Search Hotels in Otay Mesa West, San Diego

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17 Dec - 18 Dec
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Our top choices for Otay Mesa West hotels

Reception
Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld
3.0 star property
24.3 km from Otay Mesa West
9.2 out of 10, Wonderful, (413)
"Clean rooms, friendly staff."
United States
KARLA
The price is 2.661.459 ₫
3.059.214 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn & Suites by Hilton San Diego SeaWorld
Exterior
Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
22.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1704)
"Excellent place "
Mexico
Rafael
The price is 4.002.055 ₫
4.600.161 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites San Diego Airport Liberty Station
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Little Italy, 19.2 km from Otay Mesa West
9.0 out of 10, Wonderful, (104)
"It was a nice place to stay at"
United States
Eric
The price is 3.446.872 ₫
3.996.476 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott San Diego Downtown Little Italy
Lobby
Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Fairfield Inn & Suites by Marriott San Diego Pacific Beach
2.5 star property
Pacific Beach, 29.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (801)
"good place to stay"
United States
Sisi
The price is 2.710.136 ₫
3.115.166 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Fairfield Inn & Suites by Marriott San Diego Pacific Beach
Property grounds
The Inn at Sunset Cliffs

The Inn at Sunset Cliffs

The Inn at Sunset Cliffs
2.5 star property
Ocean Beach, 25.8 km from Otay Mesa West
9.2 out of 10, Wonderful, (1000)
"Perfect location, units are clean and comfy. Highly recommend- will definitely be back!"
United States
Jennifer
The price is 5.157.415 ₫
5.814.952 ₫ total
includes taxes & fees
28 Dec - 29 Dec
The Inn at Sunset Cliffs
Desk, blackout curtains, iron/ironing board, cots/infant beds
Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
22.9 km from Otay Mesa West
8.6 out of 10, Excellent, (1643)
"The breakfast options were good and the staff were very helpful."
Canada
Gail or Rob
The price is 2.584.119 ₫
2.965.276 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Best Western Yacht Harbor Hotel
Marina
Sea Harbor Hotel

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
23 km from Otay Mesa West
8.6 out of 10, Excellent, (1005)
"Great stay"
United States
Naomi
Sea Harbor Hotel
Standard Room, 2 Queen Beds | Pillow-top beds, individually decorated, individually furnished, desk
GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 29.3 km from Otay Mesa West
8.0 out of 10, Very good, (1866)
"Courteous staff and clean room. "
United States
Rachel
The price is 2.218.797 ₫
2.550.396 ₫ total
includes taxes & fees
21 Dec - 22 Dec
GreenTree Inn San Diego Mission Bay
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay
3.0 star property
North Pacific Beach, 29.8 km from Otay Mesa West
8.0 out of 10, Very good, (1429)
"Friendly staff, clean room"
United States
Janice
The price is 2.523.847 ₫
2.901.654 ₫ total
includes taxes & fees
19 Dec - 20 Dec
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Lobby
Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
29.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1013)
"It was a very nice stay "
United States
Douglas
The price is 2.678.150 ₫
3.073.177 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn San Diego-Kearny Mesa
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
22.1 km from Otay Mesa West
9.2 out of 10, Wonderful, (3193)
"Great stay and location!"
United States
Jason
The price is 3.247.599 ₫
3.732.953 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Bay Club Hotel & Marina
Lobby
Best Western Plus Bayside Inn

Best Western Plus Bayside Inn

Best Western Plus Bayside Inn
3.0 star property
19.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (1002)
"Great staff and location."
United States
Lisa
The price is 3.218.099 ₫
3.724.949 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Best Western Plus Bayside Inn
View from property
Ocean Beach Hotel

Ocean Beach Hotel

Ocean Beach Hotel
3.0 star property
Ocean Beach, 26.5 km from Otay Mesa West
8.8 out of 10, Excellent, (1273)
"Great location."
United States
Maryna
Ocean Beach Hotel
Desk, laptop workspace, blackout curtains, iron/ironing board
SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach
2.5 star property
Pacific Beach, 29.4 km from Otay Mesa West
8.0 out of 10, Very good, (1414)
"our stay was great and staff was supportive..."
United States
Ramesh
The price is 2.083.647 ₫
2.353.375 ₫ total
includes taxes & fees
24 Dec - 25 Dec
SureStay Hotel by Best Western San Diego Pacific Beach
Theatre show
Homewood Suites by Hilton San Diego Airport/Liberty Station

Homewood Suites by Hilton San Diego Airport/Liberty Station

Homewood Suites by Hilton San Diego Airport/Liberty Station
3.0 star property
22.7 km from Otay Mesa West
9.4 out of 10, Exceptional, (1350)
"Great place to stay at!"
United States
Sandy
The price is 4.164.137 ₫
4.786.468 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Homewood Suites by Hilton San Diego Airport/Liberty Station
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay, 27.1 km from Otay Mesa West
9.0 out of 10, Wonderful, (3929)
"Always love staying here. Staff was very courteous and the rooms very clean. "
United States
Eric
The price is 3.657.368 ₫
4.730.202 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
The Dana on Mission Bay
Front of property
Heritage Inn San Diego

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
25.2 km from Otay Mesa West
7.4 out of 10, Good, (1166)
"Clean room, great location "
United States
Benjamin
The price is 1.581.583 ₫
1.817.951 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Heritage Inn San Diego
Beach nearby, scuba diving
PB Surf Beachside Inn

PB Surf Beachside Inn

PB Surf Beachside Inn
2.5 star property
North Pacific Beach, 31.2 km from Otay Mesa West
8.2 out of 10, Very good, (1005)
"Great stay"
United States
Ernest
The price is 2.394.215 ₫
2.704.146 ₫ total
includes taxes & fees
18 Dec - 19 Dec
PB Surf Beachside Inn
Motel Room, 1 Queen Bed, Main Building, 3rd Floor | Beach/ocean view
The Beach Cottages

The Beach Cottages

The Beach Cottages
2.5 star property
Pacific Beach, 30.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1000)
"Staff was very helpful, place was clean, fun with all the Xmas bars and restaurants."
United States
Gay Marie
The price is 3.289.000 ₫
3.780.508 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
The Beach Cottages
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 17.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1230)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is 3.606.849 ₫
4.181.962 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa West Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Spotless... traveling alone and after staying the night before in the 2nd worse place I have ever stayed - sounds dramatic but I really feared for my life! I could notfeare stayed"
Cynthia 1-night trip
Posted 2 days ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.