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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,004 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is 2.745.573 ₫
3.123.089 ₫ total
includes taxes & fees
5 Apr - 6 Apr
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1,675 reviews)
"Great breakfast!"
United States
Susan
The price is 3.128.034 ₫
3.558.139 ₫ total
includes taxes & fees
8 Apr - 9 Apr
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,006 reviews)
"Great stay"
United States
jennifer
The price is 2.865.174 ₫
3.303.362 ₫ total
includes taxes & fees
5 Apr - 6 Apr
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,381 reviews)
"Beautiful resort! Clean, well decorated and sights are stunning - will stay again! "
Canada
Emily
The price is 3.285.750 ₫
4.933.389 ₫ total
includes taxes & fees
1 Apr - 2 Apr
Sheraton San Diego Resort

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,002 reviews)
"Excelente "
Mexico
Julio
The price is 2.010.879 ₫
2.291.295 ₫ total
includes taxes & fees
17 Mar - 18 Mar
Valli Hi Motel

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,790 reviews)
"Great stay! Extremely clean facility, friendly/attentive staff, beautiful location. Can’t wait to stay again!"
United States
Mary
Sycuan Casino Resort

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,652 reviews)
"Great location "
United States
Efren
The price is 2.712.715 ₫
2.983.987 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Best Western Chula Vista/Otay Valley Hotel

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,528 reviews)
"Very trendy hotel. Highly recommend this place "
United States
Patricia
The price is 6.545.214 ₫
7.510.699 ₫ total
includes taxes & fees
19 Mar - 20 Mar
Lafayette Hotel & Club

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,193 reviews)
"The room was spotless and the staff were very helpful and welcoming would definitely stay here again "
United States
Raul
The price is 2.721.915 ₫
3.128.706 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Wyndham Garden San Diego Near SeaWorld

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,758 reviews)
"Nice and clean hotel when visiting the San Diego area! We have stayed here multiple times. Located next to a nice restaurant as well."
United States
Laura
The price is 3.764.155 ₫
4.147.910 ₫ total
includes taxes & fees
29 Mar - 30 Mar
Best Western Plus Marina Gateway Hotel

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (597 reviews)
"Excellent!"
United States
Robert
The price is 4.494.906 ₫
4.953.162 ₫ total
includes taxes & fees
5 Apr - 6 Apr
SpringHill Suites by Marriott Chula Vista Eastlake

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,064 reviews)
"Staff was great and room was great also "
United States
Stanley
The price is 3.574.896 ₫
4.109.163 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Holiday Inn Express San Diego Airport - Old Town by IHG

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,583 reviews)
"Everything & everyone very nice"
United States
Colleen
The price is 1.718.842 ₫
1.894.695 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Motel 6 El Cajon, CA - San Diego

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,058 reviews)
"Great rooms & location"
Canada
Priscilla
The price is 3.999.415 ₫
5.551.874 ₫ total
includes taxes & fees
19 Mar - 20 Mar
Wyndham San Diego Bayside

Old Town Inn

Old Town Inn
2.5 star property
30.1 km from Otay Mesa
9.2 out of 10, Wonderful, (1,810 reviews)
"Clean room, staff friendly and helpful, close to Old Town"
United States
Craig
Old Town Inn

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,732 reviews)
"Great location for the airport stay"
United States
Christopher
The price is 4.603.204 ₫
5.291.153 ₫ total
includes taxes & fees
4 Apr - 5 Apr
Hampton Inn & Suites San Diego Airport Liberty Station

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,234 reviews)
"Great place and service. Will definitely stay there again. "
United States
Maria
The price is 3.105.691 ₫
3.532.724 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Best Western Americana Inn

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,374 reviews)
"Clean room, excellent friendly staff, comfortable beds"
Canada
Shauna
The price is 6.282.354 ₫
8.611.294 ₫ total
includes taxes & fees
5 Apr - 6 Apr
San Diego Mission Bay Resort

TownePlace Suites by Marriott San Diego Airport/Liberty Station

TownePlace Suites by Marriott San Diego Airport/Liberty Station
3.0 star property
29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,006 reviews)
"Excellent place to stay."
United States
Rosario
The price is 4.222.846 ₫
4.853.950 ₫ total
includes taxes & fees
4 Apr - 5 Apr
TownePlace Suites by Marriott San Diego Airport/Liberty Station

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 30.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,371 reviews)
"Great location, clean room, nice atmosphere."
United States
Jon T
The price is 3.909.254 ₫
4.493.492 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.