes & fees
10 May - 11 May
Ocean Beach Hotel

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
29.9 km from Otay Mesa
8.4 out of 10, Very good, (1,851 reviews)
"Staff are great. Awesome location. Good breakfast, heated pool. Would stay again!"
United States
Kent
The price is 2.527.588 ₫
2.900.455 ₫ total
includes taxes & fees
3 May - 4 May
Best Western Yacht Harbor Hotel

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.8 out of 10, Good, (1,003 reviews)
"My room was perfect in every way. The complimentary breakfast was excellent, plenty of variety and quantity with nice seating. Day’s Inn has a great location for traveling on foot, bus or trolley to many locations. I will stay here again on my next trip. "
United States
Marla
The price is 2.329.428 ₫
2.566.851 ₫ total
includes taxes & fees
4 May - 5 May
Days Inn by Wyndham San Diego-East/El Cajon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach Farmers Market.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.