Otay Mesa Travel Guide

San Diego


Popular places to visit


Top hotels in Otay Mesa

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is 4.011.739 ₫ per night from 12 Oct to 13 Oct
4.011.739 ₫
5.416.054 ₫ total
12 Oct - 13 Oct
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,971 reviews)
"Excellent view of the Bay, cruise ships docked at the hotel front door."

Reviewed on 7 Oct 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is 6.565.383 ₫ per night from 12 Oct to 13 Oct
6.565.383 ₫
9.046.599 ₫ total
12 Oct - 13 Oct
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free Wi-Fi, 6 restaurants and 3 bars/lounges. Our guests praise the pool and the bar in their reviews. ...
9/10 Wonderful! (2,832 reviews)
"Great area to explore"

Reviewed on 2 Oct 2025

Manchester Grand Hyatt San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
The price is 3.142.946 ₫ per night from 20 Oct to 21 Oct
3.142.946 ₫
3.644.089 ₫ total
20 Oct - 21 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (513 reviews)
"Staff are super nice and helpful. The location is close to everything. We definitely going to stay here again."

Reviewed on 6 Oct 2025

The DEXTRO Little Italy, BW Premier Collection
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4 out of 5
830 Sixth Avenue, San Diego, CA
The price is 3.061.209 ₫ per night from 21 Oct to 22 Oct
3.061.209 ₫
3.549.262 ₫ total
21 Oct - 22 Oct
includes taxes & fees
Stay at this 4-star hotel in San Diego. Enjoy free Wi-Fi, 2 bars/lounges and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in ...
8.6/10 Excellent! (1,891 reviews)
"Staff was great location was great"

Reviewed on 7 Oct 2025

Palihotel San Diego Gaslamp Quarter
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the pool and the bar in their ...
8.2/10 Very Good! (2,106 reviews)
"The pool area is very nice and we enjoyed it over the weekend. They have followed the practice of small pillows for the bed, so while bed was not uncomfortable per we, the 3 small pillows made sleeping uncomfortable. Bring your own. Restaurant is okay for bar style foods. I would love to see more ..."

Reviewed on 6 Oct 2025

Handlery Hotel
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 4.727.075 ₫ per night from 31 Oct to 1 Nov
4.727.075 ₫
6.692.382 ₫ total
31 Oct - 1 Nov
includes taxes & fees
Stay at this 4-star hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their ...
8.8/10 Excellent! (2,987 reviews)
"Very clean, easy to move a lot things to do and Tourist Really love it"

Reviewed on 7 Oct 2025

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa

Petco Park showing a statue or sculpture

East Village

Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.

East Village
Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Gaslamp Quarter
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Downtown San Diego

4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Downtown San Diego
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North Park

North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

North Park
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Little Italy

Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.

Little Italy
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Del Cerro

While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.

Del Cerro


Otay Mesa Travel Guide

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