Search Hotels in Otay Mesa West, San Diego

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15 Dec - 16 Dec
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16 Dec - 17 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Otay Mesa West hotels

3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
31.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1633)
"Nice rooms. Great food at all restaurants "
United States
Steve
Sycuan Casino Resort
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 17.2 km from Otay Mesa West
8.6 out of 10, Excellent, (1865)
"Enjoyed my stay"
United States
Brandon
The price is 2.805.642 ₫
4.543.413 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton San Diego Bayfront
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
19.1 km from Otay Mesa West
8.8 out of 10, Excellent, (739)
"Friendly staff and clean rooms. "
Canada
Justine
The price is 2.714.882 ₫
3.147.770 ₫ total
includes taxes & fees
28 Dec - 29 Dec
The DEXTRO Little Italy, BW Premier Collection
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 26.7 km from Otay Mesa West
8.4 out of 10, Very good, (1311)
"great stay! Food was great and my kids loved the pool and location"
United States
ANDREA
The price is 3.095.282 ₫
4.743.791 ₫ total
includes taxes & fees
16 Dec - 17 Dec
San Diego Mission Bay Resort
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
21.4 km from Otay Mesa West
8.2 out of 10, Very good, (3184)
"Great stay! "
United States
Melissa
The price is 2.946.384 ₫
4.333.772 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Sheraton San Diego Resort
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 17.8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1003)
"Great location "
United States
Mohammad
The price is 2.341.323 ₫
3.474.919 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Exterior
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
22.1 km from Otay Mesa West
8.8 out of 10, Excellent, (1559)
"Staff was great, easy check in and great location"
United States
Alysa
The price is 3.009.521 ₫
3.459.294 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Island Palms Hotel & Marina
Free daily buffet breakfast
Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town
2.5 star property
Old Town San Diego, 23.2 km from Otay Mesa West
8.2 out of 10, Very good, (1915)
"Efficient check in, clean rooms and great breakfast."
Canada
Wendy
The price is 2.124.290 ₫
2.441.765 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn San Diego Old Town
Free continental breakfast
Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Fairfield Inn & Suites by Marriott San Diego Pacific Beach
2.5 star property
Pacific Beach, 29.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (801)
"good place to stay"
United States
Sisi
The price is 2.709.621 ₫
3.114.573 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites by Marriott San Diego Pacific Beach
Exterior
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 18.2 km from Otay Mesa West
9.0 out of 10, Wonderful, (2873)
"Great Location....tons of walking from the hotel Front desk were very nice and polite will be coming back for sure "
United States
Carlos
The price is 4.630.032 ₫
6.801.759 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Manchester Grand Hyatt San Diego
3 restaurants, breakfast, lunch, dinner served; Regional cuisine
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
19.2 km from Otay Mesa West
8.4 out of 10, Very good, (6065)
"Always an amazing stay"
United States
Jana
The price is 3.555.391 ₫
4.885.201 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Wyndham San Diego Bayside
Exterior
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
23.5 km from Otay Mesa West
8.8 out of 10, Excellent, (1288)
"Hotel was very clean and the staff was very friendly"
United States
Norma
The price is 2.462.335 ₫
2.830.331 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn San Diego/Mission Valley
Lobby
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
24.8 km from Otay Mesa West
7.4 out of 10, Good, (4114)
"Room was very clean and staff very pleasant "
Canada
Brian
The price is 2.224.257 ₫
2.556.671 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Wyndham Garden San Diego Near SeaWorld
Lobby sitting area
Kings Inn San Diego

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
23.1 km from Otay Mesa West
8.8 out of 10, Excellent, (3575)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is 1.969.474 ₫
2.259.971 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Kings Inn San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 17.9 km from Otay Mesa West
9.2 out of 10, Wonderful, (1949)
"Great hotel"
United States
Farzana
The price is 4.182.813 ₫
6.233.248 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Marriott Marquis San Diego Marina
View from property
The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo
3.0 star property
23.1 km from Otay Mesa West
8.0 out of 10, Very good, (1826)
"Clean and helpful staff, thank you !"
United States
Bora
The Atwood Hotel San Diego - SeaWorld/Zoo
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
18.7 km from Otay Mesa West
8.6 out of 10, Excellent, (1064)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.556.706 ₫
4.886.463 ₫ total
includes taxes & fees
22 Dec - 23 Dec
The Westin San Diego Bayview
3 bars/lounges, lobby lounge, cocktail bar, cocktail bar
Lafayette Hotel & Club

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
21.3 km from Otay Mesa West
9.4 out of 10, Exceptional, (1337)
"My wife loved everything about this vintage hotel."
United States
Eddie
The price is 6.024.303 ₫
6.912.953 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Lafayette Hotel & Club
Premium Room, 1 King Bed, Non Smoking, Ocean View (Non-Pet friendly) | Iron/ironing board, free WiFi, bed sheets
Ocean Villa Inn

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 26.8 km from Otay Mesa West
8.0 out of 10, Very good, (1136)
"Fantastic location!"
United States
Lydia
Ocean Villa Inn
Exterior
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 24.1 km from Otay Mesa West
8.6 out of 10, Excellent, (1294)
"Very nice hotel"
United States
Krist
The price is 3.135.794 ₫
3.604.438 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa West Hotel Reviews

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

10/10 Excellent
"Clean rooms, friendly staff"
Marie 1-night trip
Posted 16 hours ago
Courtyard by Marriott San Diego Downtown Little Italy

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Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.