Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
Why not visit the animals who live at San Diego Zoo and see why this is a popular attraction in San Diego? Stroll along the area's seaside or experience its acclaimed art galleries.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices.
Mission Bay
Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the seaside in this family-friendly area or visit its top-notch restaurants.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Balboa Park
Balboa Park is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Stroll along the area's seaside or simply savour its top-notch restaurants.
SeaWorld
Make time to visit the sea life at SeaWorld, and find out why this is a popular attraction in San Diego. Discover the beautiful sunsets and top-notch restaurants in this walkable area.
Top hotels in Otay Mesa
Hotel del Coronado, Curio Collection by Hilton
Beauty of hotel; delicious food at every dining venue there; helpful staff
Reviewed on 2 Dec 2025
Legacy Resort Hotel & Spa
Wonderful hotel. Very clean, amazing service, and outstanding food at the restaurant.
Reviewed on 29 Nov 2025
Hampton Inn & Suites by Hilton San Diego SeaWorld
Very clean!
Reviewed on 2 Dec 2025
Manchester Grand Hyatt San Diego
It was nice and the bar up top was great
Reviewed on 3 Dec 2025
Hard Rock Hotel San Diego
Room was clean and staffs were courteous.
Reviewed on 4 Dec 2025
The DEXTRO Little Italy, BW Premier Collection
Mostly everything was great but the a/c wall unit was controlled by the wall thermostat but no matter what temp you set it at or even turn it off it runs 24/7, making the room like a refrigerator
Reviewed on 1 Dec 2025
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and The Rady Shell at Jacobs Park, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa Travel Guide
- Places of interest
- Hotels in Otay Mesa by Star Rating
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- Hotels in top San Diego neighborhoods
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- Cross Border Xpress
- San Diego Zoo
- San Diego Convention Center
- Mission Bay
- San Ysidro Border Crossing
- Port of San Diego
- Balboa Park
- Mission Beach
- Naval Base San Diego
- Seaport Village
- Las Americas Premium Outlets
- USS Midway Museum
- University of San Diego
- Naval Base Coronado
- B Street Cruise Ship Terminal
- Sycuan Casino
- Old Town San Diego State Park
- Snapdragon Stadium
- Waterfront Park
- Fashion Valley Mall
- Shelter Island
Choose Your Otay Mesa Hotel Style
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